Abstract: The disclosure relates to immunotoxins, particularly immunotoxins useful for treating IL-13R?2 expressing cancer, or reducing perineural invasion by an IL-13R?2 expressing cancer. Immunotoxins that specifically bind IL-13R?2, nucleic acids encoding the immunotoxins, vectors including the nucleic acids encoding the immunotoxins, and host cells expressing the immunotoxins are provided. Also provided are pharmaceutical compositions including the immunotoxin and methods of treating a subject with cancer, including administering to the subject the immunotoxin alone or in combination with other cancer therapies. Also provided are methods of reducing perineural invasion (PNI) and reducing pain associated with PNI, by administering a therapeutically effective amount of the immunotoxin or IL-13-PE immunotoxin.

Abstract: Immunotherapies, particularly chimeric antigen receptors targeting IL-13R?2 and their use for treating cancer are provided. A single chain fragment variable (scFv) that specifically binds IL-13R?2, chimeric antigen receptors (CARs) including the IL-13R?2 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Also provided are methods of treating a subject with cancer, including administering to the subject an immune cell expressing an IL-13R?2 scFv-CAR alone or in combination with other cancer therapies.

Abstract: The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 or interleukin-13 protein moiety joined to an anti-apoptotic Bcl-2 family member protein moiety.

Abstract: The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 or interleukin-13 protein moiety joined to an anti-apoptotic Bcl-2 family member protein moiety.

Abstract: The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 receptor binding protein moiety joined to a pro-apoptotic Bcl-2 family member protein moiety.

Abstract: The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 receptor binding protein moiety joined to a pro-apoptotic Bcl-2 family member protein moiety.

Abstract: Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFN?), and an interferon gamma (IFN?). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.

Abstract: Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFN?), and an interferon gamma (IFN?). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.

Abstract: The present disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or derivatives thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.

Abstract: The present disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or derivatives thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.

Abstract: Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.

Abstract: The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2 responses to TH1 responses by administering IL-13 receptor-targeted immunotoxins to the respiratory tract.

Abstract: The invention relates to the discovery that cancer cells that have no or low expression of the IL-13 receptor (“IL-13R”) can bind IL-13R-targeted immunoconjugates, such as immunotoxins, by transfection with the IL-13R&agr;2 chain alone. Transfecting cells with just the IL-13R&agr;2 chain is easier than transfection with an intact receptor. For some cancers, transfection with the IL-13R&agr;2 chain alone inhibits tumor growth. Those cancers that are not inhibited by the presence of the IL-13R&agr;2 chain alone, and which do not express the IL-13R or express it only at low levels can be rendered sensitive to IL-13R-targeted immunoconjugates by transfection of the IL-13&agr;2 chain and can be inhibited by the use of immunoconjugates, such as immunotoxins, targeted to the IL-13R.

Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell. The method involves providing a chimeric molecule that comprises an effector molecule attached to a targeting molecule that specifically binds an IL-13 receptor and contacting a tumor cell with the chimeric molecule.

Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell bearing an IL-13 receptor. The method involves providing a chimeric molecule that comprises an effector molecule attached to a circularly permuted IL-13 (“cpIL-13”) that specifically binds an IL-13 receptor and contacting the tumor cell with the chimeric molecule. The compositions include chimeric molecules comprising effector molecules such as modified Pseudomonas exotoxin attached to a cpIL-13. The invention further provides vectors encoding the chimeric molecules.