Abstract: The present disclosure provides methods, systems, and compositions of quantifying one or more analytes in a single sample volume without immobilization, separation, mass spectrometry, or melting curve analysis. Methods may comprise polymerase chain reaction and signal generation to quantify the analytes.

Abstract: This disclosure relates generally to a system and method for transactive energy (TE) market model. Existing TE models either consider market without a network simulation model or both the market model and the network simulation model are considered in a single formulation which makes the computation complex. The disclosed system considers both the power flow simulation of the network and the market model in a sequence. In other words, the disclosed system decouples the market model and network model to reduce the computational complexity at the same time without sacrificing on the technical feasibility of the solution.

Abstract: Anchor assemblies for endovascular introduction and implantation for tethering a replacement heart valve to a cardiac wall. An anchor delivery system introduces the assembly. The anchor may be either implanted with a tether connected thereto or implanted and then connected to a tether. If the latter, a tether assembly is mounted to the implanted anchor to connect the anchor to the valve. The anchors may be implanted into any cardiac wall including the interventricular septum or the epicardial space and the valve may replace the mitral or tricuspid valve.

Abstract: The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.

Abstract: An ophthalmic lens for treating myopia comprising: a base lens with a front surface, a back surface, and a first power profile selected to correct or substantially correct for a distance refractive error of the eye; one or more myopia control elements on at least one of the front and back surfaces of the lens; a first viewing region having a dimension selected based, at least in part, on a concentration of a pharmaceutical agent for use in conjunction with an ophthalmic lens, the first viewing region being configured to minimize, reduce and/or eliminate vision disturbances for distance vision; and a second viewing region comprising a power profile that is relatively more positive compared to the first viewing region; wherein at least one of the size of the second viewing region and the relatively more positive power of the second viewing region is selected based, at least in part, on the concentration of the pharmaceutical agent.

Abstract: The present disclosure is directed to lens, methods of making, designing lens and/or methods using lens in which performance may be improved by providing one or more steps in the central portion of the optical zone and one or more steps in the peripheral portion of the optic zone. In some embodiments, such lens may be useful for correcting refractive error of an eye and/or for controlling eye growth.

Abstract: A faceplate pluggable remote laser source and system incorporating such a laser source. The system may include an enclosure having a faceplate; a first optical connector, in the faceplate; a laser module; and a loopback fiber cable, connected between the laser module and the first optical connector. The faceplate may form an exterior boundary of the enclosure. The laser module may have a first end including an electrical interface, and a second end including an optical interface. The first end of the laser module may be engaged in a receptacle in the faceplate, and the second end of the laser module may extend outside the faceplate. The laser module may be configured to receive electrical power through the electrical interface, and to produce unmodulated light at the optical interface. The loopback fiber cable and the first optical connector may be configured to route the unmodulated light back into the enclosure.

Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).

Abstract: The present invention relates to an artificial intelligence based system and method for moderating interaction between interacting users. The attempt is to improve emotional intelligence of users so that a seasoned response and reaction is observed during interaction, even if situations of conflict arise. The disclosure, thus, provides for a mixed reality glass powered assistant that displays the moderated expressions of a customer to the service provider. For the same, the analytical engine upon determining the negative emotions of customer, transforms the image of customer and adds smile to his face, which is presented to the service provider via a mixed reality glass so that he responds back to the customer in a positive manner.

Abstract: A computer implemented system and method for generating a platform agnostic digital worker includes identifying a task to be performed by the digital worker. A specification for the digital worker is generated that comprises at least a predefined standard for configuration of input and output parameters and error handling. A digital worker created by an agent based on the specification is received to deploy the digital worker at an orchestration engine. The digital worker is sequenced into a repository of digital workers in a predefined manner of workflow, where the digital worker is configured to execute sequentially to perform a scheduled task.

