Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The present application relates to an aluminum alloy, in particular a cast aluminum alloy, a method for producing an engine component, in particular a piston for an internal combustion engine, in which an aluminum alloy is cast using the gravity die casting method, and an engine component, in particular a piston for an internal combustion engine, consisting at least partially of an aluminum alloy. The aluminum alloy consists of the following alloy elements: silicon: 10% by weight to <13% by weight, nickel: up to <0.6% by weight, copper: 1.5% by weight to <3.6% by weight, magnesium: 0.5% by weight to 1.5% by weight, iron: 0.1% by weight to 0.7% by weight, manganese: 0.1 to 0.4% by weight, zirconium: >0.1 to <0.3% by weight, vanadium: >0.08 to <0.2% by weight, titanium: 0.05 to <0.2% by weight, phosphorus: 0.0025 to 0.008% by weight, and the remainder being aluminum and unavoidable impurities. Furthermore, the microstructure of the alloy has spheroidized primary precipitates.

Abstract: A cast piston for an internal combustion engine is made of an iron-based material and has windows in at least one side wall carrying a piston pin boss. The windows are asymmetric relative to one another on the side of the skirt walls.

Abstract: A one-piece cast piston (10) for an internal combustion engine includes a cooling channel (12) and at least one rib (18) on the inner side of the piston opposite the recess base of a combustion bowl (14).

Abstract: A diesel engine piston is cast in one piece and consists of almost fully pearlitic cast iron with spheroidal graphite as the piston material. Such a piston is used for “light vehicle” diesel engines, “heavy duty” diesel engines and “large bore” diesel engines.

Abstract: The invention relates to a method for producing an engine component, in particular a piston for an internal combustion engine, wherein an aluminum alloy is cast in the gravity die casting process and wherein the aluminum alloy has 7 to <14.5 wt % silicon, >1.2 to ?4 wt % nickel, >3.7 to <10 wt % copper, <1 wt % cobalt, 0.1 to 1.5 wt % magnesium, 0.1 to ?0.7 wt % iron, 0.1 to ?0.7 wt % manganese, >0.1 to <0.5 wt % zirconium, ?0.1 to ?0.3 wt % vanadium, 0.05 to 0.5 wt % titanium, and 0.004 to ?0.05 wt % phosphorus as alloying elements and aluminum and unavoidable contaminants as the remainder. The aluminum alloy can optionally comprise beryllium, wherein the calcium content is limited to a low level.

Abstract: The present invention relates to a diesel engine piston which is cast in one piece and which consists of almost fully pearlitic cast iron with spheroidal graphite as the piston material. Moreover, the present invention relates to the use of such a diesel engine piston for “light vehicle” diesel engines, “heavy duty” diesel engines and “large bore” diesel engines.

Abstract: A cast piston for an internal combustion engine is made of an iron-based material and has windows in at least one side wall carrying a piston pin boss. The windows are asymmetric relative to one another on the side of the skirt walls.

Abstract: A one-piece cast piston (10) for an internal combustion engine includes a cooling channel (12) and at least one rib (18) on the inner side of the piston opposite the recess base of a combustion bowl (14).

Abstract: A piston including at least one insert disposed between an inner surface of a ring belt and undercrown surface, and/or between the inner surface of the ring belt and a pin boss, to provide reinforcement to the ring belt is provided. The insert reduces thermal and mechanical distortion of the ring belt, and thus increases the piston ring performance, reduces blow-by, and ultimately improves engine emissions. The insert is formed by an additive machining process, such as direct depositing, laser cladding, laser sintering, arc welding, additive welding, plasma transferred arc spraying, plasma welding, arc welding, selective laser sintering, and high velocity oxygen fuel spraying, plasma spraying. According to one embodiment, an intermediate piece is mechanically attached to the piston, and the insert is applied to the intermediate piece, to provide additional reinforcement.

Abstract: A method for producing an engine component, more particularly a piston for an internal combustion engine, in which an aluminum alloy is cast using the gravity die casting method is provided. The aluminum alloy comprises: 9 to ?10.5% by weight silicon, >2.0 to <3.5% by weight nickel, >3.7 to 5.2% by weight copper, <1% by weight cobalt, 0.5 to 1.5% by weight magnesium, 0.1 to 0.7% by weight iron, 0.1 to 0.4% by weight manganese, >0.1 to <0.2% by weight zirconium, >0.1 to <0.2% by weight vanadium, 0.05 to <0.2% by weight titanium, 0.004 to 0.008% by weight phosphorus, with aluminum and unavoidable impurities constituting the rest. An engine component, in particular a piston, wherein the engine component consists, at least partially, of the aluminum alloy, and the use of an aluminum alloy to produce the engine component, is also provided.

Abstract: A power semiconductor device comprises a substrate; and power semiconductor components disposed on and connected thereto. The device includes a housing part with a housing wall having a first cutout. The device has, for making electrical contact therewith, a unitary load connection element which passes through the first cutout in an X direction, is electrically conductive, and has an outer connection section disposed outside the housing part and an inner connection section disposed within the housing part. A first bush which has an internal thread running in the X direction is rotationally fixed and movable in the X direction in the housing wall. The first outer connection section has a second cutout aligned with the first bush. The load connection element has a first holding element disposed near the first cutout, the holding element engaging in a groove in the housing wall which runs perpendicular to the X direction.

