Patents by Inventor Rahul Kohli

Rahul Kohli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyperactive AID/APOBEC and hmC Dominant TET Enzymes
    Publication number: 20240067948
    Abstract: The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC).
    Type: Application
    Filed: April 5, 2023
    Publication date: February 29, 2024
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Kohli, Emily Schutsky, Monica Yun Liu
  • COMPOSITIONS AND METHODS FOR DNA CYTOSINE CARBOXYMETHYLATION
    Publication number: 20230183793
    Abstract: Compositions and methods for carboxymethylation of cytosine containing DNA and applications thereof for direct sequencing of 5mC are disclosed.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 15, 2023
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Kohli, Tong Wang, Emily Schutsky
  • Hyperactive AID/APOBEC and hmC dominant TET enzymes
    Patent number: 11634700
    Abstract: The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC).
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: April 25, 2023
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Kohli, Emily Schutsky, Monica Yun Liu
  • COMPOSITIONS FOR SMALL MOLECULE CONTROL OF PRECISE BASE EDITING OF TARGET NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20230070731
    Abstract: Compositions and methods for small molecule control of precise base editing are disclosed.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 9, 2023
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Kohli, Junwei Shi, Kiara Berrios
  • Hyperactive AID/APOBEC and hmC Dominant TET Enzymes
    Publication number: 20210301278
    Abstract: The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC).
    Type: Application
    Filed: March 19, 2021
    Publication date: September 30, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Kohli, Emily Schutsky, Monica Yun Liu