Patents by Inventor Rainer Ziermann

Rainer Ziermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20110229906
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: July 21, 2010
    Publication date: September 22, 2011
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7732186
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 8, 2010
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Recombinant Methods and Materials for Producing Epothilone and Epothilone Derivatives
    Publication number: 20090170172
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 2, 2009
    Applicant: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7402421
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: July 22, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20080044810
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: February 8, 2007
    Publication date: February 21, 2008
    Inventors: Neil Parkin, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Patent number: 7186506
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: March 6, 2007
    Assignee: Monogram Biosciences, Inc.
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Patent number: 7138231
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: November 21, 2006
    Assignee: Monogram Biosciences, Inc.
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7129071
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 31, 2006
    Assignee: KOSAN Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Production of polyketides in bacteria and yeast
    Patent number: 7078233
    Abstract: Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: July 18, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Philip J. Barr, Daniel V. Santi, Gary W. Ashley, Rainer Ziermann
  • Production of polyketides in bacteria and yeast
    Publication number: 20060148052
    Abstract: Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.
    Type: Application
    Filed: October 27, 2005
    Publication date: July 6, 2006
    Applicant: Kosan Biosciences, Inc.
    Inventors: Philip Barr, Daniel Santi, Gary Ashley, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20060035249
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: May 27, 2005
    Publication date: February 16, 2006
    Inventors: Neil Parkin, Rainer Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 6921650
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: July 26, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Patent number: 6869759
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: March 22, 2005
    Assignee: ViroLogic, Inc.
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 6858411
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 22, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Publication number: 20040253697
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Application
    Filed: May 18, 2004
    Publication date: December 16, 2004
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • 14-methyl epothilone derivatives
    Patent number: 6583290
    Abstract: Compounds of the invention include 14-mehtyl epothilone derivatives. More generally, preferred compounds of the invention are those that can be produced by altering the epothilone PKS genes as described herein and optionally by action of epothilone modification enzymes and/or by chemically modifying the resulting epothilones produces when those genes are expressed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 24, 2003
    Assignee: Kosam Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20030108857
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: June 4, 2001
    Publication date: June 12, 2003
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Production of polyketides in bacteria and yeast
    Publication number: 20020142400
    Abstract: Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.
    Type: Application
    Filed: May 8, 2001
    Publication date: October 3, 2002
    Inventors: Philip J. Barr, Daniel V. Santi, Gary W. Ashley, Rainer Ziermann
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20020064838
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: January 19, 2001
    Publication date: May 30, 2002
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • Sorangium polyketide synthases and encoding DNA therefor
    Patent number: 6280999
    Abstract: Novel Sorangium polyketide synthases, and domains thereof, and polynucleotides encoding therefor. Additionally, chimeric polyketide synthases that include domains, or subsets of domains, patterned on said novel polyketide synthases. Methods to prepare polyketide combinatorial libraries are described, as are recombinant host cells in which polyketides are produced.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: August 28, 2001
    Assignee: Kosan Bioscience
    Inventors: Claes Gustafsson, Mary C. Betlach, Gary Ashley, Bryan Julien, Rainer Ziermann