Patents by Inventor Rainer E. Martin

Rainer E. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKERS FOR SITE-SPECIFIC ANTIBODY CONJUGATION
    Publication number: 20250262317
    Abstract: Herein is reported a polypeptide-linker-nucleic acid conjugate, wherein the linker comprises a 3-amino propanamide unit, a 2,6-diamino hexanoic acid amide unit, and a 1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d]-1,2,3-triazole unit, wherein the polypeptide comprises a C-terminal lysine residue, and wherein the nucleic acid comprises an oxygen linked to a phosphorous atom of the oxidation state V at 5? or 3? terminus, wherein the 3-amino group of the 3-amino propanamide unit and the carboxy function of the lysine residue of the polypeptide are linked by/form an amide bond, the carboxy function of the 3-amino propanamide unit and the alpha amino group of the 2,6-diamino hexanoic acid amide unit are linked by/form an amide bond, the 6-amino group of the 2,6-diamino hexanoic acid amide unit is a nitrogen of the 1,2,3-triazole element of the 1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d]-1,2,3-triazole unit, and the oxygen linked to the phosphorous atom of the nucleic acid is covalently l
    Type: Application
    Filed: January 21, 2025
    Publication date: August 21, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Kerstin HOFER, Mads MANSØ, Rainer E. MARTIN, Mohamed Yosry Hassan MOHAMED, Tobias OELSCHLAEGEL, Jacob RAVN, Felix Franz SCHUMACHER, Tatjana SELA
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20240383904
    Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: April 11, 2024
    Publication date: November 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Machoud AMOUSSA, Joerg BENZ, Julie Elisabeth Francoise BLAISING, Maude GIROUD, Uwe GRETHER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn Susannah O’HARA, Bernd PUELLMANN, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Matthias Beat WITTWER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20240199587
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: October 20, 2023
    Publication date: June 20, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Machoud AMOUSSA, Joerg BENZ, Niels Kevin BRIAN, Kallie FRISTON, Maude GIROUD, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Camiel John LEAKE, Rainer E. MARTIN, David Friedrich Erhard NIPPA, Fionn Susannah O’HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Shounan ZHANG
  • Heterocyclic compounds
    Patent number: 11981661
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: May 14, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
  • Heterocyclic compounds
    Patent number: 11814375
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: November 14, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
  • Site-specific antibody conjugation and its use
    Publication number: 20230310641
    Abstract: The present invention relates to a modified antibody comprising a heavy chain and a light chain, wherein the heavy chain or/and the light chain comprises one or more first recognition site(s) for the transglutaminase from Kutzneria albida (KalbTG) or a functionally active variant thereof. The one or more first recognition site(s) are introduced at one or more selected position(s) within the antibody's heavy chain and/or light chain. The invention further relates to one or more nucleic acids encoding the modified antibody according to the invention as well as a covalent conjugate comprising (i) the modified antibody according to the invention and (ii) one or more non-antibody moieties (payload(s)) covalently conjugated to the one or more first recognition site(s) either directly or via a first linker. In certain embodiments, the non-antibody moiety comprises a therapeutic entity and optionally a second linker.
    Type: Application
    Filed: December 22, 2022
    Publication date: October 5, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Kerstin HOFER, Rainer E. MARTIN, Mohamed Yosry Hassan MOHAMED, Tobias OELSCHLAEGEL, Felix Franz SCHUMACHER, Tatjana SELA
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20230203056
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Philipp SCHMID
  • BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20230024096
    Abstract: The invention provides bifunctional compounds of formula (I) or a pharmaceutically acceptable salt thereof. Formula (I). The compounds cause the degradation of SMARCA2 via the targeted ubiquination of SMARCA2 protein and subsequent proteasomal degradation and are thus useful for the treatment of cancer. The targeting ligand is of formula (TL).
    Type: Application
    Filed: October 28, 2020
    Publication date: January 26, 2023
    Inventors: Martin DUPLESSIS, Delphine GAUFRETEAU, Roman HUTTER, Eleonora JOVCHEVA, Bernd KUHN, Kiel LAZARSKI, Yanke LIANG, Thomas LUEBBERS, Laetitia Janine MARTIN, Rainer E. MARTIN, Barbara Johanna MUELLER, Roger NORCROSS, Philipp SCHMID, Jean-Yves WACH
  • BIFUNCTIONAL COMPOUNDS
    Publication number: 20230002367
    Abstract: The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.
    Type: Application
    Filed: October 26, 2020
    Publication date: January 5, 2023
    Inventors: Delphine GAUFRETEAU, Roman HUTTER, Eleonora JOVCHEVA, Bernd KUHN, Thomas LUEBBERS, Rainer E. MARTIN, Laetitia Janine MARTIN, Barbara Johanna MUELLER, Roger NORCROSS, Fabienne RICKLIN, Philipp SCHMID, Jean-Yves WACH, Juergen WICHMANN, Martin DUPLESSIS, Kiel LAZARSKI, Yanke LIANG
  • Phenoxymethyl derivatives
    Patent number: 11352330
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 7, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Holger Kuehne, Thomas Luebbers, Rainer E. Martin, Patrizio Mattei, Werner Neidhart, Hans Richter, Markus Rudolph, Emmanuel Pinard
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220106328
    Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O`HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220098176
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: September 2, 2021
    Publication date: March 31, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20210094972
    Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: September 22, 2020
    Publication date: April 1, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O`HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20210094943
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and RI to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2020
    Publication date: April 1, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O`HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • PHENOXYMETHYL DERIVATIVES
    Publication number: 20200339522
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 6, 2020
    Publication date: October 29, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome HERT, Daniel HUNZIKER, Holger KUEHNE, Thomas LUEBBERS, Rainer E. MARTIN, Patrizio MATTEI, Werner NEIDHART, Hans RICHTER, Markus RUDOLPH, Emmanuel PINARD
  • BICYCLIC QUINAZOLINONE DERIVATIVES
    Publication number: 20200317624
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Application
    Filed: February 18, 2020
    Publication date: October 8, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jerome HERT, Daniel HUNZIKER, Christoph KURATLI, Rainer E. MARTIN, Patrizio MATTEI, Alexander Lee SATZ
  • Bicyclic quinazolinone derivatives
    Patent number: 10676446
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 9, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Christoph Kuratli, Rainer E. Martin, Patrizio Mattei, Alexander Lee Satz
  • Phenoxymethyl derivatives
    Patent number: 10640472
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: May 5, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Holger Kuehne, Thomas Luebbers, Rainer E. Martin, Patrizio Mattei, Werner Neidhart, Hans Richter, Markus Rudolph, Emmanuel Pinard
  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
    Patent number: 10457685
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • [1,2,3]triazolo[4,5-d]pyrimidine derivatives
    Patent number: 10457684
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal