Patents by Inventor Rajaram Sriram

Rajaram Sriram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Submicron suspensions with polymorph control
    Publication number: 20060134150
    Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically active compound, the solubility of which is greater in a water miscible first organic solvent than in a second solvent which is aqueous, The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically active compound in the water miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically active compound; and (iii) seeding the first solution or the second solvent or the presuspension.
    Type: Application
    Filed: February 27, 2006
    Publication date: June 22, 2006
    Inventors: Jane Werling, James Kipp, Rajaram Sriram, Mark Doty
  • Method for preparing submicron suspensions with polymorph control
    Patent number: 6977085
    Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: December 20, 2005
    Assignee: Baxter International Inc.
    Inventors: Jane Werling, James E. Kipp, Rajaram Sriram, Mark J. Doty
  • Preparation of submicron sized particles with polymorph control
    Publication number: 20030096013
    Abstract: The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing a pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7 &mgr;m.
    Type: Application
    Filed: September 17, 2002
    Publication date: May 22, 2003
    Inventors: Jane Werling, James E. Kipp, Rajaram Sriram, Mark J. Doty
  • Method for preparing submicron suspensions with polymorph control
    Publication number: 20030044433
    Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the presuspension.
    Type: Application
    Filed: October 19, 2001
    Publication date: March 6, 2003
    Inventors: Jane Werling, James E. Kipp, Rajaram Sriram, Mark J. Doty