Abstract: A method is described for producing an engine component, more particularly a piston for an internal combustion engine, in which an aluminium alloy is cast using the gravity die casting method and wherein the aluminium alloy comprises the following alloy elements: 9 to ?10.5% by weight silicon, >2.0 to <3.5% by weight nickel, >3.7 to 5.2% by weight copper, <1% by weight cobalt, 0.5 to 1.5% by weight magnesium, 0.1 to 0.7% by weight iron, 0.1 to 0.4% by weight manganese, >0.1 to <0.2% by weight zirconium, >0.1 to <0.2% by weight vanadium, 0.05 to <0.2% by weight titanium, 0.004 to 0.008% by weight phosphorus, wherein said aluminium alloy further comprises aluminium and unavoidable impurities.

Abstract: A method for producing an engine component, more particularly a piston for an internal combustion engine, in which an aluminium alloy is cast using the gravity die casting method is provided. The aluminium alloy comprises: 9 to ?10.5% by weight silicon, >2.0 to <3.5% by weight nickel, >3.7 to 5.2% by weight copper, <1% by weight cobalt, 0.5 to 1.5% by weight magnesium, 0.1 to 0.7% by weight iron, 0.1 to 0.4% by weight manganese, >0.1 to <0.2% by weight zirconium, >0.1 to <0.2% by weight vanadium, 0.05 to <0.2% by weight titanium, 0.004 to 0.008% by weight phosphorus, with aluminium and unavoidable impurities constituting the rest. An engine component, in particular a piston, wherein the engine component consists, at least partially, of the aluminium alloy, and the use of an aluminium alloy to produce the engine component, is also provided.

Abstract: A piston including at least one insert disposed between an inner surface of a ring belt and undercrown surface, and/or between the inner surface of the ring belt and a pin boss, to provide reinforcement to the ring belt is provided. The insert reduces thermal and mechanical distortion of the ring belt, and thus increases the piston ring performance, reduces blow-by, and ultimately improves engine emissions. The insert is formed by an additive machining process, such as direct depositing, laser cladding, laser sintering, arc welding, additive welding, plasma transferred arc spraying, plasma welding, arc welding, selective laser sintering, and high velocity oxygen fuel spraying, plasma spraying. According to one embodiment, an intermediate piece is mechanically attached to the piston, and the insert is applied to the intermediate piece, to provide additional reinforcement.

Abstract: The invention relates to a method for producing an engine component, in particular a piston for an internal combustion engine, wherein an aluminum alloy is cast in the gravity die casting process and wherein the aluminum alloy has 7 to <14.5 wt % silicon, >1.2 to ?4 wt % nickel, >3.7 to <10 wt % copper, <1 wt % cobalt, 0.1 to 1.5 wt % magnesium, 0.1 to ?0.7 wt % iron, 0.1 to ?0.7 wt % manganese, >0.1 to <0.5 wt % zirconium, ?0.1 to ?0.3 wt % vanadium, 0.05 to 0.5 wt % titanium, and 0.004 to ?0.05 wt % phosphorus as alloying elements and aluminum and unavoidable contaminants as the remainder. The aluminum alloy can optionally comprise beryllium, wherein the calcium content is limited to a low level.

Abstract: A power semiconductor device comprises a substrate; and power semiconductor components disposed on and connected thereto. The device includes a housing part with a housing wall having a first cutout. The device has, for making electrical contact therewith, a unitary load connection element which passes through the first cutout in an X direction, is electrically conductive, and has an outer connection section disposed outside the housing part and an inner connection section disposed within the housing part. A first bush which has an internal thread running in the X direction is rotationally fixed and movable in the X direction in the housing wall. The first outer connection section has a second cutout aligned with the first bush. The load connection element has a first holding element disposed near the first cutout, the holding element engaging in a groove in the housing wall which runs perpendicular to the X direction.

Abstract: A method is described for producing an engine component, more particularly a piston for an internal combustion engine, in which an aluminium alloy is cast using the gravity die casting method and wherein the aluminium alloy comprises the following alloy elements: 9 to ?10.5% by weight silicon, >2.0 to <3.5% by weight nickel, >3.7 to 5.2% by weight copper, <1% by weight cobalt, 0.5 to 1.5% by weight magnesium, 0.1 to 0.7% by weight iron, 0.1 to 0.4% by weight manganese, >0.1 to <0.2% by weight zirconium, >0.1 to <0.2% by weight vanadium, 0.05 to <0.2% by weight titanium, 0.004 to 0.008% by weight phosphorus, wherein said aluminium alloy further comprises aluminium and unavoidable impurities.

Abstract: A power semiconductor circuit comprising a power semiconductor switch having a control terminal and a first and a second load current terminal, and comprising a drive circuit. The power semiconductor circuit further comprises at least one of three further elements: a temperature-dependent control terminal resistance element which is electrically connected between the drive circuit and the control terminal; and/or a temperature-dependent load current terminal resistance element which is electrically connected between the drive circuit and the second load current terminal; and/or a first current branch which electrically connects the control terminal is to the second load current terminal, wherein a temperature-dependent control load current terminal resistance element is electrically connected into the first current branch. In the event of heating of a power semiconductor switch, the invention reduces the switching losses of the power semiconductor switch.

Abstract: A solar module has a solar cell which generates a DC voltage. The module has a converter for converting a DC voltage fed into its input. The module contains a semiconductor switch and a controller which drives a switching input of the semiconductor switch. The controller drives the semiconductor switch variably so that the semiconductor switch switches more slowly during the transition operation than during normal operation, thereby reducing a dynamic overvoltage on the switch such that the voltage present on the switch does not exceed the blocking voltage of the switch.