Abstract: An atrial sealing skirt for transcatheter valves and an atrial sealing skirt with an integrated valve to reduce paravalvular regurgitation, with or without the presence of intracardiac leads. The atrial sealing skirt includes a top brim which is positioned to conform to the atrial floor at the deployment site.

Abstract: Described examples include an integrated circuit includes a protected node and a first transistor having a source coupled to the protected node, a gate and a drain coupled to a ground, wherein the first transistor is a MOSFET transistor. The integrated circuit also includes a second transistor having a first current handling terminal coupled to the protected node, a second current handling terminal coupled to the ground and a control terminal coupled to a reference potential, where the second transistor is configured to be off when a first voltage on the control terminal of the second transistor is less than a second voltage on the first current handling terminal of the second transistor.

Abstract: A system for diagnosing an improper reductant concentration includes: a selective catalytic reduction (SCR) catalyst unit, a doser configured to dose reductant into a chamber of the SCR catalyst unit, a reductant concentration sensor, and a controller. In some embodiments, the controller is configured to: direct the doser to dose the reductant into the chamber of the SCR catalyst unit, based on information received from the reductant concentration sensor, determine a reductant concentration level in the chamber of the SCR catalyst unit, compare a measured system-out NOx value to at least one benchmark value corresponding to the determined reductant concentration level, and determine a status of the reductant dosed by the doser based on the comparison of the measured system-out NOx value to the at least one benchmark value.

Abstract: A method and system for sharing product data in a collaborative environment is disclosed. In one embodiment, the method includes establishing a session for sharing product data between a source device and a target device. The method includes adaptively generating one or more payload files corresponding to the product data based on payload processing information. The payload processing information includes number of payload files waiting to be processed at the target device. Moreover, the method includes sending the one or more payload files to the target device over the product data sharing session such that the product data is reproduced at the target device using the payload files.

Abstract: A network function virtualization service includes an action implementation layer and an action decisions layer. On a flow of network traffic received at the service, the action implementation layer performs a packet processing action determined at the action decisions layer.

Abstract: Methods for regulating and continuously monitoring a chemical synthesis reaction using micro-objects and electro-magnetic radiation include introducing micro-objects to a reaction mixture, determining a plasmon resonance of the micro-object based on a characteristic of the micro-object, and applying electro-magnetic radiation that is wavelength-matched to the plasmon resonance of the micro-object.

Abstract: A heating, ventilation, and air conditioning (HVAC) fault prediction system for a building including a processing circuit including a processor and memory, the memory having instructions stored thereon that, when executed by the processor, cause the processing circuit to receive HVAC data relating to a plurality of HVAC components, the HVAC data indicating performance of the plurality of HVAC components, generate, based on the received HVAC data, a univariate prediction model and a multivariate prediction model, generate, using the received HVAC data, one or more predicted operational parameters for the plurality of HVAC components corresponding to a future time period, and execute at least one of the univariate prediction model or the multivariate prediction model on the one or more predicted operational parameters to predict a HVAC fault associated with at least one of the plurality of HVAC components to occur during the future time period.

Abstract: A facility for predicting patient outcomes on the basis of clinical trials is described. The facility obtains information describing one or more completed clinical trials, and extracts features from the obtained clinical trial information. The facility uses the extracted features to train both a time-series data model for predicting clinical outcomes and a non-time-series data model for predicting clinical outcomes. The facility applies these trained models to information describing a subject patient to predict a clinical outcome for the subject patient.

Abstract: This disclosure relates to a management system that coordinates an interoperable mesh of technologies and devices to manage a hospitality facility. This disclosure further relates to the identification of key issues associated with hospitality and facility management to address with management systems of this disclosure so as to provide a management system that is cost-effective and maximizes facility profitability.

Abstract: The present disclosure provides methods and compositions for multiplex quantitation. In some aspects, methods and compositions are provided for quantitation of nucleic acid targets from a biological sample. The disclosed methods may be useful in identifying or detecting genetic abnormalities from a subject.