Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans. The novel compounds have a structure according to Formula I or a pharmaceutically acceptable salt, stereoisomer or deuterated analog thereof, wherein X, R1, R2 and Y are as described herein.

Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Abstract: A system and method for search, including steps of: receiving one or more search terms; searching an index for the one or more search terms to generate search results; retrieving the search results, wherein some of the search results include web pages associated with application programs; preparing a search results page for presentation to the user, wherein said search results page comprises at least a partial listing of the search results; presenting a search tool pod located on a portion of the search results page without obscuring the search results, wherein said search tool pod includes a list of application modules for executing the application programs associated with the search results that are presented; receiving a selection of a first application module; and presenting the first application module for user interaction in an area of the search results page that is smaller than the entire search results page.

Abstract: Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.

Abstract: The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.

Abstract: A system and method for search, including steps of: receiving one or more search terms; searching an index for the one or more search terms to generate search results; retrieving the search results, wherein some of the search results include web pages associated with application programs; preparing a search results page for presentation to the user, wherein said search results page comprises at least a partial listing of the search results; presenting a search tool pod located on a portion of the search results page without obscuring the search results, wherein said search tool pod includes a list of application modules for executing the application programs associated with the search results that are presented; receiving a selection of a first application module; and presenting the first application module for user interaction in an area of the search results page that is smaller than the entire search results page.

Abstract: A method and apparatus for computing efficiency score of a page is provided and using the efficiency score to optimize page design. Eye tracking study is performed on a group of subjects where eye fixation data, gaze plot data, and qualitative information data are collected. Fixation information data for page is aggregated over the subjects in the study. The fixation information data is divided into a grid. Number of fixations is computed for every grid element. Seen and noticed thresholds are established for every grid element. Seen and noticed area of a page is computed by counting number of grid elements falling into either threshold. Ratio of area noticed over area seen is computed to yield efficiency score. Page fixation data are compared for alternate page designs. Areas of large difference are correlated with gaze plots and qualitative data to identify distinguishing features.

Abstract: A tool which allows users to define one or more event/action pairs, thereby speeding and customizing the user's interaction with web documents. Such event/action pairs may include keyboard shortcuts and associated actions, and the user can add, edit, or delete some or all such keyboard shortcuts through a convenient interface. The event/action pairs may also be associated with an account provided by a service provider, whereby the user can cause any browser that can access the service provider to load the event/action pairs, which in turn allows the user to work efficiently regardless of the computing device and/or browser available to the user.

Abstract: Systems, methods and computer program products are disclosed for assisting search request by presenting suggestion of one or more vertical segments to produce a more focused result. A vertical segment may be selected by the user, the selected vertical segment being associated with one or more query terms and a search is performed on an index associated with the vertical segment. A search engine generates a search result and returns a list of search result pages for presentation to a user.

Abstract: Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.

Abstract: The present invention is directed towards systems, methods and computer program products for assisting search request by presenting suggestion of one or more vertical segments to produce a more focused result. A vertical segment may be selected by the user, the selected vertical segment being associated with one or more query terms and a search is performed on an index associated with the vertical segment. A search engine generates a search result and returns a list of search result pages for presentation to a user.

Abstract: The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.

Abstract: The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.

Abstract: Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.

Abstract: A tool which allows users to define one or more event/action pairs, thereby speeding and customizing the user's interaction with web documents. Such event/action pairs may include keyboard shortcuts and associated actions, and the user can add, edit, or delete some or all such keyboard shortcuts through a convenient interface. The event/action pairs may also be associated with an account provided by a service provider, whereby the user can cause any browser that can access the service provider to load the event/action pairs, which in turn allows the user to work efficiently regardless of the computing device and/or browser available to the user.

Abstract: A method and apparatus for computing efficiency score of a page is provided and using the efficiency score to optimize page design. Eye tracking study is performed on a group of subjects where eye fixation data, gaze plot data, and qualitative information data are collected. Fixation information data for page is aggregated over the subjects in the study. The fixation information data is divided into a grid. Number of fixations is computed for every grid element. Seen and noticed thresholds are established for every grid element. Seen and noticed area of a page is computed by counting number of grid elements falling into either threshold. Ratio of area noticed over area seen is computed to yield efficiency score. Page fixation data are compared for alternate page designs. Areas of large difference are correlated with gaze plots and qualitative data to identify distinguishing features.

Abstract: A solution is provided wherein an identification of a user who is producing low value to a web page or service is received, wherein the identification was determined by measuring web page usage patterns for the user. Advertising is then presented on the web page or service for the user according to a retraining program, wherein the retraining program is designed to retrain the user's behavior so that the user no longer produces low value and wherein the retraining program presents advertising in a different way than would be presented without the retraining program.

Abstract: Methods and apparatus are described for aggregating and presenting information in a network. A plurality of information sources relating to a category of subject matter are identified. Each information sources represents content from an associated site on the network. Each site has at least one parameter associated therewith representative of reliability with respect to the category. The content is periodically received from each of the plurality of information sources. The content received from the information sources via the network is indexed in a database. A portion of the content from the database is presented to a user via the network. The portion of the content corresponds to an index specified by the user.