Abstract: Monitoring cardiopulmonary function of a patient based on cerebrospinal fluid (CSF) pressures involves fluidly communicating a first catheter with a first CSF access site of the patient; fluidly communicating a second catheter with a second CSF access site of the patient; providing, using a first pressure sensor in fluid communication with the first catheter, first pressure readings associated with the first CSF access site; providing, using a second pressure sensor in fluid communication with the second catheter, second pressure readings associated with the second CSF access site; and determining a cardiopulmonary function parameter associated with the patient based on first and second pressure signals derived from the first and second pressure readings. The first CSF access site may be associated with a brain ventricle of the patient and the second CSF access site may be associated with the patient's lumbar.

Abstract: A method of managing cancer in a patient’s cerebrospinal fluid (“CSF”) forms a fluid circuit by fluidly communicating a set of catheters (“a catheter”) with the patient’s brain ventricle and the patient’s lumbar and, while controlling the flow rate of the CSF through the CSF fluid circuit, filters cancer cells from the CSF through the fluid circuit. The method also determines both a variable indicative of cancer cell concentration in the CSF, and at some point, that the variable has attained or passed through a threshold value (e.g., greater than a maximum threshold value or below a minimum threshold value). The method stops controlling the CSF flow rate in response to the variable attaining and/or passing through the threshold value. The CSF flow rate therefore preferably returns to a natural CSF flow rate of the patient after stopping control of the CSF flow rate. A system preferably performs these acts.

Abstract: The invention concerns an injector device (100), comprising access means (110, 115) configured to selectively allow and prevent a cartridge (120) storing a pharmaceutical product (122) from being removed from the injector device (100), a self-test unit (130) configured to cause a self-test of at least one of an electronic component and an electronic assembly of the injector device (100), and a control unit (140) configured to control the access means (110, 115) to allow the cartridge (120) to be removed from the injector device (100) in case the self-test has failed.

Abstract: A needling device includes a plurality of needles forming a needle array, and a motor assembly for driving the needle array, where each of the plurality of needles includes a needle tip at one end, and tapers at a taper angle and along a taper length to a maximum needle diameter at the other end, and in use, a skin reference surface of the needling device is in contact with a subject's skin.

Abstract: A method, apparatus, system, and computer program code for digitally presenting a comparison of labor resource allocations between organizations. A computer system identifies employee data for a set of employees. The employee data includes job titles, and job descriptions. Using a set of machine learning models, the computer system extracts skills data from the job descriptions. Based on the skills data extracted from the job descriptions and using the set of machine learning models, the computer system maps the job titles to normalized titles within a job taxonomy that governs relationships between business functions, subfunctions, and the normalized titles. The computer system determines a resource allocation for an organization over each of the normalized titles. The computer system generates a granular comparison of the granular resource allocation to a set of benchmark allocations. The computer system digitally presents the granular comparison in a graphical user interface.

Abstract: The present disclosure generally relates to a system for flowing a fluid, e.g., CSF, from a body of a patient for sampling and analysis. In some embodiments, the system can include a diagnostic module having one or more conduits for flowing fluid therethrough. The flow of the fluid through the valves can be regulated using a control board that changes an orientation of valves disposed in the conduits between a dead-end orientation and a flow-through orientation to sample and/or analyze the fluid from the system. In some embodiments, the fluid can be recirculated into the system through one or more of the valves, with sampling and recirculating occurring substantially simultaneously.

Abstract: A method to regulate patient gene expression by controllably circulating antisense oligonucleotide material (ASO) through a closed fluid circuit formed between the patient's ventricle and lumbar regions. To that end, after coupling a fluid channel between those regions, such embodiments add ASO to the fluid channel (preferably after the channel is primed with CSF) and energize a pump to controllably flow the CSF and the ASO mixed with the CSF. CSF/ASO fluid flow may be managed to localize treatment (e.g., providing deep brain distribution) while minimizing toxicity potentially caused by the ASO to certain nerves (e.g., the peripheral nerve).

Abstract: A CSF management method and/or apparatus is used with a patient forms a CSF circuit having at least one pump and catheter. The CSF circuit is configured to control the flow of CSF in the patient's body. The method then flows, using the pump and the catheter, the patient's CSF at a given flow rate through the CSF circuit, and monitors, using a pressure sensor, the intracranial pressure in the craniospinal compartment of the patient when flowing CSF through the CSF circuit. For safety purposes, the method controls the given flow rate of the CSF in the CSF circuit as a function of the monitored intracranial pressure in the craniospinal compartment.

Abstract: A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Abstract: A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Abstract: A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Abstract: A system and method may provide for spatial and semantic auto-completion of an augmented or mixed reality environment. The system may detect physical objects in a physical environment based on analysis of image frames captured by an image sensor of a computing device. The system may detect spaces in the physical environment that are occupied by the detected physical objects, and may detect spaces that are unoccupied in the physical environment. Based on the identification of the detected physical objects, the system may gain a semantic understanding of the physical environment, and may determine suggested objects for placement in the physical environment based on the semantic understanding. The system may place virtual representations of the suggested objects in a mixed reality scene of the physical environment for user consideration.

Abstract: A medical device (100) comprises a container receiver unit (110) configured to receive and hold a container (120), wherein the container (120) accommodates a pharmaceutical product (125) and comprises a first communication tag (130) configured to store information regarding the pharmaceutical product (125), a reader unit (140) configured to wirelessly read the information from the first communication tag (130), and a control unit (150) configured to control the medical device (100) based on the information read from the first communication tag (130). The medical device (100) further comprises an opening or a transparent window (165) allowing to at least partially see from the outside the container (120) inserted into the container receiver unit (110), wherein the reader unit (140) comprises a first antenna unit (142, 144), and the container (120) inserted into the container receiver unit (110) is located between (i) the opening or the transparent window (165) and (ii) the first antenna unit (142, 144).

Abstract: An orthopedic surgical device and method of using thereof is provided. The orthopedic surgical device includes a sensor portion including a conformable pad sized for positioning within a knee joint of a patient. The pad includes a femoral side and a tibial side and a sensor array disposed between the femoral side and the tibial side configured to generate a signal indicative of the force within the knee joint. The tibial side includes an adhesive coating. The orthopedic surgical device also includes a display portion including a display and a controller. The controller is configured to receive the signal from the sensor array and to control the display to provide a visual indication of the force within the knee joint.

Abstract: A system and method may provide for spatial and semantic auto-completion of an augmented or mixed reality environment. The system may detect physical objects in a physical environment based on analysis of image frames captured by an image sensor of a computing device. The system may detect spaces in the physical environment that are occupied by the detected physical objects, and may detect spaces that are unoccupied in the physical environment. Based on the identification of the detected physical objects, the system may gain a semantic understanding of the physical environment, and may determine suggested objects for placement in the physical environment based on the semantic understanding. The system may place virtual representations of the suggested objects in a mixed reality scene of the physical environment for user consideration.

Abstract: An electrosurgical device having a handpiece including a controller and an electrode assembly extending from the handpiece is disclosed. The electrode assembly includes a monopolar blade and a monopolar electrode. The monopolar blade includes a conductive element partially coated with an insulator and electrically coupled to the controller to selectively deliver a monopolar radiofrequency (RF) cutting signal. The monopolar electrode is spaced apart and electrically isolated from the monopolar blade. The monopolar electrode includes an exposed major conductive surface electrically coupled to the controller to selectively deliver a monopolar RF hemostatic sealing signal with a dispersed fluid.

Abstract: The invention concerns an injector device (100), comprising access means (110, 115) configured to selectively allow and prevent a cartridge (120) storing a pharmaceutical product (122) from being removed from the injector device (100), a self-test unit (130) configured to cause a self-test of at least one of an electronic component and an electronic assembly of the injector device (100), and a control unit (140) configured to control the access means (110, 115) to allow the cartridge (120) to be removed from the injector device (100) in case the self-test has failed.

Abstract: An orthopedic surgical device and method of using thereof is provided. The orthopedic surgical device includes a sensor portion including a conformable pad sized for positioning within a knee joint of a patient. The pad includes a femoral side and a tibial side and a sensor array disposed between the femoral side and the tibial side configured to generate a signal indicative of the force within the knee joint. The tibial side includes an adhesive coating. The orthopedic surgical device also includes a display portion including a display and a controller. The controller is configured to receive the signal from the sensor array and to control the display to provide a visual indication of the force within the knee joint.

Abstract: A driving mechanism (100) for an injector device comprises a coil spring (10) having a proximal end (12) and a distal end (14), a spring guide (20) adapted to guide a movement of the coil spring (10), and an actuator (50, 52, 54, 56, 58, 60) adapted to cause a force on the proximal end (12) of the coil spring (10), wherein the spring guide (20) comprises a curved part (22) having a curved shape. An injector device comprises a driving mechanism (100) and a needle ejection mechanism comprising a hollow skin needle, wherein the driving mechanism (100) is adapted to cause a dispensing of a drug from a cartridge (70) through the hollow skin needle and an ejection of the hollow skin needle from the injector device.

Abstract: A medical device (100) comprises a container receiver unit (110) configured to receive and hold a container (120), wherein the container (120) accommodates a pharmaceutical product (125) and comprises a first communication tag (130) configured to store information regarding the pharmaceutical product (125), a reader unit (140) configured to wirelessly read the information from the first communication tag (130), and a control unit (150) configured to control the medical device (100) based on the information read from the first communication tag (130). The medical device (100) further comprises an opening or a transparent window (165) allowing to at least partially see from the outside the container (120) inserted into the container receiver unit (110), wherein the reader unit (140) comprises a first antenna unit (142, 144), and the container (120) inserted into the container receiver unit (110) is located between (i) the opening or the transparent window (165) and (ii) the first antenna unit (142, 144).