Patents by Inventor Rainer Zocher

Rainer Zocher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Patent number: 6916641
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: July 12, 2005
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf
  • Novel (r)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Publication number: 20030186410
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Application
    Filed: November 7, 2002
    Publication date: October 2, 2003
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf
  • Method for the production of baccatin-III by enzymatic synthesis
    Patent number: 6458568
    Abstract: A method for the continuous synthesis of baccatin-III is performed by means of the enzymatic acetylations of 10-deacetyl baccatin-III (10-DAB) in an enzyme reactor. This objective is accomplished by a method, for which an aqueous reaction batch is used, which contains a partially purified or a very pure acetyl transferase from a Taxus species and synthesis components, especially 10-DAB, acetyl compounds or optionally an acetyl coenzyme A, which can be regenerated, a protective colloid and optionally a buffer substance in solution. The solution is separated by a semipermeable membrane from an organic solvent, which serves as extraction agent for baccatin-III, the reaction batch being regenerated at regular intervals in an aqueous buffer system and the solvent continuously being exchanged. By conducting the reaction, the product can be removed continuously from the reaction batch for the partial synthesis of taxol and taxoter. By the above method, achievable yields are increased significantly.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: October 1, 2002
    Assignee: Institut fuer Bioanalytik, Umwelt-Toxikologie und Biotechnologie Halle GmbH
    Inventors: Konrad Glund, Matthias Hoffmann, Wolfram Weckwerth, Rainer Zocher
  • Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms
    Patent number: 6033879
    Abstract: The present invention relates to a new process for the preparation of substituted aryllactic acid-containing cyclodepsipeptides having 24 ring atoms of the formula (I): ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 have the meaning given in the description,with the aid of fungal strains of the species Agonomycetales or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: March 7, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Gerhard Bonse, Gerhard Thielking, Winfried Etzel, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher, Katsuharu Iinuma, Kouichi Miyamoto
  • Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation
    Patent number: 5945316
    Abstract: The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: August 31, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher
  • Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation
    Patent number: 5656464
    Abstract: The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: August 12, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher