Patents by Inventor Raimundo Ubieta Gómez
Raimundo Ubieta Gómez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230190866Abstract: Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as “cytokine storm”. The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition.Type: ApplicationFiled: April 12, 2021Publication date: June 22, 2023Inventors: María del Carmen DOMÍNGUEZ HORTA, Rafael VENEGAS RODRIGUEZ, Gillian MARTÍNEZ DONATO, Gerardo Enrique GUILLEN NIETO, Mabel HERNÁNDEZ CEDEÑO, Lilia María ORTEGA GONZÁLEZ, Hugo NODARSE CUNI, Cruz Matilde LOPEZ ABAD, Hilda Elisa GARAY PEREZ, Raimundo UBIETA GÓMEZ
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Publication number: 20230046501Abstract: Polypeptides comprising functional mutants of an isoform of the human vascular endothelial growth factor A (VEGF-A) folded in a non-natural re-arrangement, where the second and fourth cysteine of the mutant's polypeptide chain is only forming intramolecular bridges, while the seventh and eight are only part of intermolecular bonds. The invention further comprises antigenic preparations containing at least one of these polypeptides, and the pharmaceutical compositions comprising such antigenic preparations and vaccine adjuvants. The antigenic preparations according to the invention are used in the manufacturing of a drug, for the treatment of diseases related to the increment of angiogenesis, inflammation, and immunosuppression, as well as for the restoration of the immune system.Type: ApplicationFiled: December 21, 2020Publication date: February 16, 2023Inventors: Monica BEQUET ROMERO, Yanelys MORERA DIAZ, Marta AYALA ÁVILA, Jorge Victor GAVILONDO COWLEY, Javier SÁNCHEZ RAMÍREZ, Francisco HERNÁNDEZ BERNAL, Sonia GONZALEZ BLANCO, Luis Ariel ESPINOSA RODRÍGUEZ, Vladimir Armando BESADA PÉREZ, Mariela PÉREZ DE LA IGLESIA, Lian TRIMIÑO LORENZO, Miladys LIMONTA FERNÁNDEZ, Raimundo UBIETA GÓMEZ
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Patent number: 11564975Abstract: The present invention is related to the use of the growth hormone releasing peptide-6 (GHRP-6) for the manufacture of a late cardioprotective and cardiac restoration medicament. Said late cardioprotective and cardiac restoration medicament comprises GHRP-6 and a pharmaceutically acceptable excipient or vehicle. It also provides a method for the treatment of a disease that involves a low cardiac output, wherein a therapeutically effective amount of a late cardioprotective and cardiac restoration medicament comprising GHRP-6 is administered to a subject in need. Said medicament allows treating in a late manner, even days later, the myocardium that suffered episodes of stunning, hibernation, ischemia and its consequences thereof.Type: GrantFiled: August 19, 2019Date of Patent: January 31, 2023Assignee: Centro de Ingeniería Genética y BiotecnologíaInventors: Jorge Amador Berlanga Acosta, Gerardo Enrique Guillén Nieto, Diana Garcia Del Barco Herrera, Francisco Hernández Bernal, Sonia Gonzalez Blanco, Raimundo Ubieta Gómez
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Publication number: 20220168391Abstract: The present invention reveals the use of epidermal growth factor (EGF) for the manufacture of an injectable medicament for the treatment of a diabetic foot ulcer (DFU), in a patient without criteria of amputation of the affected limb at the time of the clinical evaluation, wherein the medicament comprising EGF is administered by intralesional infiltration in said ulcer once a week. Moreover, it provides a pharmaceutical composition comprising EGF, for the treatment of a DFU in a patient, where the composition is administered once a week. The invention comprises a method for the treatment of a DFU in a patient, without criteria of amputation of the affected limb at the time of the clinical evaluation, comprising administering EGF to the patient, by intralesional infiltration in the ulcer base once a week.Type: ApplicationFiled: March 16, 2020Publication date: June 2, 2022Inventors: Amaurys DEL RIO MARTIN, Hose Esteban SAURI CHAVEZ, Raimundo UBIETA GÓMEZ, Sonia GONZALEZ BLANCO, Jorge Amador BERLANGA ACOSTA, Verena Lucila MUZIO GONZÁLEZ, Eulogio PIMENTEL VÁZQUEZ
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Publication number: 20210252109Abstract: The present invention is related to the use of the growth hormone releasing peptide-6 (GHRP-6) for the manufacture of a late cardioprotective and cardiac restoration medicament. Said late cardioprotective and cardiac restoration medicament comprises GHRP-6 and a pharmaceutically acceptable excipient or vehicle. It also provides a method for the treatment of a disease that involves a low cardiac output, wherein a therapeutically effective amount of a late cardioprotective and cardiac restoration medicament comprising GHRP-6 is administered to a subject in need. Said medicament allows treating in a late manner, even days later, the myocardium that suffered episodes of stunning, hibernation, ischemia and its consequences thereof.Type: ApplicationFiled: August 19, 2019Publication date: August 19, 2021Inventors: Jorge Amador BERLANGA ACOSTA, Gerardo Enrique GUILLÉN NIETO, Diana GARCIA DEL BARCO HERRERA, Francisco HERNÁNDEZ BERNAL, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
