Abstract: Systems and methods for using token application programming interfaces are disclosed. According to an embodiment, a method for using token programming interfaces may include: (1) receiving, at an eligibility application programming interface (API), a token or a Digital Primary Account Number (DPAN) for a financial instrument from a merchant or a payment facilitator backend; (2) calling, by the eligibility API, a Funding Primary Account Number (FPAN) lookup API with the token or DPAN; (3) receiving, by the eligibility API, the FPAN for the token or DPAN from the FPAN lookup API; (4) generating, by the eligibility API, an issuer reference identifier for the FPAN; (5) storing, by the eligibility API, a mapping between the FPAN and the issuer reference identifier; and (6) communicating, by the eligibility API and via the eligibility API, the issuer reference identifier to the merchant or the payment facilitator backend.

Abstract: Systems and methods for using token application programming interfaces are disclosed. According to an embodiment, a method for using token programming interfaces may include: (1) receiving, at an eligibility application programming interface (API), a token or a Digital Primary Account Number (DPAN) for a financial instrument from a merchant or a payment facilitator backend; (2) calling, by the eligibility API, a Funding Primary Account Number (FPAN) lookup API with the token or DPAN; (3) receiving, by the eligibility API, the FPAN for the token or DPAN from the FPAN lookup API; (4) generating, by the eligibility API, an issuer reference identifier for the FPAN; (5) storing, by the eligibility API, a mapping between the FPAN and the issuer reference identifier; and (6) communicating, by the eligibility API and via the eligibility API, the issuer reference identifier to the merchant or the payment facilitator backend.

Abstract: Systems and methods for using token application programming interfaces are disclosed. According to an embodiment, a method for using token programming interfaces may include: (1) receiving, at an eligibility application programming interface (API), a token or a Digital Primary Account Number (DPAN) for a financial instrument from a merchant or a payment facilitator backend; (2) calling, by the eligibility API, a Funding Primary Account Number (FPAN) lookup API with the token or DPAN; (3) receiving, by the eligibility API, the FPAN for the token or DPAN from the FPAN lookup API; (4) generating, by the eligibility API, an issuer reference identifier for the FPAN; (5) storing, by the eligibility API, a mapping between the FPAN and the issuer reference identifier; and (6) communicating, by the eligibility API and via the eligibility API, the issuer reference identifier to the merchant or the payment facilitator backend.

Abstract: This disclosure relates generally to method for signal pre-processing based on a plurality of data driven models and a data dependent model transformation. The method includes (a) receiving, a raw signal as an input; (b) learning, a set of representational basis from the received raw signal, wherein the set of representational basis comprises a plurality of orthonormal vectors; (c) selecting, at least one orthonormal vector from the plurality of orthonormal vectors, (d) determining, a structure of the plurality of dictionary atoms, wherein structure of the plurality of dictionary atoms corresponds to a graph structure represented as a Laplacian matrix (L); (e) integrating, the graph structure as a structure of the set of representational basis to obtain a reconfigured data model; and (f) reconstructing, using the reconfigured data model to obtain a denoised signal, wherein at least one of constraints on a optimization problem corresponds to desired spectral and topological structure.

Abstract: The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Abstract: Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.

Abstract: This disclosure relates generally to method for signal pre-processing based on a plurality of data driven models and a data dependent model transformation. The method includes (a) receiving, a raw signal as an input; (b) learning, a set of representational basis from the received raw signal, wherein the set of representational basis comprises a plurality of orthonormal vectors; (c) selecting, at least one orthonormal vector from the plurality of orthonormal vectors, (d) determining, a structure of the plurality of dictionary atoms, wherein structure of the plurality of dictionary atoms corresponds to a graph structure represented as a Laplacian matrix (L); (e) integrating, the graph structure as a structure of the set of representational basis to obtain a reconfigured data model; and (f) reconstructing, using the reconfigured data model to obtain a denoised signal, wherein at least one of constraints on a optimization problem corresponds to desired spectral and topological structure.

Abstract: The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Abstract: The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Abstract: Disclosed is a method and system for reducing data size of raw data. The system may process the raw data for calculating Renyi entropies, Wigner Ville Distributions (WVD's), Wigner Ville Spectrum (WVS) and Renyi divergence. The system may identify a first set of windows followed by a second set of windows while processing the raw data. Further, the system may calculate Eigen values for a Time-Frequency matrix of WVS of the second set of windows. The system may filter the second set of windows based on the Eigen values for preparing a third set of windows. The system prepares clusters of the Eigen values. The system may compute centroids of the clusters of the Eigen values. The system classifies each window of the third set of windows into one of the clusters indicating a relevant category of event identified from the raw data.

Abstract: Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.

Abstract: The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Abstract: Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent by assaying biological samples for the level or ratio of isoforms of CD47 in the sample.

Abstract: This disclosure relates to systems and methods for adaptively compressing data based on compression parameters. In one embodiment, a method for compressing a dataset is disclosed, including filtering a dataset based on occurrence of an event, and determining a quality of information index indicating a measure of quality of the dataset based on a quality of information estimation function. The method may include comparing the quality of information index with a list of indices stored in a lookup table to identify a target quality of information index and corresponding compression parameters, wherein the target quality of information index is indicative of a reference measure of quality of the dataset applicable for deriving statistical inferences based on analysis of the dataset. Also, the method may include inputting the compression parameters in a compression algorithm for compressing the dataset to achieve the target quality of information index for the analysis.

Abstract: Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent by assaying biological samples for the level or ratio of isoforms of CD47 in the sample.

Abstract: Disclosed is a method and system for reducing data size of raw data. The system may process the raw data for calculating Renyi entropies, Wigner Ville Distributions (WVD's), Wigner Ville Spectrum (WVS) and Renyi divergence. The system may identify a first set of windows followed by a second set of windows while processing the raw data. Further, the system may calculate Eigen values for a Time-Frequency matrix of WVS of the second set of windows. The system may filter the second set of windows based on the Eigen values for preparing a third set of windows. The system prepares clusters of the Eigen values. The system may compute centroids of the clusters of the Eigen values. The system classifies each window of the third set of windows into one of the clusters indicating a relevant category of event identified from the raw data.

Abstract: A method and system for validating presence of a communication device in a confined area using a wireless local area network (WLAN) includes sending a first handshake message including a generated first key over a second network connection different from the WLAN connection by a device. A next step includes generating a second key to be returned to the device in a second handshake message over the same connection. A next step includes sending a WLAN probe request that has been modified to include the second key via the WLAN. A next step includes validating whether the device is present within the confined area using a second communication network; whereafter allowing communication access over the second network using both the first and second keys if the device is validated as being present within the confined area, and taking appropriate action if the device is not validated as being present within the confined area.

Abstract: This disclosure relates to systems and methods for adaptively compressing data based on compression parameters. In one embodiment, a method for compressing a dataset is disclosed, including filtering a dataset based on occurrence of an event, and determining a quality of information index indicating a measure of quality of the dataset based on a quality of information estimation function. The method may include comparing the quality of information index with a list of indices stored in a lookup table to identify a target quality of information index and corresponding compression parameters, wherein the target quality of information index is indicative of a reference measure of quality of the dataset applicable for deriving statistical inferences based on analysis of the dataset. Also, the method may include inputting the compression parameters in a compression algorithm for compressing the dataset to achieve the target quality of information index for the analysis.

Abstract: The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Abstract: A method and system for validating presence of a communication device in a confined area using a wireless local area network (WLAN) includes sending a first handshake message including a generated first key over a second network connection different from the WLAN connection by a device. A next step includes generating a second key to be returned to the device in a second handshake message over the same connection. A next step includes sending a WLAN probe request that has been modified to include the second key via the WLAN. A next step includes validating whether the device is present within the confined area using a second communication network; whereafter allowing communication access over the second network using both the first and second keys if the device is validated as being present within the confined area, and taking appropriate action if the device is not validated as being present within the confined area.