Abstract: Provided herein are methods and compositions useful for the treatment of neurodegenerative diseases that include adeno-associated viral vectors that encode one or more peptides that inhibit ?-synuclein aggregation. Such peptides are useful for treating neurodegenerative diseases such as Alzheimer's disease, a Lewy body disorder, Parkinson's disease (PD), PD with dementia (PDD), pure autonomic failure (PAF), and multiple system atrophy (MSA).

Abstract: The present disclosure relates to compositions comprising racemic ketamine, or a pharmaceutically acceptable salt thereof, for use in treating psychiatric disorders such as suicidality, suicidal ideation, major depressive disorder, treatment-resistant depression, and post-traumatic stress disorder.

Abstract: The present disclosure relates to compositions comprising racemic ketamine, or a pharmaceutically acceptable salt thereof, for use in treating psychiatric disorders such as suicidality, suicidal ideation, major depressive disorder, treatment-resistant depression, and post-traumatic stress disorder.

Abstract: The present disclosure relates to compositions comprising racemic ketamine, or a pharmaceutically acceptable salt thereof, for use in treating psychiatric disorders such as suicidality, suicidal ideation, major depressive disorder, treatment-resistant depression, and post-traumatic stress disorder.

Abstract: The present disclosure relates to compositions comprising racemic ketamine, or a pharmaceutically acceptable salt thereof, for use in treating psychiatric disorders such as suicidality, suicidal ideation, major depressive disorder, treatment-resistant depression, and post-traumatic stress disorder.

Abstract: The present disclosure relates to methods of treating or alleviating one or more symptoms of mucopolysaccharidoses in a subject, via administering a trehalose formulation to the subject.

Abstract: An example method includes presenting, by a computing device, via a user interface (UI), a representation of the medical device and respective representations of one or more components that are attachable to the medical device, wherein the one or more components comprise at least one of leads, adaptors, extensions, or catheters, receiving, by the computing device, via the UI, an indication of a selected component included in the component(s) for attachment to the medical device, and responsive to receiving the indication of the selected component: indicating, by the computing device and via the UI, attachment of the representation of the selected component to the representation of the medical device, and updating, by the computing device, the presentation of the respective representations of the component(s) via the UI to include representations of one or more components that are attachable to the medical device with the selected component.

Abstract: Devices, systems, and techniques for adjusting posture state definitions used to determine a posture state of a patient are described. In one example, a system may include an external programmer that includes a user interface configured to present an indication of a first posture state determined from the data representative of the patient posture during the period of time and a set of posture state definitions that at least partially define a plurality of posture states. The external programmer may also include a processor configured to receive an adjustment input from a user that requests an adjustment to the set of posture state definitions and obtain a second posture state, the second posture state determined from the data representative of the patient posture during the period of time and the adjusted set of posture state definitions. The user interface presents an indication of the second posture state.

Abstract: An example method includes presenting, by a computing device, a range of available parameter values for the therapy parameter via a circular track, indicating, by the computing device, a present parameter value for the therapy parameter via the circular track, and receiving, by the computing device, via a user interface (UI), user input specifying a target parameter value for the therapy parameter, indicating, by the computing device, the target parameter value in conjunction with the present parameter value via the circular track, receiving by the computing device, via the UI, user input activating an adjustment from the present parameter value to the target parameter value, and in response to receiving the user input activating the adjustment, controlling, by the computing device, the medical device to adjust the therapy parameter value from the present parameter value to the target parameter value.

Abstract: Devices, systems, and techniques for adjusting posture state definitions used to determine a posture state of a patient are described. In one example, a system may include an external programmer that includes a user interface configured to present an indication of a first posture state determined from the data representative of the patient posture during the period of time and a set of posture state definitions that at least partially define a plurality of posture states. The external programmer may also include a processor configured to receive an adjustment input from a user that requests an adjustment to the set of posture state definitions and obtain a second posture state, the second posture state determined from the data representative of the patient posture during the period of time and the adjusted set of posture state definitions. The user interface presents an indication of the second posture state.

