Abstract: A filter system is for the local attenuation of X-radiation. In an embodiment, the filter system includes a filter device, arranged in a beam path of an X-ray apparatus and including a channel arrangement, the channel arrangement including a multiplicity of channel sections extending in parallel on a plane; a supply device to provide a 2-phase fluid flow containing drops of an absorber liquid, to absorb X-radiation and a carrier liquid transparent to X-radiation; and a sorting section, including an input connected to the supply device, a first output connected to the channel arrangement, a second output, and a deflection device to direct individual drops of the absorber liquid to the first output or the second output.

Abstract: A filter system is for the local attenuation of X-radiation. In an embodiment, the filter system includes a filter device, arranged in a beam path of an X-ray apparatus and including a channel arrangement, the channel arrangement including a multiplicity of channel sections extending in parallel on a plane; a supply device to provide a 2-phase fluid flow containing drops of an absorber liquid, to absorb X-radiation and a carrier liquid transparent to X-radiation; and a sorting section, including an input connected to the supply device, a first output connected to the channel arrangement, a second output, and a deflection device to direct individual drops of the absorber liquid to the first output or the second output.

Abstract: A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of the substrate in a fluid-tight manner by means of a clamping element. The clamping element and/or the valve body, or the sealing element, respectively, are at least partially elastic.

Abstract: A measurement channel for use in a microfluidic system, particularly a lab-on-chip system, having a first end at which a first gas permeable but liquid impermeable wall section is disposed which makes available a gas conduit, and a second end at which the measurement channel is connectable to at least one fluid conduit and at which an isolation or cutoff device is disposed, wherewith in the measurement channel a defined volume is included between the wall section and the isolation or cutoff device. A microfluidic structure is disclosed having a plurality of fluid conduits, and further having a valve for selectively connecting and/or blocking the fluid conduits, at least one of which fluid conduits is in the form of a measurement channel. A method of measuring and/or positioning a volume of a liquid in a microfluidic system, by a measurement channel is disclosed.

Abstract: The present invention provides an integrated lab-on-a-chip device for carrying out a nucleic acid extraction process on a fluid sample containing cells and/or particles, the device comprising: (a) a sample inlet (1) for loading of a fluid sample, (b) a lysis unit (4) for lysis of cells and/or particles present in the fluid sample, (c) a reservoir of lysis fluid (7) for the lysis unit, (d) a nucleic acid extraction unit (5) downstream of the lysis unit, and (e) reservoirs of first washing buffer and eluant fluid (8, 9, 10) for the nucleic acid extraction unit, wherein the device further comprises (f) a mixing unit (6) downstream of the nucleic acid extraction unit, and (g) a source of mixing fluid (11) for the mixing unit. The reservoirs of lysis fluid, first washing buffer and eluant fluid may be provided parallel to one anther so that they may be actuated by a single pump.

Abstract: A chip for performing and measuring chemical reactions, interactions (bonds), and/or conformational changes, especially fast chemical reactions and processes. The chip includes a base plate, which is made of a polymer material that is transparent at least in the measuring zone, and having. fluid ducts parallel to the plane of the base plate and includes at least two reagent feeders leading into a mixer structure that has a number of inlets corresponding to the number of reagent feeders and an outlet leading into a mixing section, the outlet of the mixing section leads into a measuring section, the outlet of the measuring section is connected to a discharge section, the discharge section leads out of the base plate or into a reservoir that is arranged on the chip, and pressure conduits lead into the reagent feeders at a distance from the mixer structure.

Abstract: A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of the substrate in a fluid-tight manner by means of a clamping element. The clamping element and/or the valve body, or the sealing element, respectively, are at least partially elastic.

Abstract: A measurement channel for use in a microfluidic system, particularly a lab-on-chip system, having a first end at which a first gas permeable but liquid impermeable wall section is disposed which makes available a gas conduit, and a second end at which the measurement channel is connectable to at least one fluid conduit and at which an isolation or cutoff means is disposed, wherewith in the measurement channel a defined volume is included between the wall section and the isolation or cutoff means. The isolation or cutoff means is preferably in the form of a second gas permeable but liquid impermeable wall section which makes available a gas conduit. A microfluidic structure is disclosed having a plurality of fluid conduits, and further having a valve for selectively connecting and/or blocking the fluid conduits, at least one of which fluid conduits is in the form of a measurement channel.

Abstract: The present invention provides an integrated lab-on-a-chip device for carrying out a nucleic acid extraction process on a fluid sample containing cells and/or particles, the device comprising: (a) a sample inlet (1) for loading of a fluid sample, (b) a lysis unit (4) for lysis of cells and/or particles present in the fluid sample, (c) a reservoir of lysis fluid (7) for the lysis unit, (d) a nucleic acid extraction unit (5) downstream of the lysis unit, and (e) reservoirs of first washing buffer and eluant fluid (8, 9, 10) for the nucleic acid extraction unit, wherein the device further comprises (f) a mixing unit (6) downstream of the nucleic acid extraction unit, and (g) a source of mixing fluid (11) for the mixing unit. The reservoirs of lysis fluid, first washing buffer and eluant fluid may be provided parallel to one anther so that they may be actuated by a single pump.