Abstract: A method of re-locating an object in a sample is provided for a previously-scanned slide having determined objects each with corresponding stored coordinates and a stored image, the objects being mapped relative to each other. The slide is positioned on a microscope stage, stored images of the objects are visually displayed, and a target object is selected. The slide is moved to an estimated coordinate position, corresponding to the coordinates of the target object, and a field-of-view image of the sample is captured for comparison to the stored image of the target. If the target is in the image, an offset between actual coordinates of the located target and the stored coordinates of the corresponding object is determined. The slide is then moved, via the stage, from the estimated coordinate position, according to the offset, to center the target in the image. Associated systems and methods are also provided.

Abstract: A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y-directions.

Abstract: A slide viewer capable of simultaneous display of more than one representation of an area of interest of a slide is provided. The slide viewer includes a database containing at least two data files representing different representations for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same representation. The representations are views of different illumination and/or of different contrast. Associated with the database are a processor and a display. The processor retrieves data files representing different representations of the same of area of interest and displays them on the display. A user is allowed to simultaneously view representations of the same area of interest, where the representations are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.

Abstract: A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y-directions.

Abstract: The present invention provides a slide viewer capable of simultaneous display of more than one scan of an area of interest of a slide. The slide viewer includes a database containing at least two data files representing different scans for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same scan. The scans are views of different illumination and/or of different contrast. Associated with the database are a processor and a display. The processor retrieves data files representing different scans of the same of area of interest and displays them on the display. The present invention allows a user to simultaneously view scans of the same area of interest, where the scans are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.