Patents by Inventor Raik-Hiio Mikelsaar

Raik-Hiio Mikelsaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • inducia DSM 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against
    Patent number: 10272122
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhea (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 30, 2019
    Assignee: BIOCC OÜ
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • LACTOBACILLUS PLANTARUM INDUCIA DSM 21379 AS ENHANCER OF CELLULAR IMMUNITY, HYPOCHOLESTEROLEMIC AND ANTI-OXIDATIVE AGENT AND ANTIMICROBIAL AGENT AGAINST CLOSTRIDIUM DIFFICILE
    Publication number: 20160296570
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 13, 2016
    Applicant: TERVISLIKU PllMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, lmbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • LACTOBACILLUS PLANTARUM INDUCIA DSM 21379 AS ENHANCER OF CELLULAR IMMUNITY, HYPOCHOLESTEROLEMIC AND ANTI-OXIDATIVE AGENT AND ANTIMICROBIAL AGENT AGAINST CLOSTRIDIUM DIFFICILE
    Publication number: 20140335066
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 3, 2014
    Publication date: November 13, 2014
    Applicant: TERVISLIKU PIIMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Kõljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • DNA-binding proteins of the zinc-finger class
    Patent number: 6205404
    Abstract: The invention is directed to the design of DNA-binding proteins (DBP's) with capabilities of binding to any predetermined target double-stranded DNA sequence. Disclosed are the rules for design of the proteins; an algorithm for screening for the optimal DBP's; a computer system employing the rules and the algorithm; general formulae encompassing the proteins; and methods of use of the proteins.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: March 20, 2001
    Inventors: George S. Michaels, Raik-Hiio Mikelsaar, Richard J. Feldmann