Abstract: A surgical device includes an inner stylet component and an outer stylet component. The inner stylet component includes a first handle and an elongated rod having a proximal end attached to a bottom surface of the first handle and a distal end comprising a needle tip. The outer stylet component includes a second handle and an elongated cannula having a proximal end attached to a bottom surface of the second handle and a distal open end comprising cutting elements formed on an outer surface. The elongated rod is sized to removably fit and slide within the elongated cannula, and the first handle is configured to interlock with the second handle. Rotating the interlocked first and second handles moves forward the elongated cannula and the needle tip and cuts a profile in an insertion site with the cutting elements of the outer cannula.

Abstract: A method for inserting an interspinous spinal implant into an opened gap between first and second spinous processes of adjacent superior and inferior vertebras, respectively includes the following. First forming an opened gap between a first spinous processes of a superior vertebra and a second spinous processes of an adjacent inferior vertebra by first inserting a decompression knife into diseased areas of the adjacent superior and inferior vertebras, then cutting fascia tissue, then separating soft tissue from bone by rocking the decompression knife back and forth, and then inserting a broach cutter into the diseased areas of the adjacent superior and inferior vertebras and cutting interspinous ligament between the adjacent superior and inferior vertebras. Next, determining and selecting an appropriate sized and shaped interspinous spinal implant for the opened gap by inserting a sizing tool into the opened gap, and sizing the opened gap with the sizing tool.

Abstract: A method for inserting an interspinous spinal implant into an opened gap between first and second spinous processes of adjacent superior and inferior vertebras, respectively includes the following. First forming an opened gap between a first spinous processes of a superior vertebra and a second spinous processes of an adjacent inferior vertebra by first inserting a decompression knife into diseased areas of the adjacent superior and inferior vertebras, then cutting fascia tissue, then separating soft tissue from bone by rocking the decompression knife back and forth, and then inserting a broach cutter into the diseased areas of the adjacent superior and inferior vertebras and cutting interspinous ligament between the adjacent superior and inferior vertebras. Next, determining and selecting an appropriate sized and shaped interspinous spinal implant for the opened gap by inserting a sizing tool into the opened gap, and sizing the opened gap with the sizing tool.

Abstract: Pharmaceutical compositions comprising bicalutamide or its pharmaceutically acceptable salts, solvates, single isomers, enantiomers or mixtures thereof, and a hydrophilic excipient, processes for preparing the compositions and finished dosage forms containing them, and methods of use and treatment.

Abstract: Stable and palatable taste masked pharmaceutical compositions of substituted benzhydrylpiperazines and processes for preparing them.