Abstract: The present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions, for use in a method of topical treatment of a skin disease or skin disorder of a mammal, wherein said method comprises topical administration of said compound to said mammal, Formula (I) wherein R1 is selected from carbocyclyl or heterocyclyl, each independently optionally substituted with C1-C4alkyl, halogen, oxo, CF3, OR4, NR5R6, C6H5, C6H5 substituted with halogen, C1-C3alkyl, OR4, NR5R6, wherein R4, R5, R6 are independently at each occurrence H, C1-C3alkyl; R2 is selected from C5-C12alkyl, C4-C10alkoxy, C1-C3 alkylene-cycloalkyl, C1-C3alkylene-aryl, C1-C3alkylene-heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more, typically and preferably one or two, substituents selected from C1-C2 alkyl, C1-C2 haloalkyl, halogen, C1-C2 alkoxy; R3 is (Ia), wherein R7, R8, R9 and R10 are independently at eac

Abstract: A method is provided for simulating a control device, on which a software is executed, on a computer platform having a hardware which is to be actuated via hardware drivers, the hardware drivers being connected via an interface to the software of the control device, the method including: in a first step, the hardware is recognized; and in a subsequent step, a microcontroller abstraction layer is generated on the computer platform, in which the interface is customized to the hardware drivers present; at least one plugin being produced for at least one hardware driver.