Patents by Inventor Rainer Haag
Rainer Haag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230330234Abstract: It is provided a composition comprising a hyperbranched polyester polyol derivative and a small molecule comprising at least one cyclic amine. The hyperbranched polyester polyol derivative is obtainable by a method comprising the following steps: a) reacting only glycidol and ?-caprolactone at a temperature lying in a range of between 40° C. and 140° C. to obtain a hyperbranched polyester polyol derivative in which caprolactone residues and glycerol residues are randomly arranged; b) reacting the hyperbranched polyester polyol derivative of step a) with a sulfation reagent to obtain a sulfated hyperbranched polyester polyol as hyperbranched polyester polyol derivative.Type: ApplicationFiled: February 1, 2021Publication date: October 19, 2023Applicant: FREIE UNIVERSITÄT BERLINInventors: Rainer HAAG, Magda FERRARO, Ehsan MOHAMMADIFAR, Michael SCHIRNER
-
Publication number: 20230165891Abstract: The disclosure relates to dendritic polyglycerols (dPG) compounds with carboxyalkyl, sulfyl or sulfonyl functional groups that irreversibly inhibit viral infection (virucidal effect) through multivalent interaction in nanomolar concentration range. While the compounds of the disclosure show virus inhibition in the nanomolar range they show no in-vitro toxicity in the same range of concentration.Type: ApplicationFiled: January 27, 2023Publication date: June 1, 2023Inventors: Matteo GASBARRI, Francesco STELLACCI, Ehsan MOHAMMADIFAR, Rainer HAAG
-
Publication number: 20230080135Abstract: An amphiphilic copolymer includes a first block, a second block and a linker covalently linking the first block with the second block, wherein the first block is a hydrophilic dendritic polyglycerol derivative having a polyglycerol backbone and carrying a plurality of sulfate or sulfonate residues substituting hydroxyl groups of the polyglycerol backbone, wherein the second block is a hydrophobic block comprising a polymer chosen from the group consisting of polycaprolactone, a polylactic acid polymer, and a copolymer of lactic acid and glycolic acid. The linker comprises a hydrocarbon having at least six consecutive methylene residues and a cleavable entity. The linker is devoid of a triazole-containing residue resulting from a reaction between an alkyne and an azide.Type: ApplicationFiled: February 1, 2021Publication date: March 16, 2023Applicant: FREIE UNIVERSITÄT BERLINInventors: Rainer HAAG, Michael SCHIRNER
-
Publication number: 20220401565Abstract: It is provided a method of treatment of a human or animal patient in need thereof to achieve a reduction of the viscosity of mucus of the patient which is carried out by administering a polyglycerol derivative having a linear or dendritic polyglycerol backbone and carrying at least one thiol group covalently bound to the polyglycerol backbone. It is further provided a method of treatment of a human or animal patient suffering from chronic sinusitis, asthma, chronic bronchitis, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, bronchiectasis, chronic inflammatory bowel diseases, constipation, gastrointestinal malabsorption syndrome, irritable bowel syndrome, steatorrhea or diarrhea by administering a polyglycerol derivative. Further specific thiol-functionalized polyglycerol derivatives and a corresponding manufacturing method are provided.Type: ApplicationFiled: September 28, 2020Publication date: December 22, 2022Applicants: FREIE UNIVERSITÄT BERLIN, CHARITE - UNIVERSITAETSMEDIZIN BERLINInventors: Rainer HAAG, Marcus MALL, Daniel LAUSTER, Yinan ZHONG
-
Patent number: 11253599Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.Type: GrantFiled: December 8, 2016Date of Patent: February 22, 2022Assignee: DendroPharm GmbHInventors: Emanuel Fleige, Sam Moré, Michael Unbehauen, Rainer Haag, Christoph Stein, Halina Machelska-Stein, Florian Paulus
-
Publication number: 20210188902Abstract: A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.Type: ApplicationFiled: September 4, 2019Publication date: June 24, 2021Inventors: Carol V. Robinson, Idlir Liko, Hsin-Yung Yen, Kevin Pagel, Rainer Haag, Svenja Christina Ehrmann, Leonhard Hagen Urner
-
Patent number: 11041090Abstract: The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.Type: GrantFiled: June 30, 2017Date of Patent: June 22, 2021Assignee: FREIE UNIVERSITÄT BERLINInventors: Rainer Haag, Marie Weinhart, Qiang Wei, Leixiao Yu
-
