Patents by Inventor Raja G. Achari
Raja G. Achari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7001886Abstract: The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: GrantFiled: April 16, 2004Date of Patent: February 21, 2006Assignee: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, James R. Schleck, Vilas M. Chopdekar
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Patent number: 6939856Abstract: The invention pertains to a method for preparing dexchlorpheniramine (“dexchlor”) tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The dexchlorpheniramine free base may be obtained by reacting a commercially available dexchlorpheniramine salt such as dexchlorpheniramine maleate with a base such as aqueous sodium hydroxide. The resultant dexchlor tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: GrantFiled: August 14, 2003Date of Patent: September 6, 2005Assignee: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, Angelo R. Mellozzi, Vilas M. Chopdekar
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Publication number: 20040242625Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: April 21, 2004Publication date: December 2, 2004Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20040242624Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: April 21, 2004Publication date: December 2, 2004Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20040242626Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: April 21, 2004Publication date: December 2, 2004Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20040204441Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: April 21, 2004Publication date: October 14, 2004Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20040198667Abstract: The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydranine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: ApplicationFiled: April 16, 2004Publication date: October 7, 2004Applicant: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, James R. Schleck, Vilas M. Chopdekar
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Publication number: 20040101484Abstract: Intranasal delivery compositions and methods for the delivery of dopamine receptor agonists are provided which are effective for the treatment14 of sexual dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal, in particular adverse nasal effects. Nasally administered compositions for treating sexual dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: November 5, 2003Publication date: May 27, 2004Inventors: Charanjit R. Behl, Vincent D. Romeo, Raja G. Achari, Shamin Ahmed, Jorge C. Demeireles, Tianquing Liu, Anthony P. Sileno
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Patent number: 6740660Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: GrantFiled: January 31, 2002Date of Patent: May 25, 2004Assignee: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20040033966Abstract: The invention pertains to a method for preparing dexchlorpheniramine (“dexchlor”) tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The dexchlorpheniramine free base may be obtained by reacting a commercially available dexchlorpheniramine salt such as dexchlorpheniramine maleate with a base such as aqueous sodium hydroxide. The resultant dexchlor tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: ApplicationFiled: August 14, 2003Publication date: February 19, 2004Applicant: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, Angelo R. Mellozzi, Vilas M. Chopdekar
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Patent number: 6677346Abstract: The present invention relates to a pharmaceutical formulation for intranasal administration comprising morphine or pharmaceutically acceptable salt thereof at a pH from about 3.0 to about 7.0. Such formulations provide enhanced absorption of morphine or pharmaceutically acceptable salts thereof. In one embodiment, the present invention provides a method for eliciting an analgesic or anesthetic response in a mammal which includes nasally administering a therapeutically effective amount of morphine or pharmaceutically acceptable salt thereof at a pH from about 3.0 to about 7.0.Type: GrantFiled: June 15, 2000Date of Patent: January 13, 2004Assignee: Nastech Pharmaceutical Company Inc.Inventors: Raja G. Achari, Charanjit R. Behl, Jorge C. deMeireles, Ramneik Dua, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20030114535Abstract: The invention pertains to a novel composition comprising dextrochlorpheniramine tannate and to a method for preparing such tannate by reacting dextrochlorpheniramine free base at a temperature of about 60 to about 150° C. with tannic acid preferably neat or as an aqueous slurry containing about 5 to about 30 wt. % water. The dextrochlorpheniramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: ApplicationFiled: July 27, 2002Publication date: June 19, 2003Applicant: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, Angelo R. Mellozzi, Vilas M. Chopdekar
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Publication number: 20020193397Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: January 31, 2002Publication date: December 19, 2002Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20020165249Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: January 31, 2002Publication date: November 7, 2002Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Publication number: 20020161017Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: ApplicationFiled: January 31, 2002Publication date: October 31, 2002Applicant: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Patent number: 6436950Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.Type: GrantFiled: June 16, 1999Date of Patent: August 20, 2002Assignee: Nastech Pharmaceutical Company, Inc.Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno