Patents by Inventor Rajanish Giri

Rajanish Giri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20230212258
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti -gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 6, 2023
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20220332790
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti-gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: June 23, 2022
    Publication date: October 20, 2022
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 11421014
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 23, 2022
    Assignee: McMaster University
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Mwawasi
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 11008376
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: May 18, 2021
    Assignee: McMaster University
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 11001621
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: May 11, 2021
    Assignee: McMaster University
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20210130435
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: January 12, 2021
    Publication date: May 6, 2021
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20200270330
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 27, 2020
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20200071377
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: August 21, 2019
    Publication date: March 5, 2020
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 10435453
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: October 8, 2019
    Assignee: MCMASTER UNIVERSITY
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20160368964
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 22, 2016
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi