Patents by Inventor Raja G. Khalifah

Raja G. Khalifah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of Advanced Glycation End Products
    Publication number: 20210163450
    Abstract: The present disclosure provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
    Type: Application
    Filed: February 1, 2021
    Publication date: June 3, 2021
    Inventor: Raja G. Khalifah
  • Inhibitors of advanced glycation end products
    Patent number: 9428533
    Abstract: The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 30, 2016
    Assignee: Nephrogenex, Inc
    Inventors: Raja G. Khalifah, Roger E. Marti
  • Inhibitors of Advanced Glycation End Products
    Publication number: 20140187506
    Abstract: The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
    Type: Application
    Filed: February 20, 2014
    Publication date: July 3, 2014
    Applicant: NephroGenex, Inc.
    Inventors: Raja G. Khalifah, Roger E. Marti
  • Methods for the synthesis of pyridoxamine
    Patent number: 8431712
    Abstract: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: April 30, 2013
    Assignee: NephroGenex, Inc.
    Inventors: Raja G. Khalifah, Roland Keilitz, Christoph Koellner, Thorsten Degenhardt, Stephen Robert Brand
  • Inhibitors of Advanced Glycation End Products
    Publication number: 20110245269
    Abstract: The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
    Type: Application
    Filed: December 9, 2010
    Publication date: October 6, 2011
    Applicant: NephroGenex, Inc.
    Inventors: Raja G. Khalifah, Roger E. Marti
  • Methods for treating diabetic neuropathy
    Patent number: 7030146
    Abstract: A method for treating diabetic neuropathy is disclosed consisting of administering pyridoxamine or a salt thereof.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: April 18, 2006
    Assignees: University of South Carolina, Kansas University Medical Center
    Inventors: John W. Baynes, Suzanne R. Thorpe, Thorsten P. Degenhardt, Raja G. Khalifah, Billy G. Hudson, Nathan Alderson
  • Methods for inhibiting diabetic complications
    Patent number: 6740668
    Abstract: The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches methods to treat or prevent diabetes associated hyperlipidemia, cellular redox imbalances, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis, comprising administering the compounds of the invention to a mammal in need thereof.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: May 25, 2004
    Assignees: Kansas University Medical Center, University of South Carolina
    Inventors: John W. Baynes, Suzanne R. Thorpe, Thorsten P. Degenhardt, Raja G. Khalifah, Billy G. Hudson, Nathan Alderson
  • Methods for inhibiting diabetic complications
    Publication number: 20030181492
    Abstract: The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches methods to treat or prevent diabetes associated hyperlipidemia, cellular redox imbalances, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis, comprising administering the compounds of the invention to a mammal in need thereof.
    Type: Application
    Filed: January 30, 2003
    Publication date: September 25, 2003
    Applicant: University of South Carolina
    Inventors: John W. Baynes, Suzanne R. Thorpe, Thorsten P. Degenhardt, Raja G. Khalifah, Billy G. Hudson, Nathan Alderson