Abstract: Database systems may dynamically management concurrency levels for performing queries. A query may be received at a database system and a memory usage for the query may be predicted. A determination may be made as to whether available memory is enough to satisfy the predicted memory usage for the query. If the available memory is enough to satisfy the predicted memory usage for the query, then an increase in a concurrency level for performing queries at the database system may be made. The query may be allowed to execute concurrently with other queries according to the increased concurrency level.

Abstract: The present invention relates to an improved process for the preparation of a compound of formula (I), wherein PG1 may be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), benzylidene, methanesulfonyl (Mesyl), toluene sulfonyl (Tosyl) or acyl; its isolation as solid and use for the preparation of the compound of formula (IV), in particular the compound of formula (IV) i.e. [(1R)-3-methyl-1[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid with more than 99.95% chiral purity, as measured by HPLC.

Abstract: Methods and systems are provided for the deployment of machine learning based processes to public clouds. For example, a method for deploying a machine learning based process may include developing and training the machine learning based process to perform an activity, performing at least one of identifying and receiving an identification of a set of one or more public clouds that comply with a set of regulatory criteria used to regulate the activity, selecting a first public cloud of the set of one or more public clouds that complies with the set of regulatory criteria used to regulate the activity, and deploying the machine learning based process to the first public cloud of the set of one or more public clouds.

Abstract: The invention relates to a process for the preparation of ribociclib of formula V or its salts. The invention provides novel crystalline forms of ribociclib succinate and ribociclib trifluoroacetate. The present invention also relates to pharmaceutical compositions comprising a crystalline form of ribociclib succinate and at least a pharmaceutically acceptable carrier. It further relates to the use of such compositions in the treatment of cancer.

Abstract: The present invention relates to a process for the purification of compound of formula II, wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid and phosphoric acid; its isolation as solid and use for the preparation of carfilzomib.

Abstract: A technique includes providing, by a computer, a portal to provide a catalog describing features of a plurality of cloud services available and to be provided by otherwise unused hardware resources of a plurality of private cloud providers. The technique includes, by the computer, in response to input received through the portal selecting a given cloud service for a tenant, exposing the given cloud service to the tenant. Exposing the given cloud service to the user includes requesting a given cloud provider corresponding to the given cloud service to configure the given cloud provider to provide the given cloud service to the tenant.

Abstract: Some examples relate to collection of performance metrics from a device. In an example, performance metrics for collection from a first device may be selected. The performance metrics may be indexed by assigning an index entry to respective performance metrics on the first device. A fixed sequence of the performance metrics may be maintained on first device. The fixed sequence of the performance metrics along with the index entry assigned to the respective performance metrics may be shared with a second device. A first performance data of the respective performance metrics on first device may be determined. The first performance data of the respective performance metrics may be shared with second device. The sharing may comprise sending, to second device, the index entry and the first performance data of the respective performance metrics in an order corresponding to the fixed sequence of the performance metrics on first device.

Abstract: Some examples relate to collection of performance metrics from a device. In an example, performance metrics for collection from a first device may be selected. The performance metrics may be indexed by assigning an index entry to respective performance metrics on the first device. A fixed sequence of the performance metrics may be maintained on first device. The fixed sequence of the performance metrics along with the index entry assigned to the respective performance metrics may be shared with a second device. A first performance data of the respective performance metrics on first device may be determined. The first performance data of the respective performance metrics may be shared with second device. The sharing may comprise sending, to second device, the index entry and the first performance data of the respective performance metrics in an order corresponding to the fixed sequence of the performance metrics on first device.

Abstract: The invention relates to a process for the preparation of ribociclib of formula V or its salts. The invention provides novel crystalline forms of ribociclib succinate and ribociclib trifluoroacetate. The present invention also relates to pharmaceutical compositions comprising a crystalline form of ribociclib succinate and at least a pharmaceutically acceptable carrier. It further relates to the use of such compositions in the treatment of cancer.

Abstract: Methods and systems are provided for the deployment of machine learning based processes to public clouds. For example, a method for deploying a machine learning based process may include developing and training the machine learning based process to perform an activity, performing at least one of identifying and receiving an identification of a set of one or more public clouds that comply with a set of regulatory criteria used to regulate the activity, selecting a first public cloud of the set of one or more public clouds that complies with the set of regulatory criteria used to regulate the activity, and deploying the machine learning based process to the first public cloud of the set of one or more public clouds.

Abstract: A technique includes providing, by a computer, a portal to provide a catalog describing features of a plurality of cloud services available and to be provided by otherwise unused hardware resources of a plurality of private cloud providers. The technique includes, by the computer, in response to input received through the portal selecting a given cloud service for a tenant, exposing the given cloud service to the tenant. Exposing the given cloud service to the user includes requesting a given cloud provider corresponding to the given cloud service to configure the given cloud provider to provide the given cloud service to the tenant.

Abstract: The present invention relates to an improved process for the preparation of a compound of formula (I), wherein PG1 may be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), benzylidene, methanesulfonyl (Mesyl), toluene sulfonyl (Tosyl) or acyl; its isolation as solid and use for the preparation of the compound of formula (IV), in particular the compound of formula (IV) i.e. [(1R)-3-methyl-1[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid with more than 99.95% chiral purity, as measured by HPLC.

Abstract: The present invention relates to a process for the purification of compound of formula II, wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid and phosphoric acid; its isolation as solid and use for the preparation of carfilzomib.

Abstract: The present invention relates to a process for the purification of Carfilzomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt %.

Abstract: The present invention relates to a process for the purification of Carfiizomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt %. Formula I Formula II.

Abstract: A computer executed method of determining compatible versions of dependent entities of a root entity having a specified version in a computer system. The method comprises building a directed graph containing dependent entities and dividing the directed graph into multiple levels. Compatible versions are determined for entities in upper levels of the directed graph before determining compatible versions for entities in lower levels of the directed graph.

Abstract: Adaptive power management within media delivery system. Power management is performed for one or more devices within a media or signal delivery system. Depending upon one or more local and/or remote considerations associated with one or more of the devices within the system, various processing operations may undergo appropriate provisioning among the respective devices. Considering devices that are battery-powered, certain processing operations that may be highly power or energy consumptive may be offloaded to other devices having sufficient power or energy to effectuate such operations or that are not so limited or constrained by power energy (e.g., being wall powered or non-battery-powered). Operation of one or more of the devices in compliance with a power or energy constraint may be directed by a power management application resident on one or more of the devices within the system.

Abstract: A method of delivering targeted on-line advertising to an end user of a computer network system comprises creating an advertisement campaign having a plurality of dimensions associated therewith, obtaining end user data based upon engagement of the end user with the network system, profiling advertisement content available on the network system to identify specific items of advertisement content that are compatible with the advertising campaign, for each item of compatible advertisement content, utilizing the end user data and metrics associated with the plurality of dimensions associated with the advertisement campaign to develop an effectiveness measurement, and utilizing the effectiveness measurements to select at least one item of compatible advertisement content for display to the end user.

Abstract: A method of delivering targeted on-line advertising to an end user of a computer network system comprises creating an advertisement campaign having a plurality of dimensions associated therewith, obtaining end user data based upon engagement of the end user with the network system, profiling advertisement content available on the network system to identify specific items of advertisement content that are compatible with the advertising campaign, for each item of compatible advertisement content, utilizing the end user data and metrics associated with the plurality of dimensions associated with the advertisement campaign to develop an effectiveness measurement, and utilizing the effectiveness measurements to select at least one item of compatible advertisement content for display to the end user.

Abstract: A computer executed method of determining compatible versions of dependent entities of a root entity having a specified version in a computer system. The method comprises building a directed graph containing dependent entities and dividing the directed graph into multiple levels. Compatible versions are determined for entities in upper levels of the directed graph before determining compatible versions for entities in lower levels of the directed graph.