Patents by Inventor Rainer Clauss

Rainer Clauss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of optically enriched (R)- or (S)-albuterol
    Patent number: 6365756
    Abstract: A process for the production of optically enriched (R)- or (S)-albuterol or (R)- or (S)-albuterol salts by the resolution of a novel ketal derivative 2-(N-t-butylamino)-1-(+2,2-dimethyl-1,2-benzodioxin-6-yl) ethanol, with a chiral tartaric acid derivative.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: April 2, 2002
    Assignee: Fine Chemical Corporation Limited
    Inventors: Anne Stevens, Roger Hunter, Luigi Nassimbeni, Mino Caira, Janet Scott, Rainer Clauss, Joanne Gibson, Tarron Grimmbacher
  • Process for the optical resolution of 3-(p-chlorophenyl)-glutaramide
    Patent number: 6051734
    Abstract: A process for the optical resolution of racemic 3-(p-chlorophenyl)glutaramide (GAM) into its R isomer R--COOH and its S isomer S--COOH, which process includes the steps of either:(1) reacting racemic 3-(p-chlorophenyl)-glutaramide dissolved in a suitable solvent with S-(-)-.alpha.-methylbenzylamine of the formula H.sub.2 N--S'(2) precipitating out of the solution of step (1) R--CO.sub.2.sup.-.H.sub.3.sup.+ N--S';(3) dissolving the precipitate of step (2) in water, with the addition of a suitable acid; and(4) precipitating out of the solution of step (3) R--COOH; or(5) reacting racemic -3-(p-chlorophenyl)-glutaramide dissolved in a suitable solvent with R-(+)-.alpha.-methylbenzylamine of the formula H.sub.2 N--R';(6) precipitating out of the solution of step (5) S--CO.sub.2.sup.-.H.sub.3.sup.+ N--R';(7) dissolving the precipitate of step (6) in water, with the addition of a suitable acid, and(8) precipitating out of the solution of step (7) S--COOH.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: April 18, 2000
    Assignee: Farmarc Nederland B.V.
    Inventors: Alexander Franciscus Wildervanck, Mino Rodolfo Caira, Janet Lesley Scott, Liugi Renzo Nassimbeni, Rainer Clauss, Barratt Robert Dixon Easter