Patents by Inventor Raheleh SALARI
Raheleh SALARI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946101Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.Type: GrantFiled: June 21, 2022Date of Patent: April 2, 2024Assignee: Natera, Inc.Inventors: Huseyin Eser Kirkizlar, Raheleh Salari, Styrmir Sigurjonsson, Bernhard Zimmermann, Allison Ryan, Naresh Vankayalapati
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Publication number: 20220403461Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.Type: ApplicationFiled: June 21, 2022Publication date: December 22, 2022Applicant: Natera, Inc.Inventors: Huseyin Eser KIRKIZLAR, Raheleh SALARI, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN, Allison RYAN, Naresh VANKAYALAPATI
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Patent number: 11479812Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.Type: GrantFiled: May 10, 2016Date of Patent: October 25, 2022Assignee: Natera, Inc.Inventors: Huseyin Eser Kirkizlar, Raheleh Salari, Styrmir Sigurjonsson, Bernhard Zimmermann, Allison Ryan, Naresh Vankayalapati
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Patent number: 11447820Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.Type: GrantFiled: May 10, 2016Date of Patent: September 20, 2022Assignee: Natera, Inc.Inventors: Huseyin Eser Kirkizlar, Raheleh Salari, Styrmir Sigurjonsson, Bernhard Zimmermann, Allison Ryan, Naresh Vankayalapati
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Publication number: 20220251654Abstract: The disclosure herein provides methods and compositions for detecting or monitoring immune cell populations in biological samples. The methods and compositions disclosed herein are particularly useful for detecting or monitoring immune cell populations in patients suffering from a disease or undergoing treatment of a disease resulting in depletion of immune cells. In particular, the present disclosure provides method for using multiplex PCR combined with next-generation DNA sequencing to detect DNA containing recombined V(D)J gene segments which can be used to detect immune cells.Type: ApplicationFiled: May 29, 2020Publication date: August 11, 2022Applicant: Natera, Inc.Inventors: Dina M. HAFEZ, Prashanthi NATARAJAN, Raheleh SALARI, Ryan SWENERTON, Bernhard ZIMMERMANN
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Publication number: 20220056509Abstract: The invention provides methods for detecting single nucleotide variants in breast cancer, bladder cancer, or colorectal cancer. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.Type: ApplicationFiled: August 30, 2021Publication date: February 24, 2022Applicant: Natera, Inc.Inventors: Bernhard ZIMMERMANN, Raheleh SALARI, Ryan SWENERTON, Hsin-Ta WU, Himanshu SETHI
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Publication number: 20210257048Abstract: A method for calling a mutation includes determining, for each target base of a plurality of target bases, a respective value for a background error parameter based on training data. The method further includes determining a motif-specific error model including the background error parameter by performing processes that include: identifying a respective motif for each target base of the plurality of target bases, grouping the plurality of target bases into a plurality of groups, each group corresponding to a particular motif, and determining, for each group, a respective motif-specific parameter value for the background error parameter based on the determined values for the background error parameter for the target bases included in each group. The method further includes calling a mutation using the motif-specific error model and sequencing information for a biological sample.Type: ApplicationFiled: June 12, 2019Publication date: August 19, 2021Applicant: Natera, Inc.Inventors: Bernhard ZIMMERMANN, Raheleh SALARI, Ryan SWENERTON, Dina M. HAFEZ
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Publication number: 20190316184Abstract: The invention provides methods for detecting single nucleotide variants in breast cancer, bladder cancer, or colorectal cancer. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.Type: ApplicationFiled: April 12, 2019Publication date: October 17, 2019Applicant: Natera, Inc.Inventors: Bernhard ZIMMERMANN, Raheleh SALARI, Ryan SWENERTON, Hsin-Ta WU, Himanshu SETHI
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Publication number: 20190185913Abstract: The invention provides methods and compositions for detecting a mutation in a target gene in a sample of blood or a fraction thereof, including in certain examples, a fraction that includes circulating tumor DNA. The methods can include a tiling PCR reaction, for example a one-sided multiplex tiling reaction. Virtually any type of mutation can be detected with the methods and compositions. In certain embodiments, gene fusions are detected. Improved PCR methods, especially for performing nested multiplex PCR reactions are provided.Type: ApplicationFiled: June 30, 2017Publication date: June 20, 2019Applicant: Natera, Inc.Inventors: Bernhard ZIMMERMANN, Joshua BABIARZ, Raheleh SALARI, Tudor Pompiliu CONSTANTIN, Onur SAKARYA, Dennis PROSEN, Alexander OLSON, Scott DASHNER, Nikolay SERGEEV, Matthew Micah HILL
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Publication number: 20190106751Abstract: The invention provides methods for detecting single nucleotide variants in lung cancer, especially stage 3a lung adenocarcinoma and lung squamous cell carcinoma. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.Type: ApplicationFiled: April 17, 2017Publication date: April 11, 2019Applicants: Natera, Inc., UCL BUSINESS PLCInventors: Bernhard ZIMMERMANN, Tudor Pompiliu CONSTANTIN, Raheleh SALARI, Huseyin Eser KIRKIZLAR, Robert Charles SWANTON, Mariam JAMAL-HANJANI, Christopher ABBOSH, Gareth WILSON
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Publication number: 20180148777Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.Type: ApplicationFiled: May 10, 2016Publication date: May 31, 2018Applicant: Natera, Inc.Inventors: Huseyin Eser KIRKIZLAR, Raheleh SALARI, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN, Allison RYAN, Naresh VANKAYALAPATI