Abstract: Event-driven management may be implemented for resource pools. Pool management events may be detected at computing resources in a resource pool. Operations based on the pool management events may then be performed at the computing resources. In some embodiments, pool management events may trigger operations to a recycle a computing resource for reuse in a resource pool or perform other resource lifecycle operations.

Abstract: The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or homolog thereof, and a biologically active domain of Interleukin-33 (IL-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application discloses that combination therapies using IL-2 and IL-33 or a therapy using the IL233 fusion protein are effective in preventing or treating diseases and disorders such as autoimmune diseases and disorders, inflammation, etc. Depending on the subject's disease or disorder, the compositions of the invention are useful for preventing certain symptoms, treating the disease, and alleviating at least some of the symptoms.

Abstract: Disclosed are approaches for using overlapping geo-fences to confirm delivery of a shipment. A first client computing device and a second client computing device may be in data communication with a server computing device. The server computing device may receive a delivery notification from the first client computing device. The server computing device may receive a first position of the first client computing device and a second position of the second client computing device. The server computing device may then determine that the second position is within a threshold distance of the first position or vice versa. Finally, the server computing device may generate a delivery confirmation in response to a first determination that the second position is within a threshold distance of the first position and a second determination that the first position is within a threshold distance of the second position.

Abstract: The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or homolog thereof, and a biologically active domain of Interleukin-33 (IL-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application discloses that combination therapies using IL-2 and IL-33 or a therapy using the IL233 fusion protein are effective in preventing or treating diseases and disorders such as autoimmune diseases and disorders, inflammation, etc. Depending on the subject's disease or disorder, the compositions of the invention are useful for preventing certain symptoms, treating the disease, and alleviating at least some of the symptoms.

Abstract: A user interface for a virtual file management system that provides user access to managed content on mobile devices. The system comprises storage domains storing the managed content distributively using file systems, and a data infrastructure that organizes the managed content into a virtual file system. The data infrastructure includes a component that maintains policies defining controls for permissible operations on the managed content, the permissible operations including the file system primitives. A client application including a user interface is hosted on the mobile devices and is coupled to the data infrastructure and the storage domains and includes an enforcement component that retrieves and enforces the policies by applying the controls on the mobile devices.

Abstract: A method for designing a clock tree is disclosed. In one embodiment, a preliminary clock tree design for an integrated circuit (IC) is processed. The clock tree includes a root node, a number of intermediate levels, and a leaf level that is coupled to a number of clocked circuits. Clock gating circuits are placed at the leaf level of the clock tree, and at least some of the intermediate levels. Processing the preliminary clock tree design includes ensuring that an equal number of clock gating circuits are coupled between each leaf level clock gating circuit and the root node. After processing the preliminary clock tree design, clock tree synthesis is performed by executing a clock tree synthesis tool on a computer system to generate a synthesized clock tree design.

Abstract: Disclosed herein is a block copolymer comprising a first segment and a second segment that are covalently bonded to each other and that are chemically different from each other; where the first segment has a first surface free energy and where the second segment has a second surface free energy; and an additive copolymer; where the additive copolymer comprises a surface free energy reducing moiety where the surface free energy reducing moiety has a lower surface free energy than that of the first segment and the second segment; the additive copolymer further comprising one or more moieties having an affinity to the block copolymer; where the surface free energy reducing moiety is chemically different from the first segment and from the second segment; where the additive copolymer is not water miscible; and where the additive copolymer is not covalently bonded with the block copolymer.

Abstract: Disclosed herein is a method comprising disposing a first composition comprising a first block copolymer upon a substrate; where the first block copolymer comprises a first segment and a second segment that are covalently bonded to each other and that are chemically different from each other; where the first segment has a first surface free energy and where the second segment has a second surface free energy; and disposing a second composition comprising an second copolymer upon a free surface of the first block copolymer; where the second copolymer comprises a surface free energy reducing moiety; where the surface free energy reducing moiety has a lower surface free energy than the first surface free energy and the second surface free energy; the second copolymer further comprising one or more moieties having an affinity to the first block copolymer; where the surface free energy reducing moiety is chemically different from the first segment and from the second segment.

Abstract: A system that transforms electronic messages into annotated messages that include contextual information to aid a recipient in utilizing the electronic message, understanding its meaning, and responding to the message. Annotations are additions or modifications to the original message with contextual information that is related to the features and contents of the original message. Message features are extracted and used to search one or more sources of contextual information. Relevant items are retrieved and added to the message, for example as attachments, hyperlinks, or inline notes. Machine learning techniques may be used to generate or refine modules for feature extraction and information selection. Feedback components may be used to track the usage and value of annotations, in order to iteratively improve the annotation system.

