Abstract: Methods for generating a vascularized tissue engineering construct that involves using the immersed microfluidic spinning to create a network of calcium alginate fibers. These fibers are covered by a layer of the cell-laden hydrogel, another layer of fibers is spun upon the layer of hydrogel, and another layer of hydrogel is deposited over that layer of calcium alginate fibers. DMEM/EDTA/DSC solution is used to dissolve the calcium alginate fibers that would then leave a channel of several hundred microns in diameter inside the cell-laden hydrogel. This microfluidic network can be used to flow the nutrients to the cells and waste products away from the cells inside the hydrogel construct, assisting in the creation of the vascularized tissue construct.

Abstract: A self-powered system for continuous real-time physiological signal monitoring. The system may comprise a charging component configured to generate power from movement of the user, and one or more pressure sensors applied to a user, operatively coupled to the charging component, configured to measure one or more physiological signals of the user and output one or more capacitance values. The charging component may be further configured to power the one or more pressure sensors, and the one or more pressure sensors may comprise MXene. The charging component may comprise an MXene-based triboelectric nanogenerator.

Abstract: The invention relates to a novel biosensor, the metal-insulator transition (MIT) point biosensor, a non-expensive miniaturized device, having a small footprint and high sensitivity, which can measure molecular interactions or the presence of small amounts of molecules without the need for the molecules to be labeled. The sensor comprises a vanadium dioxide (V02) layer located between two metal measuring pads. The introduction of molecules of interest to the sensor surface results in changes in the oxide interface charge density that can be detected by a shift in the metal oxide transition point and differences in the amount of current passing through the oxide. The MIT biosensor is useful for the detection of charged molecules, including macromolecules, such as proteins or nucleic acids as well as other types of particles, such as cells, bacteria, or viruses.

Abstract: Devices and methods for detecting the presence of one or more analytes, such as biomolecules (FIG. 2). An analyte detection device includes at least two conductive structures disposed between three insulating structures and a gap exists in the structures that defines a channel such that at least four electrodes capable of measuring an electrical property are present in the channel. Methods for improving analyte detector performance through low-salt buffer washes also are disclosed.