Abstract: Automated multi-layer two-dimensional printing is provided via a plurality of supply tanks; a deposition tank; a plurality of pumps each comprising: a pipeline in fluid communication with one supply tank and the deposition tank on opposing ends; a bearing holder, including a plurality of rotatable bearings arranged at a shared angle to each other relative to an axis of rotation for the bearing holder; a housing wall, wherein at least a subset of the plurality of rotatable bearings compresses the pipeline against the housing wall; and a motor configured to rotate the bearing holder about the axis of rotation and push a fluid through the pipeline by moving the plurality of rotatable bearings about the axis of rotation to change where the rotatable bearings compress the pipeline against the housing wall; and a spray deposition nozzle in fluid communication with the deposition tank.

Abstract: The invention relates to a new microorganism Streptomyces glaucescens MTCC 5115 and a process for producing the immunosuppressant agent, tacrolimus (FK-506) utilizing the new microorganism Streptomyces glaucescens MTCC 5115. The invention also relates to pharmaceutical compositions that include the tacrolimus (FK-506) and use of said compositions for treatment or prevention of the transplantation rejection of organs or tissues such as heart, kidney, liver, medulla ossium, skin, etc.