Abstract: Glycoproteins containing high mannose oligosaccharides are obtained and used to generate antibody to the mannose portion of the molecule. Such antibodies can be used in a diagnostic assay. The glycoproteins can be used to generate neutralizing antibody.

Abstract: A projector for projecting light onto a projection surface includes a first group (1) with a negative meniscus, a second group (2) with positive refractive power, a third group (3) with a single lens, a fourth group (4) with a lens with positive refractive power, and a field lens (5) with positive refractive power, such that the light passes through the projection objective from the fourth to the first group. In order to be provide a high image quality with a small number of optical components and the smallest dimensions, the projector is configured so the common focal width of the fourth group (4) and the field lens (5) is smaller than twice the image circle diameter (9) of the projection objective and the maximum free diameter (8) is smaller than the overall focal width, and in particular smaller than 0.8 times the overall focal width of the projection objective.

Abstract: The present invention is related to a peptide having an amino acid sequence comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein, whereby the peptide is suitable to act as a cell-penetrating peptide.

Abstract: A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells.

Abstract: Resistive-sensors are provided wherein networks or nanoframeworks of conducting polymer nanowires are electrochemically grown from pre-polymer solutions in the junction gap located between electrode pairs.

Abstract: Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclonal antibody Guy's 13. Like the parent antibody, these derivatives bind specifically to SAI/II, the surface adhesin of Streptococcus and the human diabody derivative is capable of aggregating streptococcal cells, making it a useful candidate therapeutic agent for passive immunization against oral diseases.

Abstract: A synthetic, soluble, endogenous complex formed from at least one component A and at least one component B, whereby component A comprises a binding domain for extra-cellular surface structures that internalize upon binding of component A of said complex, and component B has a constitutive catalytic kinase activity and effects cell biosynthesis/signalling including cell death after internalization. The complex allows to influence the growth and the physiology of cells. In particular said complex, nucleic acid molecules encoding it, cells transfected or transformed with these nucleic acid molecules are usable for the preparation of medicaments for the treatment of proliferative diseases, inflammatory diseases, allergies and autoimmune diseases.

Abstract: A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the vectors of the composition of the invention into the genome of a plant, plant cell or plant cell tissue and a transgenic plant cell comprising stably integrated into the genome a polynucleotide or vector of the invention or the vectors of the composition of the invention.

Abstract: The present invention relates to a method for identifying compounds that affect a transport of a receptor of interest through a specific membrane trafficking pathway mediated by said receptor within the context of a generic membrane trafficking pathway, which generic pathway is not mediated by said receptor, characterised by the following steps: d) monitoring the transport of the receptor of interest in a cell in the presence of the compound, wherein the receptor is labelled with a first marker, e) monitoring the transport of a second marker through the generic membrane trafficking pathway in a cell in the presence of the compound, f) comparing the results obtained from steps a) and b) and thereby identifying a compound affecting the specific membrane trafficking pathway. Furthermore it relates to the generation of a compound database using the method according to the invention as well as to the compound database itself.

Abstract: A piston for an internal combustion engine has a piston crown, a circumferential top land, and a circumferential ring belt having ring grooves, as well as having a piston skirt that has two skirt walls disposed on the major thrust side and the minor thrust side of the piston, and two box walls, set back with regard to the ring belt, that connect the skirt walls. The box walls have pin bosses with pin bores. The skirt wall disposed on the major thrust side is shorter, in a circumference direction of the piston, than the skirt wall disposed on the minor thrust side.

Abstract: Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclonal antibody Guy's 13. Like the parent antibody, these derivatives bind specifically to SAI/II, the surface adhesin of Streptococcus and the human diabody derivative is capable of aggregating streptococcal cells, making it a useful candidate therapeutic agent for passive immunization against oral diseases.

Abstract: A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the vectors of the composition of the invention into the genome of a plant, plant cell or plant cell tissue and a transgenic plant cell comprising stably integrated into the genome a polynucleotide or vector of the invention or the vectors of the composition of the invention.

Abstract: A method is described for altering the properties such as the accumulation, the stability and/or integrity, the subcellular localisation, the post-translational modifications, the ability to get purified, and the phase partitioning behaviour of natural or recombinant target proteins expressed in a host organism. The method involves the co-expression of natural or recombinant proteins along with a specific binding partner that sequesters the target recombinant protein into a complex. The binding partner is supplied as a separate protein allowing formation of intermolecular complexes or is fused to the protein of interest, allowing the formation of intramolecular complexes. The binding partner can also be used to alter the subcellular localisation without modifying the sequence or structure of the target protein itself.

Abstract: This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention.

Abstract: The invention relates to biochips for documenting of specific molecule-molecule interactions or cell-molecule interactions, more particularly unknown singular protein interactions. The invention also relates to corresponding methods for selecting and characterizing molecules, especially polypeptides and the complementary binding molecules.

Abstract: The present invention is drawn to a fusion protein containing at least one binding domain that specifically recognizes an eptitope of a plant pathogen and at least one additional domain made from a protein or peptide sequence which is toxic to the pathogen or detrimental the replication, transmission or life cycle of the pathogen. The present invention is further drawn to a pathogenocide made from the binding domain, a cellular targeting sequence and/or membrane localization sequence that leads to membrane anchoring. The present invention is further drawn to nucleotide sequences encoding fusion proteins and pathogenocides and to vectors containing the nucleotide sequences; as well as methods of making the fusion proteins and pathogencides and methods of making pathogen resistant plants, plant cells, or plant tissues with the fusion proteins and pathogenocides.

Abstract: An expansible fixing plug (10) has an expansion screw (14), which is located in an expansible fixing plug sleeve (12). In accordance with the invention, a screw thread (30) is of saw tooth construction and a rear part (16) of the fixing plug sleeve (12) is axially extendable. When the expansible fixing plug (10) is subjected to axial loading the expansion screw (14) moves axially in the fixing plug sleeve (12) and the screw thread (30) expands the fixing plug sleeve (12). The expansible fixing plug (10) therefore has a subsequent-expansion behavior when a drilled hole becomes enlarged. The expansible fixing plug (10) can be mounted by hammering in without turning the expansion screw (14). The core diameter of the screw thread (30) enlarges from the front to the rear to increase the capacity of the expansion screw (14) to withstand transverse loading.

Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula (I) 1

Abstract: The invention relates to an expansible fixing plug (10) having an expansion screw (14), which is located in an expansible fixing plug sleeve (12). In accordance with the invention, a screw thread (30) is of saw tooth construction and a rear part (16) of the fixing plug sleeve (12) is axially extendable. When the expansible fixing plug (10) is subjected to axial loading the expansion screw (30) moves axially in the fixing plug sleeve (12) and the screw thread (30) expands the fixing plug sleeve (12). The expansible fixing plug (10) therefore has a subsequent-expansion behaviour when a drilled hole becomes enlarged. A further advantage of the invention is the mounting of the expansible fixing plug (10) by hammering in without turning the expansion screw (14). The core diameter of the screw thread (30) enlarges from the front to the rear to increase the capacity of the expansion screw (14) to withstand transverse loading. (FIG. 5).

Abstract: Rice, wheat and other monocotyledonous plants are transformed with expression cassettes for production of mammalian polypeptides, such as antibodies. Endoplasmic reticulum (ER) retention signals, 5′ untranslated regions and leader peptides are employed in various combinations to provide high expression yield. Multi-chain complexes such as four-chain secretory antibodies are produced by expression of component polypeptides from separate vectors all introduced into the same cell by transformation.