Abstract: Provided are Raman systems and methods for detection of cancerous tissues in tumor margins in real time during surgical procedures. The systems include a laser excitation source, a probe, a spectrometer and a camera specifically designed for use of Raman spectroscopy in real time during surgery. The inventive methods pertain to quality assessment of Raman data, comparison of obtained Raman data against known biomarkers and classification of tissue as cancerous or non-cancerous on the basis of corresponding Raman data. The systems and methods allow for previously unavailable detection and classification of tissue with Raman spectroscopy in real time surgical applications, including the identification of cancer sub-types.

Abstract: Provided are Raman systems and methods for detection of cancerous tissues in tumor margins in real time during surgical procedures. The systems include a laser excitation source, a probe, a spectrometer and a camera specifically designed for use of Raman spectroscopy in real time during surgery. The inventive methods pertain to quality assessment of Raman data, comparison of obtained Raman data against known biomarkers and classification of tissue as cancerous or non-cancerous on the basis of corresponding Raman data. The systems and methods allow for previously unavailable detection and classification of tissue with Raman spectroscopy in real time surgical applications, including the identification of cancer sub-types.

Abstract: A system for automated collection of Raman spectra from ex-vivo tissue samples is provided. The system may comprise a cartesian robot that moves a detachable Raman probe to points on the ex-vivo tissue sample that have been predetermined through a 3D image of the sample. Accordingly, methods of rapid acquisition of multiple Raman spectra from a heterogeneous tissue sample are provided. The inventive methods consider variable contours of the sample to provide Raman spectra from multiple points while generating optimal coverage of the sample. The inventive methods include cleaning the Raman probe between acquisitions of Raman spectra from the multiple points.

Abstract: A system for automated collection of Raman spectra from ex-vivo tissue samples is provided. The system may comprise a cartesian robot that moves a detachable Raman probe to points on the ex-vivo tissue sample that have been predetermined through a 3D image of the sample. Accordingly, methods of rapid acquisition of multiple Raman spectra from a heterogeneous tissue sample are provided. The inventive methods consider variable contours of the sample to provide Raman spectra from multiple points while generating optimal coverage of the sample. The inventive methods include cleaning the Raman probe between acquisitions of Raman spectra from the multiple points.

Abstract: Provided are Raman systems and methods for detection of cancerous tissues in tumor margins in real time during surgical procedures. The systems include a laser excitation source, a probe, a spectrometer and a camera specifically designed for use of Raman spectroscopy in real time during surgery. The inventive methods pertain to quality assessment of Raman data, comparison of obtained Raman data against known biomarkers and classification of tissue as cancerous or non-cancerous on the basis of corresponding Raman data. The systems and methods allow for previously unavailable detection and classification of tissue with Raman spectroscopy in real time surgical applications, including the identification of cancer sub-types.

Abstract: A method of operation of a navigation system includes: determining a start guidance area excluding a current location; determining an end guidance area excluding a destination; and generating a navigation guidance with a control unit for traversing from the start guidance area to the end guidance area to reach the destination.

Abstract: Embodiments are directed to systems, methods, and devices for providing help to a user through an output modality. Embodiments include an analysis logic implemented at least partially in hardware to receive an indication to provide help or other information to the user; identify an availability of one or more output modalities for providing the help; and determine an output modality for providing the help based on the availability of the one or more output modalities. Embodiments also include a dialog system implemented at least partially in hardware to process the request for help; and provide a dialog message in response to the request for help, the dialog message provided on the determined output modality. Some embodiments also include a sensor input for receiving sensory information, wherein the analysis logic identifies the output modality based, at least in part, on the sensory information.

Abstract: A method of operation of a navigation system includes: determining a travel context based on a route condition for providing a navigation guidance; generating a state node having a state content with a control unit based on the travel context; and generating a guidance process based on the state node for presenting a prompt on a device.

Abstract: A method of operation of a content delivery system includes: receiving a command phrase based on determining an utterance type according to a travel context; determining a trigger match with a control unit based on the command phrase matching a trigger phrase; and stopping a prompt according to a prompt type based on the trigger match for controlling the prompt presented by a device.

Abstract: A method of operation of a computing system includes: receiving a interrupt request for an interrupt task request; determining a request intent, with a control unit, from the interrupt request; generating a system notification for the interrupt task request based on the request intent; and determining a presentation order of the system notification relative to an existing system notification based on a notification priority associated with the interrupt task request.

Abstract: A method and an apparatus to disambiguate requests are presented. In one embodiment, the method includes receiving a request for information from a user. Then data is retrieved from a back-end database in response to the request. Based on a predetermined configuration of a disambiguation system and the data retrieved, the ambiguity within the request is dynamically resolved.

Abstract: A method of operation of a navigation system includes: determining a start guidance area excluding a current location; determining an end guidance area excluding a destination; and generating a navigation guidance with a control unit for traversing from the start guidance area to the end guidance area to reach the destination.

Abstract: A method of operation of a navigation system includes: providing a history list including a request having a tag; assigning a probability to the request based on the tag to create a speaker dependent model; providing a returned result generated from the speaker dependent model; and updating the request and the tag of the history list based on a user's confirmation of the returned result for displaying on a device.

Abstract: A method of operation of a computing system includes: receiving a interrupt request for an interrupt task request; determining a request intent, with a control unit, from the interrupt request; generating a system notification for the interrupt task request based on the request intent; and determining a presentation order of the system notification relative to an existing system notification based on a notification priority associated with the interrupt task request.

Abstract: A method of operation of a navigation system includes: determining a travel context based on a route condition for providing a navigation guidance; generating a state node having a state content with a control unit based on the travel context; and generating a guidance process based on the state node for presenting a prompt on a device.

Abstract: A method of operation of a content delivery system includes: receiving a command phrase based on determining an utterance type according to a travel context; determining a trigger match with a control unit based on the command phrase matching a trigger phrase; and stopping a prompt according to a prompt type based on the trigger match for controlling the prompt presented by a device.

Abstract: A method and an apparatus to disambiguate requests are presented. In one embodiment, the method includes receiving a request for information from a user. Then data is retrieved from a back-end database in response to the request. Based on a predetermined configuration of a disambiguation system and the data retrieved, the ambiguity within the request is dynamically resolved.

Abstract: A method and an apparatus to disambiguate requests are presented. In one embodiment, the method includes receiving a request for information from a user. Then data is retrieved from a back-end database in response to the request. Based on a predetermined configuration of a disambiguation system and the data retrieved, the ambiguity within the request is dynamically resolved.

Abstract: A pulmonary artery pressure estimator attaches a plurality of acoustic sensors to a patient so as to measure a second heart sound. The sensors are arranged so that an A2 component of the second heart sound is maximized from at least one of the sensors and a P2 component is maximized from at least another one of the sensors. Electrodes are also attached to the patient so as to measure a cardiac interval. A splitting interval is derived from the A2 and P2 components, which is normalized by the cardiac interval. The normalized splitting interval provides an estimation of the pulmonary artery pressure (PAP).

Abstract: A method and apparatus for estimating a location of pulmonary and aortic components of second heart sounds of a patient over an interval. The method comprises the steps of producing an electronic representation of heart sounds of the patient over the interval, identifying at least one second heart sound in the interval using the electronic representation, for each identified second heart sound generating an estimated value for a location of the aortic component and the pulmonary component. There is also included a method for using the estimated location of the aortic component and the pulmonary component for estimation of the blood pressure in the pulmonary artery of a patient.