Abstract: The present invention relates to methods for obtaining induced smooth muscle cells (iSMCs), iSMCs, iSMCs for use in a method of treating a disease or disorder or for use in tissue engineering, and the use of skeletal muscle derived cells for obtaining iSMCs.

Abstract: The present invention relates to methods for obtaining induced smooth muscle cells (iSMCs), iSMCs, iSMCs for use in a method of treating a disease or disorder or for use in tissue engineering, and the use of skeletal muscle derived cells for obtaining iSMCs.

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient.

Abstract: The present invention relates to myogenic progenitor cells (MFCs) for use in a method for the prevention and/or treatment of anal incontinence in a subject, wherein said subject is at risk to develop anal incontinence or suffers from anal incontinence for 20 years or less than 20 years, more preferably for about 6 months to about 20 years or for about 6 months to about 10 years. The present invention also refers to a pharmaceutical composition comprising MFCs and a pharmaceutical acceptable excipient and/or carrier for use in a method for the prevention and/or treatment of anal incontinence according to the present invention.

Abstract: The present invention relates to methods for obtaining skeletal muscle derived cells (SMDC), and the use of SMDCs in a method of preventing and/or treating neuromyopathies and/or myopathies, wherein the neuromyopathy and/or myopathy is incontinence, in particular a urinary and/or an anal or fecal incontinence.

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient.

Abstract: The present invention relates to methods for obtaining skeletal muscle derived cells (SMDC), and the use of SMDCs in a method of preventing and/or treating neuromyopathies and/or myopathies, wherein the neuromyopathy and/or myopathy is incontinence, in particular a urinary and/or an anal or fecal incontinence.

Abstract: The present invention relates to methods for obtaining induced smooth muscle cells (iSMCs), iSMCs, iSMCs for use in a method of treating a disease or disorder or for use in tissue engineering, and the use of skeletal muscle derived cells for obtaining iSMCs.

Abstract: The present invention relates to methods for obtaining skeletal muscle derived cells (SMDC), and the use of SMDCs in a method of preventing and/or treating neuromyopathies and/or myopathies, wherein the neuromyopathy and/or myopathy is incontinence, in particular a urinary and/or an anal or fecal incontinence.

Abstract: An injection device (100), provided for injection with an injection syringe (50) into an organism (1), comprises a guide device (10) designed to receive the injection syringe (50), wherein an injection needle (51) and a syringe body (52) of the injection syringe (50) can be moved relative to the guide device (10), in an advance movement towards or in a withdrawal movement away from the organism (1), and an actuating device (20) to which the injection syringe (50) can be coupled and which is used to actuate the injection syringe (50) for injection of an injectable substance into the organism (1), wherein the actuating device (20) has an actuating element (21) which forms an abutment for a piston device (53) of the injection syringe (50) on the guide device (10), in such a way that, during the withdrawal movement, the piston device (53) executes a relative movement counter to the injection needle (51) and the syringe body (52).

Abstract: The present invention relates to a potency assay for skeletal muscle derived cells (SMDC), the potency assay comprises the steps of (a) measuring ACh E activity of SMDC, and (b) evaluating the potential of the SMDC to be used for the treatment of skeletal muscle dysfunction based on the AChE activity measured in step (a). Moreover, the present invention relates to skeletal muscle derived cells (SMDC) for use in the treatment of a muscle dysfunction. Finally, the present invention relates to the use of AChE activity as an in vitro differentiation marker for skeletal muscle derived cells and to a kit for performing the potency assay according to the present invention.

Abstract: An injection device (100) for injecting a substance into an organism (1) is described, comprising a guide device (10) with a lumen (11) in which an injection tool (21) is arranged in a displaceable manner, a displacement device (20) to which the injection tool (21) is connected, and a holder device (30) that forms a support for the guide and displacement devices (10, 20), said guide and displacement devices (10, 20) being displaceably arranged on the holder device (30). A method for injecting a substance into an organism (1) is also described.

Abstract: An injection device (100), provided for injection with an injection syringe (50) into an organism (1), comprises a guide device (10) designed to receive the injection syringe (50), wherein an injection needle (51) and a syringe body (52) of the injection syringe (50) can be moved relative to the guide device (10), in an advance movement towards or in a withdrawal movement away from the organism (1), and an actuating device (20) to which the injection syringe (50) can be coupled and which is used to actuate the injection syringe (50) for injection of an injectable substance into the organism (1), wherein the actuating device (20) has an actuating element (21) which forms an abutment for a piston device (53) of the injection syringe (50) on the guide device (10), in such a way that, during the withdrawal movement, the piston device (53) executes a relative movement counter to the injection needle (51) and the syringe body (52).

Abstract: An ultrasonic probe with an ultrasonic head (K), which is arranged on or in a shaft (S) and is moveable with or in this shaft, and a positioning apparatus (P) for at least one examination or operating device is described, which is connected with the shaft. Also, medical operating apparatuses with examination probes and uses of the ultrasonic probe and the medical implements are described.

Abstract: An injection device (100) for injecting a substance into an organism (1) is described, comprising a guide device (10) with a lumen (11) in which an injection tool (21) is arranged in a displaceable manner, a displacement device (20) to which the injection tool (21) is connected, and a holder device (30) that forms a support for the guide and displacement devices (10, 20), said guide and displacement devices (10, 20) being displaceably arranged on the holder device (30). A method for injecting a substance into an organism (1) is also described.

Abstract: The present invention relates to methods of preventing or treating anal incontinence comprising injecting muscle-derived cells into a site of interest via an injection device, where the injection site of interest is, or is adjacent to, muscle-tissue providing for anal continence.

Abstract: A suspension composition is described, which contains at least one functional component effective in biological tissue and which forms a dosage form for administration into the tissue, whereby the functional component is suspended or dissolved in a suspension fluid, the functional component contains at least one active ingredient, biological cells, bacteria, viruses and/or biological or biocompatible fillers, and an ultrasound contrast medium is contained in the suspension fluid. Uses of the suspension composition, in particular for injection into biological tissue, are also disclosed.

Abstract: An ultrasonic probe with an ultrasonic head (K), which is arranged on or in a shaft (S) and is moveable with or in this shaft, and a positioning apparatus (P) for at least one examination or operating device is described, which is connected with the shaft. Also, medical operating apparatuses with examination probes and uses of the ultrasonic probe and the medical implements are described.