Patents by Inventor Rainer Knoerle

Rainer Knoerle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level
    Patent number: 6984659
    Abstract: 2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polygltamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: January 10, 2006
    Assignee: Klinikum der Albert-Ludwigs Universitaet
    Inventors: Thomas J. Feuerstein, Rainer Knoerle
  • 2-Pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level
    Publication number: 20050228035
    Abstract: 2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polyglutamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.
    Type: Application
    Filed: June 1, 2005
    Publication date: October 13, 2005
    Applicant: KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITAET
    Inventors: Thomas Feuerstein, Rainer Knoerle
  • 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level
    Publication number: 20020173537
    Abstract: 2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polygltamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.
    Type: Application
    Filed: March 29, 2002
    Publication date: November 21, 2002
    Inventors: Thomas J. Feurerstein, Rainer Knoerle
  • Position-4 substituted 2-pyrrolidinone derivatives to reduce the level of extracellular glutamate
    Patent number: 6384069
    Abstract: 2-Pyrrolidinone derivatives substituted in position 4 are provided according to the invention for use as therapeutic active ingredient. It has been found, surprisingly, that these compounds are able markedly to reduce the extracellular glutamate level, and the compounds are therefore suitable for the prophylaxis and treatment of a large number of disorders, in particular, stroke.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: May 7, 2002
    Assignee: Klinikum der Albert-Ludwigs-Universitaet
    Inventors: Thomas J. Feuerstein, Rainer Knoerle