Abstract: Methods and apparatus to reduce anxiety using mixed reality are disclosed herein. An example method of reducing anxiety in a person during a blood collection process includes providing a mixed reality headset to a person prior to collecting blood from the person. The method includes initiating a mixed reality program on the mixed reality headset. The mixed reality program causes a display device to display a mixed reality environment with one or more virtual objects on glasses of the headset, determines a gaze direction of the eyes of the person, and causes a change in one or more of the virtual objects in the mixed reality environment based on the gaze direction. The method further includes collecting blood from the person while the person is exposed to the mixed reality program.