Abstract: A knot pusher device for deploying a plurality of pretied knots to a surgical site is provided. In one embodiment, the knot pusher device comprises a shaft, an inner tubular member, and an inner rod, each having a proximal end and a distal end. The inner tubular member is provided within the shaft and is radially translatable with respect to the shaft. The inner rod is provided within the inner tubular member and is slidably coupled to the inner tubular member and is axially translatable with respect thereto.

Abstract: A vascular closure delivery system is provided comprising a needle and suture delivery unit and a suture knot system. The delivery unit may comprise a tube, a leg, a tensioning device, a pusher, a needle, and an actuator, the tube being configured to house the needle. In an open position, the tensioning device exerts tension on the leg, and the pusher and suturing apparatus are in a delivery configuration for delivering the needle to the internal tissue wall. Further, actuation of the actuator moves the pusher towards an expulsion end of the tube such that the pusher engages the needle and expels the needle from the tube. The suture knot system comprises a shaft, an inner tubular member, and an inner rod. The inner tubular member is radially translatable with respect to the shaft. The inner rod is slidably coupled to and is axially translatable within the inner tubular member.

Abstract: The present invention is directed to methods and apparatus for cutting filaments percutaneously. The methods and systems may be used in conjunction with sealing a puncture percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The present invention provides for safe filament cutting below the skin and may reduce the risk of cutting the filament distal of any knots.

Abstract: The invention provides methods and apparatus, including computer program products, for processing medical data of a database, the medical data relating to diseases, and symptoms related to the diseases, said method including, Requesting an individual user to input data descriptive of a symptom; searching the database for data descriptive of diseases related to the inputted data descriptive of the symptom; generating a report listing diseases which are related to the inputted data descriptive of the symptom; associating a frequency indication to the each of the listed diseases, the frequency indication being representative of the frequency of reported associations of the respective listed disease; outputting the report with the frequency indication associated with each of the listed diseases.

Abstract: A vascular closure delivery system for closing a tissue wall opening is provided. In one embodiment, the vascular closure delivery system comprises a suturing apparatus and suture delivery unit and a suture knot system. The suturing apparatus and suture delivery unit comprises at least one tube, at least one leg, a tensioning device, a pusher, a suturing apparatus, and an actuator. The at least one tube is configured to house the pusher and the suturing apparatus and has an expulsion end. The at least one leg has a first end and a second and is coupled to the at least one tube proximate the first end of the leg. The tensioning device is coupled to the at least one leg proximate the second end of the leg. The pusher has a suturing apparatus engaging end and is slidably disposed within the tube. The suturing apparatus has a sharp end and an opposite end and is slidably disposed within the tube. A suture is associated with the suturing apparatus. The actuator is operatively associated with the pusher.

Abstract: A knot pusher device for deploying a plurality of pretied knots to a surgical site is provided. In one embodiment, the knot pusher device comprises a shaft, an inner tubular member, and an inner rod, each having a proximal end and a distal end. The inner tubular member is provided within the shaft and is radially translatable with respect to the shaft. The inner rod is provided within the inner tubular member and is slidably coupled to the inner tubular member and is axially translatable with respect thereto.

Abstract: The present invention is directed to methods and apparatus for cutting filaments percutaneously. The methods and systems may be used in conjunction with sealing a puncture percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The present invention provides for safe filament cutting below the skin and may reduce the risk of cutting the filament distal of any knots.

Abstract: For guiding at least two sutures through a wall of a membrane, of a balloon or of a surface, in particular of an artery of an individual, in the vicinity of the edge region of an opening provided therein and for drawing back out of the abovementioned opening the suture ends guided through the relevant wall, the invention provides a shaft-like suture-guide device which, in its longitudinal direction, contains a rear suture-feed part (3), a front suture-accommodating part (4) and a central suture-release/suture-clamping part located therebetween; the central suture-release/ suture-clamping part (5) can be expanded in one axial direction such that that membrane, balloon or surface or vessel wall of an artery of an individual which is located in the region of the relevant central suture-release/suture-clamping part (5) is thus subjected to tensioning, on account of which those edge regions of the abovementioned wall which are provided transversely to said tensioning direction draw together toward one another.