Patents by Inventor Raimond Heukers

Raimond Heukers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inverse Agonistic Anti-US28 Antibodies
    Publication number: 20240309071
    Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.
    Type: Application
    Filed: June 7, 2024
    Publication date: September 19, 2024
    Inventors: Martine Joyce Smit, Raimond Heukers, Timo Werner Marcella De Groof, Tian Shu Fan, Raymond Henry De Wit
  • Inverse agonistic anti-US28 antibodies
    Patent number: 12037382
    Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: July 16, 2024
    Assignee: Stichting VU
    Inventors: Martine Joyce Smit, Raimond Heukers, Timo Werner Marcella De Groof, Tian Shu Fan, Raymond Henry De Wit
  • Identification and Elimination of HCMV-Infected Cells
    Publication number: 20220324947
    Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.
    Type: Application
    Filed: August 5, 2020
    Publication date: October 13, 2022
    Inventors: Martine Joyce Smit, Timo Werner Marcella De Groof, Raimond Heukers, John Sinclair, Elizabeth Elder
  • Inverse Agonistic Anti-US28 Antibodies
    Publication number: 20210032316
    Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.
    Type: Application
    Filed: February 5, 2019
    Publication date: February 4, 2021
    Inventors: Martine Joyce Smit, Raimond Heukers, Timo Werner Marcella De Groof, Tian Shu Fan, Raymond Henry De Wit