Publication number: 20200385517Abstract: It is provided a method for manufacturing a hyperbranched polyester polyol derivative, comprising the following steps: a) reacting only glycidol and ?-caprolactone at a temperature lying in a range of between 40° C. and 140° C. to obtain a hyperbranched polyester polyol in which caprolactone residues are randomly arranged; b) reacting the hyperbranched polyester polyol of step a) with a sulfation reagent to obtain a sulfated hyperbranched polyester polyol as hyperbranched polyester polyol derivative.Type: ApplicationFiled: November 13, 2018Publication date: December 10, 2020Applicant: FREIE UNIVERSITÄT BERLINInventors: Rainer HAAG, Ehsan MOHAMMADIFAR, Magda FERRARO, Fatemeh ZABIHI, Mohsen ADELI
-
Patent number: 10738059Abstract: Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.Type: GrantFiled: February 27, 2017Date of Patent: August 11, 2020Assignee: Biolitec Unternehmensbeteiligungs II AGInventors: Michael Staegemann, Rainer Haag, Arno Wiehe, Susanna Graefe, Burkhard Gitter, Volker Albrecht
-
Publication number: 20200207921Abstract: It is provided a diblock copolymer consisting of a first block, a second block, and a linker, wherein the second block is covalently bound to the first block by the linker. Thereby, the first block is a glycerol block comprising 1 to 10 glycerol subunits that are optionally substituted, and the second block is a superhydrophobic block comprising a perfluoroether residue having at least 20 carbon atoms.Type: ApplicationFiled: July 24, 2018Publication date: July 2, 2020Applicants: FREIE UNIVERSITÄT BERLIN, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Rainer HAAG, Mohammad Suman CHOWDHURY, David WEITZ
-
Patent number: 10525141Abstract: It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.Type: GrantFiled: April 15, 2016Date of Patent: January 7, 2020Assignee: FREIE UNIVERSITÄT BERLINInventors: Rainer Haag, Sabine Reimann, Jens Dernedde
-
Patent number: 10392474Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.Type: GrantFiled: January 20, 2016Date of Patent: August 27, 2019Assignees: FREIE UNIVERSITAET BERLIN, THE UNIVERSITY OF BRITISH COLUMBIAInventors: Donald Brooks, Jayachandran Kizhakkedathu, Rajesh Shenoi, Marie Weinhart, Benjamin Lai, Rainer Haag, Dominic Groeger
-
Publication number: 20190169463Abstract: The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.Type: ApplicationFiled: June 30, 2017Publication date: June 6, 2019Applicant: FREIE UNIVERSITÄT BERLINInventors: Rainer HAAG, Marie WEINHART, Qiang WEI, Leixiao YU
-
Publication number: 20180344857Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.Type: ApplicationFiled: December 8, 2016Publication date: December 6, 2018Inventors: Emanuel Fleige, Sam Moré, Michael Unbehauen, Rainer Haag, Christoph Stein, Halina Machelska-Stein, Florian Paulus
-
Patent number: 10047230Abstract: An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.Type: GrantFiled: September 8, 2014Date of Patent: August 14, 2018Assignee: FREIE UNIVERSITÄT BERLINInventors: Rainer Haag, Marie Weinhart, Qiang Wei, Tobias Becherer, Ingo Grunwald
-
Publication number: 20180092982Abstract: It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.Type: ApplicationFiled: April 15, 2016Publication date: April 5, 2018Applicant: FREIE UNIVERSITÄT BERLINInventors: Rainer HAAG, Sabine REIMANN, Jens DERNEDDE
-
Publication number: 20180009943Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.Type: ApplicationFiled: January 20, 2016Publication date: January 11, 2018Applicants: FREIE UNIVERSITAET BERLIN, THE UNIVERSITY OF BRITISH COLUMBIAInventors: Donald BROOKS, Jayachandran KIZHAKKEDATHU, Rajesh SHENOI, Marie WEINHART, Benjamin LAI, Rainer HAAG, Dominic GROEGER
-
Patent number: 9770420Abstract: A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.Type: GrantFiled: September 5, 2013Date of Patent: September 26, 2017Assignee: FREIE UNIVERSITÄT BERLINInventors: Rainer Haag, Dirk Steinhilber, Wolfgang Friess, Sarah Küchler, Madeleine Witting
-
Publication number: 20170247384Abstract: Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.Type: ApplicationFiled: February 27, 2017Publication date: August 31, 2017Inventors: Michael Staegemann, Rainer Haag, Arno Wiehe, Susanna Graefe, Burkhard Gitter, Volker Albrecht
-
Patent number: 9682098Abstract: The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.Type: GrantFiled: July 20, 2015Date of Patent: June 20, 2017Assignees: Ramot at Tel-Aviv University Ltd., Freie Universitaet BerlinInventors: Rainer Haag, Wiebke Fischer, Abdul Mohiuddin Quadir, Ronit Satchi-Fainaro, Paula Ofek