Patents by Inventor Rainer Gruenbeck

Rainer Gruenbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for recombinant production of polypeptides
    Patent number: 7034119
    Abstract: A method for the recombinant production of a polypeptide by expressing a nucleic acid encoding said polypeptide in a microbial host cell, forming in the cytoplasm of said host cell inclusion bodies containing said polypeptide, and isolating, solubilizing and naturing said polypeptide, characterized in that after fermentation the host cell or the host cell content is incubated at a temperature of 40° C. or higher for at least 10 minutes and subsequently insoluble polypeptide is isolated from the host cell, this method providing an improved yield in inclusion bodies containing the desired polypeptide.
    Type: Grant
    Filed: June 12, 2004
    Date of Patent: April 25, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rainer Gruenbeck, Erhard Kopetzki, Friedrich Popp
  • Method for recombinant production of polypeptides
    Publication number: 20050003485
    Abstract: A method for the recombinant production of a polypeptide by expressing a nucleic acid encoding said polypeptide in a microbial host cell, forming in the cytoplasm of said host cell inclusion bodies containing said polypeptide, and isolating, solubilizing and naturing said polypeptide, characterized in that after fermentation the host cell or the host cell content is incubated at a temperature of 40° C. or higher for at least 10 minutes and subsequently insoluble polypeptide is isolated from the host cell, this method providing an improved yield in inclusion bodies containing the desired polypeptide.
    Type: Application
    Filed: June 12, 2004
    Publication date: January 6, 2005
    Inventors: Rainer Gruenbeck, Erhard Kopetzki, Friedrich Popp