Abstract: The present disclosure is directed towards systems and methods for controlling three-dimensional bioprinters. In some embodiments, a server system may provide a user interface that can be used by a user may able to provide three-dimensional bioprinter specifications. The server system may then be configured to generate command instructions compatible with a particular bioprinter and then transmit the command instructions to the indicated bioprinter. In some embodiments the disclosed systems and methods may eliminate the need for downloading drivers or bioprinter specific software onto a user computing device. In some embodiments the disclosed systems and methods may be configured for use in restricted internet access settings.