Abstract: The invention provides purified human metabotropic glutamate receptors, compositions comprising such receptors, and nucleic acids that encode such receptors.

Abstract: The invention relates to the use of an inhibitor of formula (I), or a pharmaceutically acceptable salt thereof having an activity on protein kinases PKC alpha, PKC beta, PKC gamma, PKC epsilon, PKC theta, CDK-1, KDR, PKA, Flt-1, Flt-2, Flt-3 or Flt-4, or on a combination of the above enzymes, for the treatment and/or prevention of neurological and vascular disorders related to beta-amyloid generation and/or aggregation such as neurodegenerative diseases like Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, or cerebral hemorrhage with amyloidosis.

Abstract: Two methods are provided for selecting the QoS level during a connection between a first media gateway which is associated with a first subscriber and a first network operation, and a second media gateway which is associated with a second subscriber and possibly a second network operation, either in a packet network via an exchange by a CODEC or in a network via an exchange by a transmission technique. In such methods, the first subscriber and/or the first network operator signals to a first media gateway controller that they would like another QoS. During the first method, a CODEC used in the connection is modified via the first and second media gateways and two media gateway controllers. During the second method, an IP connection is deviated towards a TDM connection, or vice versa, via additional TDM endpoints and the aforementioned components. It is thus possible to adapt the QoS level to the level currently required.

Abstract: A compound of formula I wherein X represents an optionally halo-substituted (C2-4)alkynylene group bonded via vicinal unsaturated carbon atoms.

Abstract: The invention provides purified human metabotropic glutamate receptors, compositions comprising such receptors, and nucleic acids that encode such receptors.

Abstract: The present invention relates to human metabotropic glutamate receptor (hmGluR) proteins, isolated nucleic acids coding therefor, host cells producing the proteins of the invention, methods for the preparation of such proteins, nucleic acids and host cells, and uses thereof.

Abstract: The present invention relates to human metabotropic glutamate receptor (hmGluR) proteins, isolated nucleic acids coding therefor, host cells producing the proteins of the invention, methods for the preparation of such proteins, nucleic acids and host cells, and uses thereof.

Abstract: The invention provides the use of selective mGluR5 antagonists for the treatment of pain and anxiety, and the use of mGluR antagonists for the treatment of pain, whereby analgesic effect is achieved by interaction of said antagonists primarily or predominantly at peripheral mGluR receptors.

Abstract: The present invention relates to human metabotropic glutamate receptor (hmGluR) proteins, isolated nucleic acids coding therefor, host cells producing the proteins of the invention, methods for the preparation of such proteins, nucleic acids and host cells, and uses thereof.

Abstract: A conduit vibration decoupling device, particularly for installation in exhaust conduit systems of internal combustion engines, comprises a pair of axially spaced conduit connector members connected with each other by a flexible bellows-type sealing conduit element, and a force transfer means having at least axial pliancy for transferring forces between the conduit connector members. The force transfer means comprises a housing extending between the conduit connector members along the flexible conduit element and connected near at least one of its axial ends by an articulated spring assembly comprising at least one annular spring element to the associated conduit connector member. The spring element extends around the periphery of the conduit connector member and can be either an annular disk-shaped element or an annular element made of a metallic cable material. The housing may be free of outer protruding parts thereby it may have an outer smooth, cylindrical configuration.

Abstract: Certain fluoromethylphenols, such as 3,5-bis-trifluoromethylphenol, are suitable solvents for LC-polymers. Many LC-polymers which have hitherto been regarded as insoluble in organic solvents can be brought into solution by means of these compounds. The polymers thereby become more easily analyzable and can be processed from solution.

Abstract: Laminate systems with improved bond strength prepared by coating of flexible substrates with low density polyethylene and a process for preparing said laminate systems are claimed which are characterized in that a polyethylene is used as a coating resin, which is obtained if(a) two autoclaves are connected in series such that all the reaction product of the first reactor is transferred to the second reactor,(b) a length-/diameter ratio (L/D) of 1:1 to 3:1 is chosen for each autoclave,(c) the monomer feed stream is distributed between the two reactors such that the monomer feed stream to the first reactor is the same as or greater than the monomer feed stream to the second reactor,(d) the reaction temperatures in the two autoclaves are adjusted such that the reaction temperature in the first reactor is lower than the reaction temperature in the second reactor,(e) the initiator chosen for the first reactor is the same as or different from the initiator chosen for the second reactor, and which has a density of 0