Abstract: The invention refers to an implant device, in particular to a pubic symphysis implant device, and to an implant system comprising two such implant devices. The implant device of the invention comprises a bent body comprising a curved middle portion and two lateral arms extending away from the middle portion and being mutually joined by the middle portion, and at least one guiding element defining at least one guiding path along which a tensioning element can be guided. The invention further refers to method of fixating together a first bone or bone part and a second bone or bone part, for example for re-joining a disjoined pubic symphysis, using such an implant system, in particular by placing each of the two implant devices on corresponding bones or bone parts and by pulling the two implant devices towards each other by tensioning a tensioning element guided along the at least one guiding path of each of the two implant devices.

Abstract: A copolymer includes a first structural unit selected from Chemical Formula 1, Chemical Formula 2, and a combination thereof and a second structural unit selected from Chemical Formula 3, Chemical Formula 4, and a combination thereof; and a composition including the copolymer and an article manufactured from the composition are provided. Definitions of Chemical Formulae 1 to 4 are the same as described in the detailed description.

Abstract: A copolymer includes a first structural unit selected from Chemical Formula 1, Chemical Formula 2, and a combination thereof and a second structural unit selected from Chemical Formula 3, Chemical Formula 4, and a combination thereof; and a composition including the copolymer and an article manufactured from the composition are provided. Definitions of Chemical Formulae 1 to 4 are the same as described in the detailed description.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.

Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: In a process for polmerizing a mixture comprising at least one free-radically polymerizable monomer and a transition metal complex whose transition metal is capable of reversibly binding a halogen atom, thus bringing about a change in the oxidation state of the transition metal from a first oxidation state to a second, in the presence of an initiator R-Y, where Y is halogen and R is alkyl, substituted alkyl, cycloalkyl (substituted or unsubstituted), aryl or —CHnHal3-n, where n=0 to 2 and Hal=halogen, in an aqueous system, the transition metal is bound via suitable anchor groups to the hydrophobic part of an amphiphilic polymer which is made up of a hydrophilic part and a hydrophobic part. Also provided are a corresponding transition metal complex, a reaction product which can be prepared by this process and the use of this transition metal complex for preparing reaction products by free-radical polymerization.