Abstract: The present invention involves nucleic acid vectors (e.g., circular DNA vectors) and compositions thereof. Also provided herein are methods of administering nucleic acid vectors (e.g., circular DNA vectors) and compositions thereof, e.g., in combination with pulsed electric field therapy.

Abstract: Disclosed is a system for analyzing and structuring data records, wherein the system comprises a server arrangement operable to: extract data records from publicly available data sources; identify a class of each of the data records; analyze one or more parameters related to each of the data records to calculate a data potency score for each of the data records, wherein the one or more parameters that are analyzed for a data record are selected based on the class of the data record; tag the data potency score with data record corresponding thereto; process the data records with corresponding tagged data potency scores into a uniform format; and store the processed data records in a database arrangement as structured data records.

Abstract: Disclosed is a system for automated document generation. The system comprises a database arrangement comprising a plurality of structured data records and a processing arrangement communicably coupled to the database arrangement. The processing arrangement receives a user input from a user relating to at least: a type of the document to be generated, information to be included in the document to be generated. Moreover, the processing arrangement analyzes user input relating to the type of document to be generated to determine related structured data records to be retrieved from the database arrangement, retrieves the related structured data records from the database arrangement, analyzes the related structured data records to determine attributes for the document to be generated and uses the determined attributes and the user input relating to the information to be included in the document to be generated to generate the document.

Abstract: Protein constructs comprising a BTNL3/8 targeting moiety, a payload and an optional linker are described herein. Pharmaceutical compositions comprising the constructs, and methods of use thereof are presented.

Abstract: Disclosed is a system for automated document generation. The system comprises a database arrangement comprising a plurality of structured data records and a processing arrangement communicably coupled to the database arrangement. The processing arrangement receives a user input from a user relating to at least: a type of the document to be generated, information to be included in the document to be generated. Moreover, the processing arrangement analyzes user input relating to the type of document to be generated to determine related structured data records to be retrieved from the database arrangement, retrieves the related structured data records from the database arrangement, analyzes the related structured data records to determine attributes for the document to be generated and uses the determined attributes and the user input relating to the information to be included in the document to be generated to generate the document.

Abstract: Disclosed is a system for analyzing and structuring data records, wherein the system comprises a server arrangement operable to: extract data records from publicly available data sources; identify a class of each of the data records; analyze one or more parameters related to each of the data records to calculate a data potency score for each of the data records, wherein the one or more parameters that are analyzed for a data record are selected based on the class of the data record; tag the data potency score with data record corresponding thereto; process the data records with corresponding tagged data potency scores into a uniform format; and store the processed data records in a database arrangement as structured data records.

Abstract: Systems and methods for automated transaction analysis are disclosed. In one embodiment, a method for transaction evaluation may include (1) a computer processor receiving an identification of a plurality of completed transactions that were completed using a first transaction account; (2) the computer processor receiving an identification of a first benefit earned based on the first transaction account; (3) the computer processor receiving a plurality of parameters for a second transaction account; (4) the computer processor simulating a usage of the second transaction account by applying the plurality of parameters for the second transaction account to the completed transactions; (5) the computer processor identifying a second benefit earned based on the simulation; and (6) the computer processor outputting the results of the simulation comprising a comparison of the first benefit to the second benefit.

Abstract: The present invention provides engineered lymphocytes (e.g., ?? T cells, NK cells, NK-like T cells, engineered innate lymphoid cells, or MAIT cells) comprising a heterologous targeting construct lacking an intracellular signaling domain capable of activating the lymphocyte on which the construct is expressed. Further provided are compositions of engineered lymphocytes (e.g., ?? T cells) and methods of using the engineered lymphocytes (e.g., ?? T cells, e.g., a part of an adoptive T cell therapy).

Abstract: The present invention provides an in vitro method for detecting cell-cell interactions and associated kits and uses, where the method comprises: (a) at least two primary binding agents, wherein the first primary binding agent binds to a first molecule on a first cell and the second primary binding agent binds to a second molecule on a second cell, and wherein the first and second primary binding agents are immunologically distinct; (b) at least two secondary binding agents, wherein a first secondary binding agent binds to the first primary binding agent; and a second secondary binding agent binds the second primary binding agent, wherein the first secondary binding agent does not bind the second primary binding agent and the second secondary binding agent does not buy the first primary binding agent; and wherein: (i) the first secondary binding agent is labelled with a FRET donor and the second secondary binding agent is labelled with a FRET acceptor; (ii) the first and second secondary binding agents are con

Abstract: The invention relates to a novel purified recombinant ?V?3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural ?V?3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the soluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length ?V?3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.

