Abstract: Synbiotic compositions including both a prebiotic component and a probiotic component are provided. The prebiotic component includes at least one punicalagin, and the probiotic component includes a rationally defined and assembled consortium of microbial strains. Delivery capsules for oral administration of the synbiotic compositions and methods of using the synbiotic compositions to treat disease are also provided.

Abstract: Synbiotic compositions including both a prebiotic component and a probiotic component are provided. The prebiotic component includes at least one punicalagin, and the probiotic component includes a rationally defined and assembled consortium of microbial strains. Delivery capsules for oral administration of the synbiotic compositions and methods of using the synbiotic compositions to treat disease are also provided.

Abstract: The present invention comprises compositions, systems, and methods of improving the skin and the skin microbiome using bacterial strains and their derivatives, and prebiotics. A useful composition of the invention comprises at least one of (a) a prebiotic that selectively promotes the growth of at least one desirable strain of Cutibacterium acnes (C. acnes); (b) a probiotic comprising at least one desirable strain of C. acnes; and (c) a post-biotic comprising at least one molecule produced by C. acnes.

Abstract: The present invention comprises compositions, systems, and methods of improving the skin and the skin microbiome using bacterial strains and their derivatives, and prebiotics. A useful composition of the invention comprises at least one of (a) a prebiotic that selectively promotes the growth of at least one desirable strain of Cutibacterium acnes (C. acnes); (b) a probiotic comprising at least one desirable strain of C. acnes; and (c) a post-biotic comprising at least one molecule produced by C. acnes.

Abstract: A pump assembly cap includes an accumulator reservoir configured for fluid communication with a container through a one-way inlet valve. An actuator including a dispensing passage having a dispensing orifice. A delivery path extended from the one-way inlet valve, through the accumulator reservoir, the one-way outlet valve, and to the dispensing orifice. The delivery path includes a sealed configuration and an opened configuration. In the sealed configuration, the actuator is in a ready position and the accumulator reservoir includes a first volume, the one-way outlet valve hermetically seals the accumulator reservoir, and the one-way inlet valve is closed. In the opened configuration, the actuator is moved to a dispensing position and the accumulator reservoir includes a second volume less than the first volume, the hermetic seal of the one-way outlet is open, and the one-way inlet valve is closed.

Abstract: A pump assembly cap includes an accumulator reservoir configured for fluid communication with a container through a one-way inlet valve. An actuator including a dispensing passage having a dispensing orifice. A delivery path extended from the one-way inlet valve, through the accumulator reservoir, the one-way outlet valve, and to the dispensing orifice. The delivery path includes a sealed configuration and an opened configuration. In the sealed configuration, the actuator is in a ready position and the accumulator reservoir includes a first volume, the one-way outlet valve hermetically seals the accumulator reservoir, and the one-way inlet valve is closed. In the opened configuration, the actuator is moved to a dispensing position and the accumulator reservoir includes a second volume less than the first volume, the hermetic seal of the one-way outlet is open, and the one-way inlet valve is closed.