Patents by Inventor Raj Chakrabarti

Raj Chakrabarti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sirtuin modulating compounds and applications thereof
    Patent number: 12215069
    Abstract: In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.
    Type: Grant
    Filed: January 24, 2024
    Date of Patent: February 4, 2025
    Assignee: CODAGEN BIOSCIENCES, INC.
    Inventors: Célina Reverdy, Gaetan Gitton, Xiangying Guan, Indranil Adhya, Rama Krishna Dumpati, Samir Roy, Santu Chall, Anisha Ghosh, Gauthier Errasti, Thomas Delacroix, Raj Chakrabarti
  • SIRTUIN MODULATING COMPOUNDS AND APPLICATIONS THEREOF
    Publication number: 20240228432
    Abstract: In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.
    Type: Application
    Filed: January 24, 2024
    Publication date: July 11, 2024
    Inventors: Célina REVERDY, Gaetan GITTON, Xiangying GUAN, Indranil ADHYA, Rama Krishna DUMPATI, Samir ROY, Santu CHALL, Anisha GHOSH, Gauthier ERRASTI, Thomas DELACROIX, Raj CHAKRABARTI
  • SIRTUIN MODULATING COMPOUNDS AND APPLICATIONS THEREOF
    Publication number: 20240228431
    Abstract: In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.
    Type: Application
    Filed: December 29, 2022
    Publication date: July 11, 2024
    Inventors: Célina Reverdy, Gaetan Gitton, Xiangying Guan, Indranil Adhya, Rama Krishna Dumpati, Samir Roy, Santu Chall, Anisha Ghosh, Gauthier Errasti, Thomas Delacroix, Raj Chakrabarti
  • Sirtuin modulating compounds and applications thereof
    Patent number: 12012370
    Abstract: In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.
    Type: Grant
    Filed: December 29, 2022
    Date of Patent: June 18, 2024
    Assignee: CODAGEN BIOSCIENCES, INC.
    Inventors: Célina Reverdy, Gaetan Gitton, Xiangying Guan, Indranil Adhya, Rama Krishna Dumpati, Samir Roy, Santu Chall, Anisha Ghosh, Gauthier Errasti, Thomas Delacroix, Raj Chakrabarti
  • System for determination of temperature cycling protocols for polymerase chain reactions; oligonucleotide annealing
    Patent number: 11915794
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 27, 2024
    Assignee: Chakrabarti Advanced Technology LLC
    Inventor: Raj Chakrabarti
  • COMPOSITIONS AND METHODS FOR SILENCING KRAS
    Publication number: 20240060069
    Abstract: The invention relates to the inhibition of mutant KRAS sequences using RNA interference (RNAi). In addition, the present invention provides lipid nanoparticle (LNP) compositions as delivery vehicles for RNAi agents and methods of administering them for therapeutic purposes.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 22, 2024
    Inventors: Raj CHAKRABARTI, Robert J. LEE, Thomas DELACROIX, Gauthier ERRASTI, Coralie LEBLEU, Anisha GHOSH, Ioanna PETROUNIA
  • System for determination of temperature cycling protocols for polymerase chain reactions:plymerase extension
    Patent number: 11854667
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: December 26, 2023
    Assignee: Chakrabarti Advanced Technology LLC
    Inventor: Raj Chakrabarti
  • System for determination of temperature cycling protocols for polymerase chain reactions: DNA melting
    Patent number: 11817178
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 14, 2023
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY LLC
    Inventor: Raj Chakrabarti
  • System for determination of temperature cycling protocols for polymerase chain reactions: optimally controlled PCR
    Patent number: 11810647
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 7, 2023
    Assignee: Chakrabarti Advanced Technology LLC
    Inventor: Raj Chakrabarti
  • Methods for the design of mechanism-based sirtuin activating compounds
    Patent number: 11459597
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: October 4, 2022
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY LLC
    Inventors: Raj Chakrabarti, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • METHODS FOR THE DESIGN OF NONALLOSTERIC SIRTUIN ACTIVATING COMPOUNDS
    Publication number: 20220002778
    Abstract: The present invention provides workflows for the discovery of nonallosteric sirtuin activation compounds. Workflows enable drug discovery of novel sirtuin activating compounds with prescribed effects on the binding in pockets near the active site interacting with flexible protein degrees of freedom around the active site. Novel kinetic models are used to confirm hit compounds and to improve their properties.
    Type: Application
    Filed: June 23, 2021
    Publication date: January 6, 2022
    Inventors: Raj Chakrabarti, Xiangying Guan, Alok Upadhyay
  • Methods for the design of mechanism-based sirtuin activating compounds
    Patent number: 11118211
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: September 14, 2021
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY LLC
    Inventors: Raj Chakrabarti, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • System and methods for determination of temperature cycling protocols for polymerase chain reactions
    Patent number: 10861586
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: December 8, 2020
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY, LLC
    Inventor: Raj Chakrabarti
  • METHODS FOR THE DESIGN OF MECHANISM-BASED SIRTUIN ACTIVATING COMPOUNDS
    Publication number: 20200370089
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Application
    Filed: August 6, 2020
    Publication date: November 26, 2020
    Inventors: Raj CHAKRABARTI, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • SYSTEM FOR DETERMINATION OF TEMPERATURE CYCLING PROTOCOLS FOR POLYMERASE CHAIN REACTIONS: DNA MELTING
    Publication number: 20190295686
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Application
    Filed: February 20, 2019
    Publication date: September 26, 2019
    Inventor: Raj CHAKRABARTI
  • SYSTEM FOR DETERMINATION OF TEMPERATURE CYCLING PROTOCOLS FOR POLYMERASE CHAIN REACTIONS:PLYMERASE EXTENSION
    Publication number: 20190279739
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Application
    Filed: February 20, 2019
    Publication date: September 12, 2019
    Inventor: Raj CHAKRABARTI
  • SYSTEM FOR DETERMINATION OF TEMPERATURE CYCLING PROTOCOLS FOR POLYMERASE CHAIN REACTIONS; OLIGONUCLEOTIDE ANNEALING
    Publication number: 20190189245
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 20, 2019
    Inventor: Raj CHAKRABARTI
  • SYSTEM FOR DETERMINATION OF TEMPERATURE CYCLING PROTOCOLS FOR POLYMERASE CHAIN REACTIONS: OPTIMALLY CONTROLLED PCR
    Publication number: 20190189244
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 20, 2019
    Inventor: Raj CHAKRABARTI
  • METHODS FOR THE DESIGN OF MECHANISM-BASED SIRTUIN ACTIVATING COMPOUNDS
    Publication number: 20180258464
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Application
    Filed: September 14, 2016
    Publication date: September 13, 2018
    Inventors: Raj CHAKRABARTI, Alok UPADHYAY, Sudipto MUNSHI, Suyambu Kesava Vijayan RAMASWAMY, Xiangying GUAN
  • SYSTEM AND METHODS FOR DETERMINATION OF TEMPERATURE CYCLING PROTOCOLS FOR POLYMERASE CHAIN REACTIONS
    Publication number: 20160103952
    Abstract: In one aspect, methods are described herein for enhancing one or more nucleic acid interactions. For example, in some embodiments, methods of enhancing one or more steps of polymerase chain reaction (PCR) are described herein. In some embodiments, the optimal temperature cycling protocol for one or more PCR cycles can be determined according to methods described herein.
    Type: Application
    Filed: May 22, 2014
    Publication date: April 14, 2016
    Inventor: Raj CHAKRABARTI