Abstract: A pillar to rocker joint assembly comprising a tubular pillar having a pinched flange near a lower end of the pillar is joined to a rocker assembly including a side sill and rocker reinforcement. A method of making a pillar to rocker joint assembly that comprises a vehicle structural support is formed by welding a structural support pillar to an outer body panel through an access opening in the pillar and welding a rocker reinforcement to a side sill. The rocker reinforcement is welded to the pillar through an access opening in the side sill, an access hole in the body outer panel, and an access opening in the pillar that is vertically spaced relative to the first access opening. A bottom flange of the B-pillar is welded to a lower edge flange of the rocker reinforcement and a lower edge flange of the side sill.

Abstract: A pillar to rocker joint assembly comprising a tubular pillar having a pinched flange near a lower end of the pillar is joined to a rocker assembly including a side sill and rocker reinforcement. A method of making a pillar to rocker joint assembly that comprises a vehicle structural support is formed by welding a structural support pillar to an outer body panel through an access opening in the pillar and welding a rocker reinforcement to a side sill. The rocker reinforcement is welded to the pillar through an access opening in the side sill, an access hole in the body outer panel, and an access opening in the pillar that is vertically spaced relative to the first access opening. A bottom flange of the B-pillar is welded to a lower edge flange of the rocker reinforcement and a lower edge flange of the side sill.

Abstract: A foaming root destroyer is provided that utilizes a combination of herbicides and bacteria to inhibit and destroy the roots and fine root hairs intruding into underground discharge waste pipe systems. Furthermore, the foaming root destroyer can work over a longer period of time providing an enzymatic process to degrade and eliminate the dead root mass in the sewer line.

Abstract: The present invention relates to aspects of drain cleaning compositions, methods, and systems involving multiple levels of attack to facilitate decomposition of clogs in pipe systems. Aspects of the invention relate to a multi-action drain cleaning composition including chemical and biological components capable of producing an exothermic reaction, an oxidation reaction, and an enzymatic reaction. Generally, the chemical components act immediately to clear a clog in a pipe system and the biological components act over a longer period of time to provide longer-term maintenance of the pipe system. Additional aspects of the invention relate to a composition for use as a component of a multi-action drain cleaner that includes bacteria selectively cultured to subsist in a peroxygen-rich environment, a high-heat environment, and/or a high-pH environment. A bio-film for reducing or preventing a buildup of organic material in a pipe system including a matrix and a selectively cultured bacteria is also provided.

Abstract: A foaming root destroyer is provided that utilizes a combination of herbicides and bacteria to inhibit and destroy the roots and fine root hairs intruding into underground discharge waste pipe systems. Furthermore, the foaming root destroyer can work over a longer period of time providing an enzymatic process to degrade and eliminate the dead root mass in the sewer line.

Abstract: A joint assembly for joining a tubular B-pillar to a tubular roof rail. The joint assembly includes an inner bracket plate and an outer bracket plate that are welded to each other around the roof rail and B-pillar. The outer bracket plate extends across the B-pillar, over the roof rail, and laterally inwardly from the roof rail to provide an attachment surface for a roof support bow.

Abstract: A pillar to rocker joint assembly comprising a tubular pillar having a pinched flange near a lower end of the pillar is joined to a rocker assembly including a side sill and rocker reinforcement. A method of making a pillar to rocker joint assembly that comprises a vehicle structural support is formed by welding a structural support pillar to an outer body panel through an access opening in the pillar and welding a rocker reinforcement to a side sill. The rocker reinforcement is welded to the pillar through an access opening in the side sill, an access hole in the body outer panel, and an access opening in the pillar that is vertically spaced relative to the first access opening. A bottom flange of the B-pillar is welded to a lower edge flange of the rocker reinforcement and a lower edge flange of the side sill.

Abstract: A one-piece B-pillar having a front flange and a rear flange formed on an upper portion of the B-pillar. The front and rear flanges extend forwardly and rearwardly from a trapezoidal section of the B-pillar. An inner concave portion is provided in a lower portion of the B-pillar. The one-piece B-pillar is secured to the outer and upper surfaces of a roof rail and to the outer surface of a rocker to provide side impact strength. The B-pillar is hydroformed in one-piece to provide superior strength for roof crush performance. The tubular portion of the B-pillar is partially collapsed to form a trapezoidal section in the upper portion of the B-pillar.

Abstract: A joint assembly for joining a tubular B-pillar to a tubular roof rail. The joint assembly includes an inner bracket plate and an outer bracket plate that are welded to each other around the roof rail and B-pillar. The outer bracket plate extends across the B-pillar, over the roof rail, and laterally inwardly from the roof rail to provide an attachment surface for a roof support bow.

Abstract: A joint assembly for joining a tubular B-pillar to a tubular roof rail. The joint assembly includes an inner bracket plate and an outer bracket plate that are welded to each other around the roof rail and B-pillar. A flange of the roof rail is received in a slot formed in an upper end of the B-pillar.