Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: The application describes methods and compositions comprising ceDNA vectors useful for the expression of antigens and immunogenic peptides in a cell, tissue or subject, and methods of treatment and/or prevention of various infectious diseases, autoimmune disorders and cancers.

Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: This disclosure relates to mRNA therapy for the treatment of hyperphenylalaninemias such as phenylketonuria (PKU). mRNAs for use in the invention, when administered in vivo, encode human phenylalanine hydroxylase (PAH), functional fragments thereof (e.g., those comprising the catalytic domain or the catalytic domain and the tetramerization domains), and fusion proteins comprising PAH. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PAH expression and/or activity in subjects. mRNA therapies of the invention further decrease abnormal accumulation of phenylalanine associated with deficient PAH activity in subjects.

Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: The device comprises of a housing defining a channel there through, a torsion-spring based clamping mechanism, a drop sensor connected with circuitry, a manual infusion fluid regulation mechanism and a power source. An upper portion of the channel accommodates at least a part of a drip chamber and a lower portion of the channel accommodates at least a part of infusion tubing. The clamping mechanism comprises of one or more torsion springs and is configured for engaging and holding drip chamber and can be adjusted according to the drip chamber diameter. The drop sensor and the circuits coupled with it are configured for detecting real time drop rate of the infusion fluid. The regulation mechanism comprises of a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing.

Abstract: Provided herein are methods and constructs related to minimizing immune responses using inhibitors of the immune response, in particular the innate immune response, when administering a desired transgene in a cell achieved by delivery of the transgene with repeated doses of a ceDNA vector.

Abstract: Embodiments herein disclose a method for MBS switching and continuity in a 5G wireless network. The method includes establishing, by a gNodeB, a MBS session with a UE. Further, the method includes providing, by the gNodeB, MBS to the UE during the MBS session. Further, the method includes detecting, by the gNodeB, that the at least one MBS is going to get suspended or deactivated. Further, the method includes sending, by the gNodeB, an indication to the UE indicating the at least one MBS going to get suspended or deactivated prior to suspension or deactivation of the at least one MBS at the UE.

Abstract: The device comprises of a housing defining a channel there through, a torsion-spring based clamping mechanism, a drop sensor connected with circuitry, a manual infusion fluid regulation mechanism and a power source. An upper portion of the channel accommodates at least a part of a drip chamber and a lower portion of the channel accommodates at least a part of infusion tubing. The clamping mechanism comprises of one or more torsion springs and is configured for engaging and holding drip chamber and can be adjusted according to the drip chamber diameter. The drop sensor and the circuits coupled with it are configured for detecting real time drop rate of the infusion fluid. The regulation mechanism comprises of a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing.

Abstract: This disclosure relates to mRNA therapy for the treatment of hyperphenylalaninemias such as phenylketonuria (PKU). mRNAs for use in the invention, when administered in vivo, encode human phenylalanine hydroxylase (PAH), functional fragments thereof (e.g., those comprising the catalytic domain or the catalytic domain and the tetramerization domains), and fusion proteins comprising PAH. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PAH expression and/or activity in subjects. mRNA therapies of the invention further decrease abnormal accumulation of phenylalanine associated with deficient PAH activity in subjects.

Abstract: The invention relates to mRNA therapy for the treatment of Hemophilia A. mRNAs for use in the invention, when administered in vivo, encode Factor VIII, isoforms thereof, functional fragments thereof, and fusion proteins comprising Factor VIII. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of Factor VIII expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient Factor VII I activity in subjects.

Abstract: Some example embodiments disclose methods for improving Paging Type2 performance in Dual Sim Dual Standby (DSDS) devices, wherein the methods include transmitting a status Packet Data Unit (PDU) for a Signaling Radio Bearer (SRB) to a network; initiating a first timer in response to the transmitting the status PDU; blocking a radio frequency tune away to a first Subscriber Identity Module (SIM) if one or more missing PDUs are not received before expiry of the first timer; initiating a second timer in response to the blocking the RF tune away; and retaining, by a second SIM, radio frequency resources until expiry of the second timer or the one or more missing PDUs are received from the network.

Abstract: Some example embodiments disclose methods for improving Paging Type2 performance in Dual Sim Dual Standby (DSDS) devices, wherein the methods include transmitting a status Packet Data Unit (PDU) for a Signaling Radio Bearer (SRB) to a network; initiating a first timer in response to the transmitting the status PDU; blocking a radio frequency tune away to a first Subscriber Identity Module (SIM) if one or more missing PDUs are not received before expiry of the first timer; initiating a second timer in response to the blocking the RF tune away; and retaining, by a second SIM, radio frequency resources until expiry of the second timer or the one or more missing PDUs are received from the network.

Abstract: Systems and methods are provided for batch processing of data records in an on-demand system. A marker is stored that identifies a node in an on-demand system and identifies a most recent data record processed in a relational database management system by the node. The marker is used to query the database management system to identify a batch of records for the node to process. The batch of records is processed by the node to update a client of data changes reflected by the batch of records.

Abstract: According to one aspect of the invention, a turbine assembly includes a rotor wheel and a circumferential slot formed in the rotor wheel, the circumferential slot including a uniform cross-section shape for a circumference of the rotor wheel. The assembly also includes a first ring member positioned in the circumferential slot, the first ring member being configured to prevent radial movement of a dovetail attachment when positioned in the circumferential slot, wherein the dovetail attachment is part of a turbine blade.

Abstract: Systems and methods are provided for batch processing of data records in an on-demand system. A marker is stored that identifies a node in an on-demand system and identifies a most recent data record processed in a relational database management system by the node. The marker is used to query the database management system to identify a batch of records for the node to process. The batch of records is processed by the node to update a client of data changes reflected by the batch of records.

Abstract: According to one aspect of the invention, a turbine assembly includes a rotor wheel and a circumferential slot formed in the rotor wheel, the circumferential slot including a uniform cross-section shape for a circumference of the rotor wheel. The assembly also includes a first ring member positioned in the circumferential slot, the first ring member being configured to prevent radial movement of a dovetail attachment when positioned in the circumferential slot, wherein the dovetail attachment is part of a turbine blade.

Abstract: According to one embodiment of the present invention, a microwave or millimeter wave module includes a dielectric layer having a pocket formed substantially through the dielectric layer. The dielectric is attached to a metal substrate. The pocket has substantially vertical sidewalls. An integrated circuit is disposed in the pocket. Opposing sides of the integrated circuit are substantially parallel to the sidewalls of the pocket. An interconnect electrically couples the integrated circuit to a bond pad disposed on the outer surface of the dielectric layer. The interconnect has a length that is minimized to result in reduced inductance of the semiconductor device.