Patents by Inventor Rajarathnam E. Reddy

Rajarathnam E. Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20200325506
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: November 4, 2019
    Publication date: October 15, 2020
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • ENZYMATIC PROCESS FOR THE PREPARATION OF (1S,2R)-2-(DIFLUOROMETHYL)-1-(PROPOXYCARBONYL)CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20200024621
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 23, 2020
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Stefan Mix, Gareth J. Brown
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10465216
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: November 5, 2019
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
    Patent number: 10316338
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Abb Vie Inc.
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Gareth J. Brown, Stefan Mix
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20190048372
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • VARIANT POLYPEPTIDES CAPABLE OF AMINATING ALIPHATIC ALPHA KETO ACIDS
    Publication number: 20190048326
    Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
    Type: Application
    Filed: October 26, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Abrahamson, Rajarathnam E. Reddy, William T. Riordan, Sanjay R. Chemburkar
  • Variant polypeptides capable of aminating aliphatic alpha keto acids
    Patent number: 10113152
    Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: October 30, 2018
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Rajarathnam E. Reddy, William T. Riordan, Sanjay R. Chemburkar
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10059969
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 28, 2018
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Process for the synthesis of (2S,3AR,7AS)-octahydro-1H-indole carboxylic acid as an intermediate for trandolapril
    Patent number: 8288565
    Abstract: A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: October 16, 2012
    Assignee: Abbott Laboratories
    Inventors: Sanjay R. Chemburkar, Rajarathnam E. Reddy, Douglas M. Reamer, John T. Pavlina, Stephen S. Ulrey, Brian J. Kotecki
  • PROCESS FOR THE PREPARATION OF SCYLLO-INOSITOL
    Publication number: 20110201060
    Abstract: This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting myo-Inositol to scyllo-Inositol using a bioconversion process.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 18, 2011
    Applicant: Abbott Laboratories
    Inventors: Rajarathnam E. Reddy, Sanjay R. Chemburkar, Douglas R. Spaulding, Yi Pan, Lei Cao, Jose A. Restituyo, Richard Lorenzini, Michael DeMarco
  • PROCESS FOR THE SYNTHESIS OF (2S,3AR,7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL
    Publication number: 20110065930
    Abstract: A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.
    Type: Application
    Filed: July 16, 2010
    Publication date: March 17, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Sanjay R. Chemburkar, Rajarathnam E. Reddy, Douglas M. Reamer, John T. Pavlina, Stephen S. Ulrey, Brian J. Kotecki
  • Determination of concentration of FK778 by competitive immunoassay
    Patent number: 7256008
    Abstract: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: August 14, 2007
    Assignee: Abbott Laboratories
    Inventors: Thomas G. Spring, Elaine M. Brate, Shelley Holets-McCormack, Rajarathnam E. Reddy, Donald D. Johnson, Yon-Yih Chen, You Pan