Abstract: Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.

Abstract: A solar module (2) comprising: (a) a plurality of interconnected photovoltaic cells (4); (b) a forward protective layer (22); (c) a rearward protective layer (24); and (d) an reinforcement (10); wherein the reinforcement is integrally located within the solar module and extends from a location substantially proximate to the forward protective layer to a location substantially proximate to the rearward protective layer.

Abstract: Disclosed are approaches for using overlapping geo-fences to confirm delivery of a shipment. A first client computing device and a second client computing device may be in data communication with a server computing device. The server computing device may receive a delivery notification from the first client computing device. The server computing device may receive from the first client computing device a first position and a second position from the second client computing device. The server computing device may then determine that the second position is within a predefined distance of the first position or vice versa. Finally, the server computing device may generate a delivery confirmation in response to a first determination that the second position is within a predefined distance of the first position and a second determination that the first position is within a predefined distance of the second position.

Abstract: A system that transforms electronic messages into annotated messages that include contextual information to aid a recipient in utilizing the electronic message, understanding its meaning, and responding to the message. Annotations are additions or modifications to the original message with contextual information that is related to the features and contents of the original message. Message features are extracted and used to search one or more sources of contextual information. Relevant items are retrieved and added to the message, for example as attachments, hyperlinks, or inline notes. Machine learning techniques may be used to generate or refine modules for feature extraction and information selection. Feedback components may be used to track the usage and value of annotations, in order to iteratively improve the annotation system.

Abstract: A system that transforms electronic messages into annotated messages that include contextual information to aid a recipient in utilizing the electronic message, understanding its meaning, and responding to the message. Annotations are additions or modifications to the original message with contextual information that is related to the features and contents of the original message. Message features are extracted and used to search one or more sources of contextual information. Relevant items are retrieved and added to the message, for example as attachments, hyperlinks, or inline notes. Machine learning techniques may be used to generate or refine modules for feature extraction and information selection. Feedback components may be used to track the usage and value of annotations, in order to iteratively improve the annotation system.

Abstract: The invention is a flexible photovoltaic article having excellent environmental barrier and mechanical protection for the photovoltaic system. The article comprises top side protective layers that include a flexible thin film glass under a top side stress relieving layer and on the opposite side of the photovoltaic cell a backside stress relieving layer.

Abstract: The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or homolog thereof, and a biologically active domain of Interleukin-33 (IL-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application discloses that combination therapies using IL-2 and IL-33 or a therapy using the IL233 fusion protein are effective in preventing or treating diseases and disorders such as autoimmune diseases and disorders, inflammation, etc. Depending on the subject's disease or disorder, the compositions of the invention are useful for preventing certain symptoms, treating the disease, and alleviating at least some of the symptoms.

Abstract: A method for designing a clock tree is disclosed. In one embodiment, a preliminary clock tree design for an integrated circuit (IC) is processed. The clock tree includes a root node, a number of intermediate levels, and a leaf level that is coupled to a number of clocked circuits. Clock gating circuits are placed at the leaf level of the clock tree, and at least some of the intermediate levels. Processing the preliminary clock tree design includes ensuring that an equal number of clock gating circuits are coupled between each leaf level clock gating circuit and the root node. After processing the preliminary clock tree design, clock tree synthesis is performed by executing a clock tree synthesis tool on a computer system to generate a synthesized clock tree design.

Abstract: Virtual file management is disclosed. Managed content from multiple separate storage domains is organized into a virtual file system that maintains with respect to each of at least a subset of said separate storage domains information of storage domain specific file system primitives to perform primitive operations with respect to content stored in that storage domain. Policies are determined that apply to the managed content. Each policy indicates primitive operations permitted to be performed with respect to the managed content. Information comprising the virtual file system and the policies is provided to a client application on a mobile device. The client application is configured to provide access to the managed content in the virtual file system in a manner at least in part indicated in the policies, including by allowing the permitted primitive operations to be performed using said storage domain specific file system primitives.

Abstract: Charge to voltage conversion integrator circuitry for data acquisition front-end and other applications to provide a single-ended up a voltage using an input bias capacitance and a switching circuit to selectively place an input transistor in a negative feedback configuration in a first mode to charge the input bias capacitance to a calibration voltage for compensating integrator amplifier bias circuitry, with the switching circuit connecting an input node and the input bias capacitance in a second mode to integrate the input current signal across a feedback capacitance to provide a single-ended output voltage with the input bias capacitance maintaining a zero voltage at the input node.