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Patent number: 11013235Abstract: The following invention discloses a method for the control of plant diseases wherein a composition comprising a compound having the structure represented by one of the formulas from I to V, is applied to the plants. It also discloses the use of said compounds, or their salts for the stimulation of the natural defense and the induction of resistance against plant diseases. Moreover, it comprises the use of said compounds of structure represented by one of the formulas from I to V for the preventive or curative treatment of said diseases. A composition for agriculture, comprising a compound having the structure represented by one of the formulas from I to V, is also part of the invention.Type: GrantFiled: January 24, 2020Date of Patent: May 25, 2021Assignee: Centro de Ingeniería Genética y BiotecnologíaInventors: Osmany Guirola Cruz, Orlando Borrás Hidalgo, Luis Javier González López, Raimundo Ubieta Gómez, Eulogio Pimentel Vázquez, Merardo Pujol Ferrer
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Patent number: 10993438Abstract: The following invention discloses a method for the control of plant diseases wherein a composition comprising a compound having the structure represented by one of the formulas from I to V, is applied to the plants. It also discloses the use of said compounds, or their salts for the stimulation of the natural defense and the induction of resistance against plant diseases. Moreover, it comprises the use of said compounds of structure represented by one of the formulas from I to V for the preventive or curative treatment of said diseases. A composition for agriculture, comprising a compound having the structure represented by one of the formulas from I to V, is also part of the invention.Type: GrantFiled: August 1, 2016Date of Patent: May 4, 2021Assignee: Centro de Ingeniería Genética y BiotecnologíaInventors: Osmany Guirola Cruz, Orlando Borrás Hidalgo, Luis Javier González López, Raimundo Ubieta Gómez, Eulogio Pimentel Vázquez, Merardo Pujol Ferrer
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Publication number: 20200288720Abstract: The following invention discloses a method for the control of plant diseases wherein a composition comprising a compound having the structure represented by one of the formulas from I to V, is applied to the plants. It also discloses the use of said compounds, or their salts for the stimulation of the natural defense and the induction of resistance against plant diseases. Moreover, it comprises the use of said compounds of structure represented by one of the formulas from I to V for the preventive or curative treatment of said diseases. A composition for agriculture, comprising a compound having the structure represented by one of the formulas from I to V, is also part of the invention.Type: ApplicationFiled: January 24, 2020Publication date: September 17, 2020Inventors: Osmany GUIROLA CRUZ, Orlando BORRÁS HIDALGO, Luis Javier GONZÁLEZ LÓPEZ, Raimundo UBIETA GÓMEZ, Eulogio PIMENTEL VÁZQUEZ, Merardo PUJOL FERRER
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Patent number: 10434137Abstract: The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the the proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, including peptides and/or interfering RNA and/or lipidic compounds, the agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection.Type: GrantFiled: November 17, 2015Date of Patent: October 8, 2019Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Celia Berta Fernandez Ortega, Anna Caridys Ramírez Suarez, Dionne Casillas Casanova, Taimi Emelia Paneque Guerrero, Raimundo Ubieta Gomez, Marta Dubed Echevarria, Leonor Margarita Navea Leyva, Lila Rosa Castellanos Serra, Carlos Antonio Duarte Cano, Viviana Falcon Cama, Osvaldo Reyes Acosta
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Publication number: 20180256112Abstract: The present invention is related to a stereotaxic frame for extremities that ensures that the extremity position is fixed and reproducible; keeping the same geometric conditions of the measurement or treatment devices regards the extremity, or part thereof, during the study or therapy. The frame comprises a positioning and fixing holder for the extremity and a measuring or treatment system, that includes a geometric locus where the measurement or treatment device is allocated, ensuring that the relative position of said device regards the region of the extremity under examination or treatment is reproducible.Type: ApplicationFiled: September 22, 2016Publication date: September 13, 2018Inventors: Carlos Alberto CABAL MIRABAL, Evelio Rafael GONZÁLEZ DALMAU, Leonardo ORAMAS DIAZ, Luis Saturnino HERRERA MARTINEZ, Jorge Amador BERLANGA ACOSTA, José Ignacio FERNÁNDEZ MONTEQUÍN, Gerardo Enrique GUILLÉN NIETO, Luis Manuel FLORES DÍAZ, Orestes Lucio CABAÑAS RODRÍGUEZ, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
