Patents by Inventor Raimo E. Virtanen

Raimo E. Virtanen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4(5) substituted imidazoles and their preparation and use
    Patent number: 5498623
    Abstract: The invention provides compounds of the formula ##STR1## wherein Y is --CH.sub.2 -- or --CO--;R.sub.1 is F, Cl or OH; R.sub.2 is H, F or Cl; and R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3, excluding 4-(5-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and 4-(4-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; and their non-toxic acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are pharmaceutical compositions comprising at least one of the compounds or its salt. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are highly selective and long acting antagonists at .alpha..sub.2 -adrenoceptors. Their peroral bioavailability is good. The compounds are especially useful in the treatment of cognitive disorders.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: March 12, 1996
    Assignee: Orion-yhtyma Oy
    Inventors: Arto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen, Maire M. Eloranta, Jarmo S. Salonen, Hannu T. Sipila, Antti S. Haapalinna
  • Imidazoles for the treatment of age-related cognitive disorders and alzheimer
    Patent number: 5434177
    Abstract: This invention relates to the use of a compound of formula ##STR1## wherein X is --CH.sub.2 -- or ##STR2## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be substituted of unsubstituted; R.sub.2 is H, C.sub.1-4 -alkyl, C.sub.1-4 -alkenyl, OH, or C.sub.1-3 -alkoxy; R.sub.3 is H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal; R.sub.4 H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal, and Hal is halogen, provided that when R.sub.2 is OH or C.sub.1-3 -alkoxy then X cannot be CO or a non-toxic pharmaceutically acceptable salt thereof for the use in the treatment of age related memory impairment or cognitive disorders, particularly Alzheimer's Disease.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: July 18, 1995
    Assignee: Orion-Yhtyma Oy
    Inventors: Paavo J. Riekkinen, Paavo Riekkinen, Jr., Jouni S. I. Sirvio, Riitta A. Miettinen, Antti Valjakka, Mauno M. Airaksinen, Sakari A. Nieminen, Ewen MacDonald, Risto A. S. Lammintausta, Raimo E. Virtanen
  • Substituted imidazole derivatives and their preparation and use
    Patent number: 5292887
    Abstract: Compounds of the formula: ##STR1## wherein X is --CH.sub.2 -- or ##STR2## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be substituted or unsubstitutedR.sub.2 is H, C.sub.1-4 -alkyl, OH or C.sub.1-3 -alkoxyR.sub.3 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or HalR.sub.4 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal and Hal is halogen and non-toxic acid addition salts and mixtures thereof are highly selective antagonists at postsynaptic .alpha..sub.2 -adrenoceptors, and are especially useful in the treatment of diabetes.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: March 8, 1994
    Assignee: Farmos-yhtyma Oy
    Inventors: Arto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen
  • Optical isomer of an imidazole derivative medetomidine as an alpha-2-receptor agonist
    Patent number: 4910214
    Abstract: The separated d and l enantiomers of medetomidine and their salts are selective and potent .alpha..sub.2 -receptor agonists.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: March 20, 1990
    Assignee: Farmos Yhtyma Oy
    Inventors: Arto J. Karjalainen, Raimo E. Virtanen, Eino J. Savolainen
  • 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydrobenzofuran-2-ylimidazoles, useful to block .alpha..sub.2 -adrenergic receptors
    Patent number: 4689339
    Abstract: A process for the preparation of a substituted imidazole of the formula ##STR1## wherein X is --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --O-- R.sub.1 is H, lower alkyl or lower alkenyl, OCH.sub.3 or OCH.sub.2 CH.sub.3, R.sub.2 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or OH, R.sub.3 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal, R.sub.4 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal, and Hal is halogen and their non-toxic acid addition salts exhibit valuable pharmacological activity and are useful especially as selective .alpha..sub.2 -receptor antagonists.
    Type: Grant
    Filed: November 21, 1985
    Date of Patent: August 25, 1987
    Assignee: Farmos Yhtyma oy
    Inventors: Arto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen, Kauko O. A. Kurkela
  • Method of bringing about sedation and/or analgesia in a mammal
    Patent number: 4670455
    Abstract: 4-[(.alpha.-Methyl)-2,3-dimethyl-benzyl]imidazole is useful as a veterinary sedative-analgetic agent, especially in small mammals.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: June 2, 1987
    Assignee: Farmos-Yhtyma Oy
    Inventors: Raimo E. Virtanen, Arto J. Karjalainen, Kauko O. A. Kurkela, Antti T. Vaha-Vahe, Outi M. Vainio-Kivinen