Patents by Inventor Rainer Gross

Rainer Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-bicyclically substituted dihydropyridines, and their use in medicaments
    Patent number: 5721248
    Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: February 24, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Siegfried Goldmann, Jurgen Stoltefuss, Martin Bechem, Klaus Dembowsky, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 3-quinolyl-substituted dihydropyridines, and their use in medicaments
    Patent number: 5629320
    Abstract: This invention relates to 3-quinolyl-substituted dihydropyridine derivatives, such as ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are used in treating cardiovascular disease.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 13, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: J urgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim H utter, Howard-Paul Rounding
  • 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments
    Patent number: 5550245
    Abstract: Intermediate of the formula ##STR1## wherein R.sup.5 represents a cyclic, straight-chain or branched, saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, which is optionally interrupted up to twice in an identical or different manner by oxygen or sulphur, as intermediates for substituents on novel dihydropyridine cardiovascular compounds.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 27, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: J urgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim H utter, Howard-Paul Rounding
  • 4-bicyclically substituted dihydropyridines and their use in medicaments
    Patent number: 5545646
    Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: August 13, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Siegfried Goldmann, J urgen Stoltefuss, Martin Bechem, Klaus Dembowsky, Rainer Gross, Siegbert Hebisch, Joachim H utter, Howard-Paul Rounding
  • 2,6-disubstituted 4-quinolyl-dihydropyridines
    Patent number: 5514803
    Abstract: The invention relates to new 2,6-disubstituted 4-quinolyl-dihydropyridines ##STR1## in which R.sub.1 to R.sub.5 have the meaning indicated in the description,processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: May 7, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • Quinolyl-dihydropyridine esters, processes for their preparation, and their use in medicaments
    Patent number: 5508406
    Abstract: The invention relates to new 4-quinolyl-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.6 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: April 16, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 3-quinolyl-substituted dihydropyridines and their use in medicaments
    Patent number: 5504210
    Abstract: The invention relates to new 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: April 2, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 2-amino-5-cyano-4-quinolydihydropyridine esters, processes for their preparation and their use in medicaments
    Patent number: 5504209
    Abstract: The present invention relates to new 2-amino-5-cyano-4-quinolyl-l, 4-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: April 2, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 2-amino-4-quinolyl-dihydropyridines, processes for their preparation, and their use
    Patent number: 5502062
    Abstract: The present invention relates to new 2-amino-4-quinolyl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 -R.sub.4 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: March 26, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ju/ rgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hu/ tter, Howard-Paul Rounding
  • Condensed quinolyl-dihydropyridines, processes for their preparation and their use in medicaments
    Patent number: 5436342
    Abstract: The invention relates to novel, condensed 4-quinolyl-dhydropyridines of the general formula (I) ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in agents for treating angiocardiopathies.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: July 25, 1995
    Assignee: Bayer Aktiengelsellschaft
    Inventors: Siegfried Goldman, Jurgen Stoltefuss, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments
    Patent number: 5434153
    Abstract: The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: July 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Siegfried Goldmann, Jurgen Stoltefuss, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine derivatives
    Patent number: 5432282
    Abstract: The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: July 11, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Horst Boshagen, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical composition and use
    Patent number: 5420142
    Abstract: The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: May 30, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Gerhard Franckowiak, Horst Boshagen, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding, Matthias Schramm
  • Intermediate benzothiazolyl- and benzoxazolyl-aldehyde compounds
    Patent number: 5412099
    Abstract: Intermediate compounds of formula IIR.sup.3 --CHO (II)wherein R.sup.3 is ##STR1## and R.sup.6 and R.sup.7 are as defined in the specification, are useful to make compounds having cardiovascular activity.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: May 2, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Horst Boshagen, Jurgen Stoltefuss, Alexander Straub, Rainer Gross, Joachim Hutter, Siegbert Hebisch, Martin Bechem
  • 3-phenyl-1,7-naphthyridine and cinnoline-5-carboxyaldehyde intermediates for medicaments
    Patent number: 5410055
    Abstract: The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and intermediates thereof and to their use in medicaments, in particular in compositions having positively inotropic action.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: April 25, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Jurgen Stoltefuss, Siegfried Goldmann, Rainer Gross, Martin Bechem, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation
    Patent number: 5380851
    Abstract: The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: January 10, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Horst Boshagen, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines, processes for their preparation and their use in medicaments
    Patent number: 5364855
    Abstract: The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in compositions having positively inotropic action.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: November 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Jurgen Stoltefuss, Siegfried Goldmann, Rainer Gross, Martin Bechem, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • Circulation-active dioxyalkylenearyl-dihydropyridines
    Patent number: 5344944
    Abstract: Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7,R.sup.7 is H, alkyl or various other radicals,R.sup.2 and R.sup.4 each independently is alkyl or other radicals,R.sup.3 is H or optionally substituted alkyl, andR.sup.5 completes a keto or ester group,and physiologically acceptable salts thereof.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: September 6, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Albrecht Marhold, Martin Bechem, Rainer Gross, Michael Kayser, Matthias Schramm, Gunther Thomas
  • Aryl-quinolyl-substituted 1,4-dihydropyridine-dicarboxylic acid compounds which have useful pharmaceutical utility
    Patent number: 5262429
    Abstract: The invention relates to novel aryl-quinolyl-substituted 1,4-dihydropyridine-di-carboxylic acid derivatives, to processes for their preparation and to their use in drugs, especially for the preparation drugs for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: November 16, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Rainer Gross, Martin Bechem, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
    Patent number: 5254692
    Abstract: 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## and R.sup.4 represents hydrogen, orand physiologically acceptable salts thereof.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: October 19, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Horst Boshagen, Jurgen Stoltefuss, Alexander Straub, Rainer Gross, Joachim Hutter, Siegbert Hebisch, Martin Bechem