Patents by Inventor Rainer Machauer

Rainer Machauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxazine Derivatives and their Use in the Treatment of Neurological Disorders
    Publication number: 20120238560
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
    Type: Application
    Filed: April 24, 2012
    Publication date: September 20, 2012
    Applicant: NOVARTIS AG
    Inventors: Philipp HOLZER, Rainer MACHAUER, Marina TINTELNOT-BLOMLEY
  • Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders
    Publication number: 20120184539
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 19, 2012
    Inventors: Sangamesh BADIGER, Murali CHEBROLU, Konstanze HURTH, Sébastien JACQUIER, Rainer Martin LUEOEND, Rainer MACHAUER, Heinrich RUEEGER, Marina TINTELNOT-BLOMLEY, Siem Jacob VEENSTRA, Markus VOEGTLE
  • Oxazine Derivatives and their Use in the Treatment of Neurological Disorders
    Publication number: 20120172359
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
    Type: Application
    Filed: March 7, 2012
    Publication date: July 5, 2012
    Applicant: NOVARTIS AG
    Inventors: Sangamesh BADIGER, Murali CHEBROLU, Mathias FREDERIKSEN, Philipp HOLZER, Konstanze HURTH, Rainer Martin LUEOEND, Lei LI, Hui LIU, Rainer MACHAUER, Henrik MOEBITZ, Ulf NEUMANN, Rita RAMOS, Heinrich RUEEGER, Michael SCHAEFER, Siem Jacob VEENSTRA, Marina TINTELNOT-BLOMLEY, Markus VOEGTLE, Xin XIONG
  • Oxazine derivatives and their use in the treatment of neurological disorders
    Patent number: 8207164
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: June 26, 2012
    Assignee: Novartis AG
    Inventors: Philipp Holzer, Rainer Machauer, Marina Tintelnot-Blomley
  • Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors
    Patent number: 8093406
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: January 10, 2012
    Assignee: Novartis AG
    Inventors: Emmanuelle Briard, Rainer Martin Lueoend, Rainer Machauer, Henrik Moebitz, Olivier Rogel, Jean-Michel Rondeau, Heinrich Rueeger, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic compounds useful as BACE inhibitors
    Patent number: 8039455
    Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: October 18, 2011
    Assignee: Novartis AG
    Inventors: Claudia Betschart, Manuel Koller, Kurt Laumen, Andreas Lerchner, Rainer Machauer, Clive McCarthy, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic compounds and compositions useful as BACE inhibitors
    Patent number: 8008250
    Abstract: Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them are presented.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: August 30, 2011
    Assignee: Novartis AG
    Inventors: Andreas Lerchner, Rainer Machauer, Marina Tintelnot-Blomley, Oliver Simic
  • OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20110021520
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 27, 2011
    Inventors: Sangamesh BADIGER, Murali CHEBROLU, Mathias FREDERIKSEN, Philipp HOLZER, Konstanze HURTH, Rainer Martin LUEOEND, Rainer MACHAUER, Henrik MOEBITZ, Ulf NEUMANN, Rita RAMOS, Heinrich RUEEGER, Marina TINTELNOT-BLOMLEY, Siem Jacob VEENSTRA, Markus VOEGTLE
  • Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors
    Publication number: 20100056490
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: July 9, 2009
    Publication date: March 4, 2010
    Inventors: Emmanuelle Briard, Rainer Martin Lueoend, Rainer Machauer, Henrik Moebitz, Olivier Rogel, Jean-Michel Rondeau, Heinrich Rueeger, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic Lactams and Pharmaceutical Use Thereof
    Publication number: 20100022500
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 25, 2009
    Publication date: January 28, 2010
    Inventors: Yves AUBERSON, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer MacHauer, Marina Tintelnot-Blomley, Thomas J. Troxler, Siem Jacob Veenstra
  • MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS
    Publication number: 20090312370
    Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: July 20, 2007
    Publication date: December 17, 2009
    Inventors: Kurt Laumen, Rainer Machauer, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic lactams and pharmaceutical use thereof
    Patent number: 7612055
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: November 3, 2009
    Assignee: Novartis AG
    Inventors: Yves Auberson, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer Machauer, Marina Tintelnot-Blomley, Thomas J. Troxler, Siem Jacob Veenstra
  • MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS
    Publication number: 20090170878
    Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: July 19, 2007
    Publication date: July 2, 2009
    Inventor: Rainer Machauer
  • AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS
    Publication number: 20090054427
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: August 22, 2008
    Publication date: February 26, 2009
    Inventors: Emmanuelle Briard, Rainer Martin Lueoend, Rainer Machauer, Henrik Moebitz, Olivier Rogel, Jean-Michel Rondeau, Heinrich Rueeger, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • MACROCYCLIC COMPOUNDS USEFUL AS BASE INHIBITORS
    Publication number: 20090029960
    Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: December 28, 2006
    Publication date: January 29, 2009
    Inventors: Claudia Betschart, Manuel Koller, Kurt Laumen, Andreas Lerchner, Rainer Machauer, Clive McCarthy, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic Compounds and Compositions Useful as Bace Inhibitors
    Publication number: 20080214526
    Abstract: The invention relates to novel macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: January 13, 2006
    Publication date: September 4, 2008
    Applicant: NOVARTIS AG
    Inventors: Andreas Lerchner, Rainer Machauer, Marina Tintelnot-Blomley, Oliver Simic
  • Macrocyclic Compounds Useful as Bace Inhibitors
    Publication number: 20080132477
    Abstract: The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: January 13, 2006
    Publication date: June 5, 2008
    Inventors: Claudia Betschart, Andreas Lerchner, Rainer Machauer, Heinrich Rueger, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Macrocyclic lactams and pharmaceutical use thereof
    Publication number: 20070072792
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: November 4, 2004
    Publication date: March 29, 2007
    Inventors: Yves Auberson, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer Machauer, Marina Tintelnot-Blomley, Thomas Troxler, Siem Veenstra