Patents by Inventor Rainer Metternich

Rainer Metternich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of trypsin-like enzymes
    Patent number: 5856306
    Abstract: Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue or a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L-configuration, are useful in therapeutic methods of inhibiting thrombin.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 5, 1999
    Assignee: Trigen, Limited
    Inventors: Goran Claeson, Manfred Hans Wilhelm Philipp, Rainer Metternich
  • Inhibitors of trypsin-like enzymes
    Patent number: 5574014
    Abstract: Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X=H or is an N-protecting group; Y is Phe-Pro; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L- configuration, are useful in therapeutic methods of inhibiting thrombin.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: November 12, 1996
    Assignee: Thrombosis Research Institute
    Inventors: Goran Claeson, Manfred H. W. Philipp, Rainer Metternich
  • Pseudopeptide isosteres of gly-asp and their use as antithrombic agents
    Patent number: 5561112
    Abstract: Pseudopeptides of formula I in free or salt form ##STR1## wherein A, B, R.sub.1, X, Y and m are defined as in claim 1, and their use in the prophylactic and acute treatment of thrombosis.
    Type: Grant
    Filed: March 1, 1994
    Date of Patent: October 1, 1996
    Assignee: Sandoz Ltd.
    Inventors: Georg Kottirsch, Rainer Metternich
  • Borolysine peptidomimetics
    Patent number: 5288707
    Abstract: Borolysine peptidomimetics of formula I ##STR1## wherein W, Y, R.sub.4, R.sub.5, Q.sub.1 and Q.sub.2 are defined in claim 1 are potent thrombin inhibitors.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: February 22, 1994
    Assignee: Sandoz Ltd.
    Inventor: Rainer Metternich