Abstract: An example method includes presenting, by a computing device, a range of available parameter values for the therapy parameter via a circular track, indicating, by the computing device, a present parameter value for the therapy parameter via the circular track, and receiving, by the computing device, via a user interface (UI), user input specifying a target parameter value for the therapy parameter, indicating, by the computing device, the target parameter value in conjunction with the present parameter value via the circular track, receiving by the computing device, via the UI, user input activating an adjustment from the present parameter value to the target parameter value, and in response to receiving the user input activating the adjustment, controlling, by the computing device, the medical device to adjust the therapy parameter value from the present parameter value to the target parameter value.

Abstract: An example method includes presenting, by a computing device, via a user interface (UI), a representation of the medical device and respective representations of one or more components that are attachable to the medical device, wherein the one or more components comprise at least one of leads, adaptors, extensions, or catheters, receiving, by the computing device, via the UI, an indication of a selected component included in the component(s) for attachment to the medical device, and responsive to receiving the indication of the selected component: indicating, by the computing device and via the UI, attachment of the representation of the selected component to the representation of the medical device, and updating, by the computing device, the presentation of the respective representations of the component(s) via the UI to include representations of one or more components that are attachable to the medical device with the selected component.

Abstract: An intermediate hydrogen separation and absorption-based purification system is integrated with a hydrocracking process for the production of relatively lower molecular weight products from a relatively heavy feedstock including sulfur-containing and nitrogen-containing hydrocarbon compounds. The integrated process allows the processing of heavy hydrocarbon feedstock having high nitrogen and high sulfur contents in a single-stage configuration and the using of noble metal catalyst in the hydrocracking reaction zone. The integrated process increases the overall catalytic activity and hydrogenation capability to produce superior distillate products.

Abstract: An intermediate hydrogen separation and purification system is integrated with a hydrotreating and an aromatic saturation process for the production of relatively lower molecular weight products from a relatively heavy feedstock including sulfur-containing and aromatic-containing hydrocarbon compounds. The integrated process allows the processing of heavy hydrocarbon feedstock having high aromatic and high sulfur contents in a single-stage configuration and the using of noble metal catalyst in the aromatic saturation zone. The integrated process increases the overall catalytic activity and hydrogenation capability to produce superior distillate products.

Abstract: An intermediate hydrogen separation and purification system is integrated with a hydrotreating and an aromatic saturation process for the production of relatively lower molecular weight products from a relatively heavy feedstock including sulfur-containing and aromatic-containing hydrocarbon compounds. The integrated process allows the processing of heavy hydrocarbon feedstock having high aromatic and high sulfur contents in a single-stage configuration and the using of noble metal catalyst in the aromatic saturation zone. The integrated process increases the overall catalytic activity and hydrogenation capability to produce superior distillate products.

Abstract: In a hydrocracking unit, the flash gases from the high-pressure separator are fed to the bottom of an absorption zone where the entering gases are counter-currently contacted with a lean solvent. The lean solvent absorbs away the contained methane, ethane, propane, butanes and pentanes (C1+) from the contained hydrogen. The overhead gas stream from the absorption zone typically contains hydrogen at a purity of 90 to 98 mol %, or even higher, which is fed to the recycle gas stream to provide hydrogen purity in the range of 96 to 99 mol %, thereby providing an increase in the overall efficiency of the hydroprocessor unit. The process can also be employed with hydrotreating, hydrodesulfurization, hydrodenitrogenation and hydrodealkylation reactors.

Abstract: In a hydrocracking unit, the flash gases from the high-pressure separator are fed to the bottom of an absorption zone where the entering gases are counter-currently contacted with a lean solvent. The lean solvent absorbs away the contained methane, ethane, propane, butanes and pentanes (C1+) from the contained hydrogen. The overhead gas stream from the absorption zone typically contains hydrogen at a purity of 90 to 98 mol %, or even higher, which is fed to the recycle gas stream to provide hydrogen purity in the range of 96 to 99 mol %, thereby providing an increase in the overall efficiency of the hydroprocessor unit. The process can also be employed with hydrotreating, hydrodesulfurization, hydrodenitrogenation and hydrodealkylation reactors.