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Publication number: 20180213786Abstract: The following invention discloses a method for the control of plant diseases wherein a composition comprising a compound having the structure represented by one of the formulas from I to V, is applied to the plants. It also discloses the use of said compounds, or their salts for the stimulation of the natural defense and the induction of resistance against plant diseases. Moreover, it comprises the use of said compounds of structure represented by one of the formulas from I to V for the preventive or curative treatment of said diseases. A composition for agriculture, comprising a compound having the structure represented by one of the formulas from I to V, is also part of the invention.Type: ApplicationFiled: August 1, 2016Publication date: August 2, 2018Inventors: Osmany GUIROLA CRUZ, Orlando BORRÁS HIDALGO, Luis Javier GONZÁLEZ LÓPEZ, Raimundo UBIETA GÓMEZ, Eulogio PIMENTEL VÁZQUEZ, Merardo PUJOL FERRER
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Publication number: 20160129073Abstract: The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-la The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g.Type: ApplicationFiled: November 17, 2015Publication date: May 12, 2016Inventors: Celia Berta Fernandez Ortega, Anna Caridys Ramírez Suarez, Dionne Casillas Casanova, Taimi Emelia Paneque Guerrero, Raimundo Ubieta Gomez, Marta Dubed Echevarria, Leonor Margarita Navea Leyva, Lila Rosa Castellanos Serra, Carlos Antonio Duarte Cano, Viviana Falcon Cama, Osvaldo Reyes Acosta
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Publication number: 20160108404Abstract: The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g.Type: ApplicationFiled: November 17, 2015Publication date: April 21, 2016Inventors: Celia Berta Fernandez Ortega, Anna Caridys Ramírez Suarez, Dionne Casillas Casanova, Taimi Emelia Paneque Guerrero, Raimundo Ubieta Gomez, Marta Dubed Echevarria, Leonor Margarita Navea Leyva, Lila Rosa Castellanos Serra, Carlos Antonio Duarte Cano, Viviana Falcon Cama, Osvaldo Reyes Acosta
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Publication number: 20160106810Abstract: The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g.Type: ApplicationFiled: November 17, 2015Publication date: April 21, 2016Inventors: Celia Berta Fernandez Ortega, Anna Caridys Ramírez Suarez, Dionne Casillas Casanova, Taimi Emelia Paneque Guerrero, Raimundo Ubieta Gomez, Marta Dubed Echevarria, Leonor Margarita Navea Leyva, Lila Rosa Castellanos Serra, Carlos Antonio Duarte Cano, Viviana Falcon Cama, Osvaldo Reyes Acosta
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Patent number: 9205128Abstract: The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g.Type: GrantFiled: April 1, 2011Date of Patent: December 8, 2015Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIAInventors: Celia Berta Fernandez Ortega, Anna Caridys Ramírez Suárez, Dionne Casillas Casanova, Taimi Emelia Paneque Guerrero, Raimundo Ubieta Gómez, Marta Dubed Echevarria, Leonor Margarita Navea Leyva, Lila Rosa Castellanos Serra, Carlos Antonio Duarte Cano, Viviana Falcón Cama, Osvaldo Reyes Acosta
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Patent number: 9205130Abstract: The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.Type: GrantFiled: February 10, 2011Date of Patent: December 8, 2015Assignees: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA, BIOREC S.A.Inventors: Raimundo Ubieta Gómez, Ana Aguilera Barreto, Eduardo Martínez Díaz, Rolando Paez Meireles, Antonio Sereno Guerra
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Patent number: 9034826Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.Type: GrantFiled: December 26, 2013Date of Patent: May 19, 2015Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
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Patent number: 8748411Abstract: Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.Type: GrantFiled: May 5, 2006Date of Patent: June 10, 2014Assignee: Centro de Ingenieria Genetica y BiotechnologiaInventors: Rolando Eduardo Rodriguez Fernandez, Roberto Vera Alvarez, Ania De La Nuez Veulens, Yuliet Mazola Reyes, Silvio Ernesto Perea Rodriguez, Boris Ernesto Acevedo Castro, Alexis Musacchio Lasa, Raimundo Ubieta Gómez
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Publication number: 20140105990Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.Type: ApplicationFiled: December 26, 2013Publication date: April 17, 2014Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
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Patent number: 8642552Abstract: The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.Type: GrantFiled: October 1, 2007Date of Patent: February 4, 2014Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez