Patents by Inventor Rajaram Sankara Subramanian

Rajaram Sankara Subramanian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride
    Patent number: 7094928
    Abstract: This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5-dimethoxyphenyl)-2-bromoethanone by reacting the same with hexamine in the presence of novel solvent system comprising Tetrahydrofuran and water. The resulting aminoethanone is acylated with haloacetylchloride and sodium acetate in acetone-water solvent system. This product is reduced selectively first with sodium borohydride and subsequently with stannous chloride. This product is converted in situ to the corresponding hydrochloride salt immediately after reduction on its own.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: August 22, 2006
    Assignee: Sanmar Specialty Chemicals Ltd.
    Inventors: Rajaram Sankara Subramanian, Venkatanathan Satagopan, Rajagopalan Srinivasan
  • Process for the synthesis of (+) 2-amino-n-2, (2,5-dimethoxy phenyl)-2-hydroxyethyl acetamide monohydrochloride
    Publication number: 20040198836
    Abstract: This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5-dimethoxyphenyl)-2-bromoethanone by reacting the same with hexamine in the presence of novel solvent system comprising Tetrahydrofuran and water. The resulting aminoethanone is acylated with haloacetylchloride and sodium acetate in acetone-water solvent system. This product is reduced selectively first with sodium borohydride and subsequently with stannous chloride. This product is converted in situ to the corresponding hydrochloride salt immediately after reduction on its own.
    Type: Application
    Filed: February 6, 2004
    Publication date: October 7, 2004
    Inventors: Rajaram Sankara Subramanian, Venkatanathan Satogopan, Rajagopalam Srinivasan