Patents by Inventor Rajagopal Ramesh

Rajagopal Ramesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10293056
    Abstract: The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient in vivo nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific via cell specific targeting moieties. The present invention, thus provides non-viral, liposome compositions and methods of gene transfer particularly useful for targeting and treating hyperproliferative disease.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: May 21, 2019
    Assignees: Board of Regents, The University of Texas System, Introgen Research Institute, Inc.
    Inventors: Rajagopal Ramesh, Jack A. Roth, Tomoyuki Saeki, Deborah R. Wilson
  • Publication number: 20090004145
    Abstract: The present invention concerns the methods and compositions involving a therapeutic polypeptide, such as a tumor suppressor or a nucleic acid encoding such in combination with a proteasome inhibitor, for the treatment of cancer. In certain examples, a treatment for ovarian cancer is provided.
    Type: Application
    Filed: September 16, 2008
    Publication date: January 1, 2009
    Inventor: Rajagopal Ramesh
  • Publication number: 20070281041
    Abstract: The present invention concerns methods and compositions involving MDA-7 protein or an MDA-7-encoding nucleic acid and an EGFR inhibitor for the treatment of cancer. In certain embodiments, the invention specifically concerns a small molecule tyrosine kinase inhibitor, for example, erlotinib, as the EGFR inhibitor.
    Type: Application
    Filed: April 27, 2007
    Publication date: December 6, 2007
    Applicants: Introgen Therapeutics, Inc.
    Inventors: Rajagopal Ramesh, Sunil Chada
  • Publication number: 20070009484
    Abstract: The present invention concerns methods and compositions involving MDA-7 protein or an MDA-7-encoding nucleic acid in combination with either 1) a COX-2 selective inhibitor, such as celecoxib, 2) an Hsp90 inhibitor, such as geldanamycin, or a geldanamycin derivative or analog, 3) a vitamin E compound, for the treatment of cancer, 4) a TNF, such as TNF-alpha, 5) a VEGF inhibitor, or 6) an inhibitor of IL-10. In certain examples, a treatment for breast cancer is provided. In other examples a treatment for lung cancer is provided. Such examples involve, in some cases, an adenovirus vector that expresses MDA-7 protein.
    Type: Application
    Filed: February 8, 2006
    Publication date: January 11, 2007
    Inventors: Kelly Hunt, Young-Jin Suh, Stephen Swisher, Abujiang Pataer, Rajagopal Ramesh, Manish Shanker
  • Publication number: 20060134801
    Abstract: The present invention relates to compositions and methods involving MDA-7. More specifically, the present invention is directed to diagnostic, prognostic, and therapeutic treatment compositions and methods for treatment of cancer and other angiogenesis-related disorders (anti-angiogenesis therapy). The present invention is also directed to methods of purification of MDA-7.
    Type: Application
    Filed: March 2, 2004
    Publication date: June 22, 2006
    Inventors: Sunil Chada, John Mumm, Rajagopal Ramesh, Abner Mhashilkar, Raymond Meyn, Elizabeth Grimm
  • Publication number: 20050143336
    Abstract: Methods to prevent or reduce inflammation secondary to administration of a lipid-nucleic acid complex in a subject, that include administering to the subject a non-steroidal anti-inflammatory agent, a salicylate, an anti-rheumatic agent, an antihistamine, or an immunsuppressive agent with the lipid-nucleic acid complex are disclosed. Also disclosed are methods of screening for inhibitors of the inflammatory response associated with administration of a lipid-nucleic acid complex to a subject, including providing a candidate substance suspected of preventing or inhibiting the inflammation associated with administration of a lipid-nucleic acid complex to the subject. Also disclosed are compositions that include a lipid, a nucleic acid, and a non-steroidal anti-inflammatory agent, a salicylate, an anti-rheumatic agent, an antihistamine, or an immunosuppressive agent.
    Type: Application
    Filed: November 30, 2004
    Publication date: June 30, 2005
    Inventors: Rajagopal Ramesh, Began Gopalan, Jack Roth
  • Publication number: 20040009939
    Abstract: The present invention relates to compositions and methods for the enhancing or inducing an immune response against an immunogenic molecule by indirectly activating PKR. More specifically, immunotherapy is improved by co-administering a MDA-7 polypeptide with an immunogenic molecule against which an immune response is desired. Such immunotherapies include cancer vaccines, and compositions thereof are described.
    Type: Application
    Filed: March 3, 2003
    Publication date: January 15, 2004
    Applicants: Board of Regent, The University of Texas System, Introgen Therapeutics, Inc.
    Inventors: Sunil Chada, Abujiang Pataer, Abner Mhashilkar, Rajagopal Ramesh, Jack Roth, Steve Swisher
  • Publication number: 20020183271
    Abstract: The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed to methods for treating a subject with an angiogenesis-related disease. In one embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells, is administered to said patient with an angiogenesis-related disease. The present invention thus provides for treatment of angiogenesis-related disease by through expression of mda-7 and inhibition angiogenesis. Such diseases include cancer.
    Type: Application
    Filed: December 7, 2001
    Publication date: December 5, 2002
    Inventors: Sunil Chada, Elizabeth Grimm, Abner Mhashilkar, Rajagopal Ramesh